CORDIS - EU research results
CORDIS

Supramolecular Engineering of biologically iNSpired peptide nanostructurEs

Project description

Smart nanostructures inspired by proteins may improve cell function

Proteins are the workhorses of cells. These amino acid chains twist themselves into complex 3D structures that change dynamically to expose or hide binding sites or otherwise alter their functionality depending on cellular needs. They respond to numerous stimuli and are perhaps the ultimate smart material. Endowing synthetic, bioactive, self-assembled nanoarchitectures with this dynamic ability to reconfigure themselves will allow for enhanced control and tuning of their properties and thus be of value to various applications. The EU-funded SENSE project has set out to do just that, engineering stimuli-responsive self-assembled nanostructures, starting from building blocks based on small chains of amino acids. The goal is to integrate them into living cells to control cellular behaviours, using them as both bioactive scaffolds and smart delivery vehicles for a variety of agents.

Objective

To date, the main efforts for the design of bioactive self-assembled 1D nanostructures have been focused on the use of static assemblies. The development of synthetic systems with inherently stimuli-responsive behavior will open new possibilities for the creation of artificial architectures that mimic the natural protein nanostructures found in eukaryotic cells, which are dynamic, and capable of rapid growth or disassembly to tune their properties, and thus adapt to the cell needs.
SENSE aims to:
1) Define robust peptide-based building blocks, and implement stimuli-responsive interactions between them to engineer complex self-assembled responsive nanostructures.
2) Modify these dynamic platforms to achieve precise nanoscale control over the presentation of bioactive molecules in the final multivalent nanostructures.
3) Apply these responsive and multivalent nanostructures as smart delivery vehicles and improved bioactive scaffolds.
4) Integrate them into living cells as artificial adaptor nanostructures that can present multiple signaling elements for controlling cell behavior.
Taken together, the objectives of SENSE will define a new multidisciplinary approach combining organic, peptide, supramolecular and dynamic covalent chemistries, and nanotechnology for the development of adaptive materials that rely on dynamic interactions, and are therefore ideally suited to interfacing with living organisms.
During my career I have acquired the singular background that combines chemistry, chemical biology, and nanotechnology required to achieve the objectives of SENSE. Particularly relevant to this project is my experience in peptide synthesis and their modification, as well as in the preparation of supramolecular peptide-based materials and the study of their properties in living cells.

Host institution

UNIVERSIDADE DA CORUNA
Net EU contribution
€ 1 494 375,00
Address
CALLE DE LA MAESTRANZA 9
15001 La Coruna
Spain

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Region
Noroeste Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 1 494 375,00

Beneficiaries (1)