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Understanding the impact of nanoplastics on the development of neurological disorders

Project description

Investigating the role of nanoplastics in neurological disorders

Plastic nanoparticles, detected in a variety of ecosystems, can translocate from the gut to the lymph and circulatory systems, and cross the blood-brain barrier in mammals. However, the long-term effects of nanoplastics in the brain are unknown. Microglia are neuroimmune cells which sense and respond to environmental changes. They are essential for neuronal homeostasis and may be activated by nanoplastics reaching the brain. The EU-funded NanoGlia project will use rodent animal models to investigate behavioural, cellular and molecular changes in the brain following ingestion of nanoplastics. The project will study nanoplastics-induced developmental reprogramming events in fetal microglia that may influence brain organogenesis and function. NanoGlia seeks to understand how nanoplastics cause microglial activation during embryogenesis and postnatal stages, and whether this immune activation might lead to permanent changes in brain development and function.

Field of science

  • /medical and health sciences/basic medicine/immunology

Call for proposal

ERC-2019-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Address
Regina Pacis Weg 3
53113 Bonn
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 497 193

Beneficiaries (1)

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 1 497 193
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments