Exploiting the pathophysiology of the gut towards innovative oral peptide delivery strategies

Project Information

NanoGut

Grant agreement ID: 850997

DOI

10.3030/850997

Project closed

EC signature date 25 October 2019

Start date 1 January 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 488 937,50

EU contribution

€ 1 488 937,50

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion

Author(s): Yining Xu, Cécilia Bohns Michalowski, Jackie Koehler, Tamana Darwish, Nunzio Guccio, Constanza Alcaino, Inês Domingues, Wunan Zhang, Valentina Marotti, Matthias Van Hul, Paola Paone, Melitini Koutsoviti, Ben J. Boyd, Daniel J. Drucker, Patrice D. Cani, Frank Reimann, Fiona M. Gribble, Ana Beloqui
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.adq9909

Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease

Author(s): Inês Domingues, Hafsa Yagoubi, Wunan Zhang, Valentina Marotti, Espoir K. Kambale, Katlijn Vints, Malgorzata Alicja Sliwinska, Isabelle A. Leclercq, Ana Beloqui
Published in: Drug Delivery and Translational Research, Issue 14, 2024, Page(s) 2917-2929, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01576-z

Exploiting the biological effect exerted by lipid nanocapsules in non-alcoholic fatty liver disease

Author(s): Inês Domingues, Cecilia Bohns Michalowski, Valentina Marotti, Wunan Zhang, Matthias Van Hul, Patrice D. Cani, Isabelle A. Leclercq, Ana Beloqui
Published in: Journal of Controlled Release, Issue 356, 2025, Page(s) 542-553, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.03.012

Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment

Author(s): Yining Xu, Herlinde De Keersmaecker, Kevin Braeckmans, Stefaan De Smedt, Patrice D. Cani, Véronique Préat, Ana Beloqui
Published in: Biomaterials, 2020, Page(s) 120209, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120209

A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment

Author(s): Valentina Marotti, Yining Xu, Cécilia Bohns Michalowski, Wunan Zhang, Inês Domingues, Hafsa Ameraoui, Tom G. Moreels, Pieter Baatsen, Matthias Van Hul, Giulio G. Muccioli, Patrice D. Cani, Mireille
Published in: Bioactive Materials, 2024, ISSN 2452-199X
Publisher: KeAi Communications Co
DOI: 10.1016/j.bioactmat.2023.09.014

Gut hormone stimulation as a therapeutic approach in oral peptide delivery

Author(s): Ana Beloqui
Published in: Journal of Controlled Release, Issue 373, 2024, Page(s) 31-37, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2024.07.007

Intellectual Property Rights

Patent (2)

LIPID NANOCAPSULES CHARGED WITH INCRETIN MIMETICS

Application/Publication number: 20 729684
Date: 2020-05-27
Applicant(s): UNIVERSITE CATHOLIQUE DE LOUVAIN

LIPID NANOCAPSULES CHARGED WITH INCRETIN MIMETICS

Application/Publication number: 20 20064766
Date: 2020-05-27
Applicant(s): UNIVERSITE CATHOLIQUE DE LOUVAIN