Project description DEENESFRITPL Investigating the role of nanoplastics in neurological disorders Plastic nanoparticles, detected in a variety of ecosystems, can translocate from the gut to the lymph and circulatory systems, and cross the blood-brain barrier in mammals. However, the long-term effects of nanoplastics in the brain are unknown. Microglia are neuroimmune cells which sense and respond to environmental changes. They are essential for neuronal homeostasis and may be activated by nanoplastics reaching the brain. The EU-funded NanoGlia project will use rodent animal models to investigate behavioural, cellular and molecular changes in the brain following ingestion of nanoplastics. The project will study nanoplastics-induced developmental reprogramming events in fetal microglia that may influence brain organogenesis and function. NanoGlia seeks to understand how nanoplastics cause microglial activation during embryogenesis and postnatal stages, and whether this immune activation might lead to permanent changes in brain development and function. Show the project objective Hide the project objective Objective An omnipresent but understudied environmental risk for our immune system is pollution by nano-sized plastics. Plastic particles have been detected in a wide variety of ecosystems and are speculated to enter and spread in the food web all the way to humans. Ingested nanoplastics can translocate from the gut to the lymph and circulatory systems and have the capacity to cross the blood-brain barrier in mammals. It has been recently shown that nanoplastics cause behavioural disorders in fish, and thus may also represent a risk for human health, in particular for brain function. However, the long-term bioavailability and toxicity of nanoplastics in the brain are unknown. Microglia as the main neuroimmune cells have not only a defence function required during inflammatory conditions, but constantly sense and response to environmental changes as part of their housekeeping functions that are essential for neuronal homeostasis. This places microglia at the interface between normal and abnormal brain development and function. In line with this, we have recently discovered that chronic microglial activation causes neurodegeneration. As highly phagocytic cells, microglia internalize nanoplastics reaching the brain. This process might in turn lead to their acute or chronic activation, thereby triggering neurological disorders. In NanoGlia, we will use rodent animal models to investigate behavioural as well as cellular and molecular changes in the brain that occur upon ingestion of nanoplastics. We will further determine nanoplastics-induced developmental reprogramming events in fetal microglia that may influence brain organogenesis and function. Understanding how nanoplastics triggers microglial activation during embryogenesis and postnatal stages and whether this immune activation leads to permanent changes in brain development and function will reveal ground-breaking mechanistic insights into the environmentally triggered pathogenesis of neurological disorders. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesdevelopmental biologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicineneurologymedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2019-STG - ERC Starting Grant Call for proposal ERC-2019-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Coordinator RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Net EU contribution € 1 497 193,00 Address Regina pacis weg 3 53113 Bonn Germany See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Germany Net EU contribution € 1 497 193,00 Address Regina pacis weg 3 53113 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
