Bioactive nanocarriers as an oral peptide delivery strategy
Development of a novel oral drug delivery system for therapeutic peptides is a major challenge in the treatment of chronic diseases such as type 2 diabetes. This EU-funded project will work on the application of nanocarriers for peptide delivery, which protects its cargo against chemical and enzymatic degradation while enabling controlled release, targeting and increased bio-availability. Project strategy stems from an earlier observation that lipid-based nanocarriers themselves trigger endogenous bio-active peptide secretion in vivo after oral administration to mice. Current research will aim to develop a dual-action delivery system that combines the biological effect of the nanocarriers and that of the encapsulated drug to enable complex and very efficient treatments for gastrointestinal disorders.
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