Design Principles of Branching Morphogenesis

Información del proyecto

Demos

Identificador del acuerdo de subvención: 851288

DOI

10.3030/851288

Proyecto cerrado

Fecha de la firma de la CE 19 Noviembre 2019

Fecha de inicio 1 Julio 2020

Fecha de finalización 30 Junio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 452 604,00

Aportación de la UE

€ 1 452 604,00

Coordinado por

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (22)

Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming

Autores: Diana Pinheiro; Roland Kardos; Edouard Hannezo; Carl-Philipp Heisenberg
Publicado en: Nature Physics, 2022, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1038/s41567-022-01787-6

Mechanochemical bistability of intestinal organoids enables robust morphogenesis

Autores: Shi-Lei Xue, Qiutan Yang, Prisca Liberali, Edouard Hannezo
Publicado en: Nature Physics, Edición 21, 2025, Página(s) 608-617, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1038/s41567-025-02792-1

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

Autores: Simona Hankeova; Jakub Salplachta; Tomas Zikmund; Michaela Kavkova; Noémi Van Hul; Adam Brinek; Veronika Smekalova; Jakub Laznovsky; Feven Dawit; Josef Jaros; Vítězslav Bryja; Urban Lendahl; Ewa Ellis; Antal Nemeth; Björn Fischler; Edouard Hannezo; Jozef Kaiser; Emma Rachel Andersson
Publicado en: eLife, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.60916

Retrograde movements determine effective stem cell numbers in the intestine

Autores: Maria Azkanaz, Bernat Corominas-Murtra, Saskia I. J. Ellenbroek, Lotte Bruens, Anna T. Webb, Dimitrios Laskaris, Koen C. Oost, Simona J. A. Lafirenze, Karl Annusver, Hendrik A. Messal, Sharif Iqbal, Dustin J. Flanagan, David J. Huels, Felipe Rojas-Rodríguez, Miguel Vizoso, Maria Kasper, Owen J. Sansom, Hugo J. Snippert, Prisca Liberali, Benjamin D. Simons, Pekka Katajisto, Edouard Hannezo, Jacco
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04962-0

A self-generated Toddler gradient guides mesodermal cell migration

Autores: Jessica Stock; Tomas Kazmar; Friederike Schlumm; Edouard Hannezo; Andrea Pauli
Publicado en: Science Advances, 2022, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.add2488

Mechanical control of cell fate decisions in the skin epidermis

Autores: Preeti Sahu, Sara Monteiro-Ferreira, Sara Canato, Raquel Maia Soares, Adriana Sánchez-Danés, Edouard Hannezo
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-62882-9

Theory of branching morphogenesis by local interactions and global guidance

Autores: Ucar, Mehmet C, Kamenev Dmitrii, Sunadome Kazunori, Fachet, Dominik, Lallemend Francois, Adameyko Igor, Hadjab, Saida, Hannezo, Edouard
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27135-5

Optimality as a framework for understanding developmental robustness

Autores: Prachiti Moghe, Edouard Hannezo, Takashi Hiiragi
Publicado en: Trends in Cell Biology, Edición 36, 2026, Página(s) 246-256, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2025.08.009

Modelling the dynamics of mammalian gut homeostasis

Autores: Bernat Corominas-Murtra, Edouard Hannezo
Publicado en: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2022.11.005

Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics

Autores: Iris. A. Unterweger, Julie Klepstad, Edouard Hannezo, Pia R. Lundegaard, Ala Trusina, Elke A. Ober
Publicado en: PLOS Biology, Edición 21, 2024, Página(s) e3002315, ISSN 1545-7885
Editor: PLOS
DOI: 10.1371/journal.pbio.3002315

Cell surface fluctuations regulate early embryonic lineage sorting

Autores: Ayaka Yanagida; Elena Corujo-Simon; Christopher K. Revell; Preeti Sahu; Giuliano G. Stirparo; Irene M. Aspalter; Alex K. Winkel; Ruby Peters; Henry De Belly; Davide A.D. Cassani; Sarra Achouri; Raphael Blumenfeld; Kristian Franze; Edouard Hannezo; Ewa K. Paluch; Jennifer Nichols; Kevin J. Chalut;
Publicado en: Cell, 2022, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2022.01.022

Cell fate coordinates mechano-osmotic forces in intestinal crypt formation

Autores: Yang, Qiutan; Xue, Shilei, Chan, Chii Jou, Rempfler Markus, Vischi Dario, Maurer-Gutierrez Francisca, Hiiragi, Takashi, Hannezo, Edouard, Liberali Prisca
Publicado en: Nature Cell Biology, 2021, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-021-00700-2

Theory of mechanochemical patterning and optimal migration in cell monolayers

Autores: Boocock, Daniel R, Hino Naoya, Ruzickova, Natalia, Hirashima, Tsuyoshi, Hannezo, Edouard
Publicado en: Nature Physics, 2021, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1038/s41567-020-01037-7

Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models

Autores: David B. Brückner, Edouard Hannezo
Publicado en: Cold Spring Harbor Perspectives in Biology, Edición 17, 2025, Página(s) a041653, ISSN 1943-0264
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041653

Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks

Autores: Mehmet Can Uçar, Edouard Hannezo, Emmi Tiilikainen, Inam Liaqat, Emma Jakobsson, Harri Nurmi, Kari Vaahtomeri
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-41456-7

Interplay between Mechanochemical Patterning and Glassy Dynamics in Cellular Monolayers

Autores: Daniel Boocock, Tsuyoshi Hirashima, Edouard Hannezo
Publicado en: PRX Life, Edición 1, 2023, ISSN 2835-8279
Editor: American Physical Society.
DOI: 10.1103/prxlife.1.013001

Geometry-driven migration efficiency of autonomous epithelial cell clusters

Autores: Eléonore Vercruysse, David B. Brückner, Manuel Gómez-González, Alexandre Remson, Marine Luciano, Yohalie Kalukula, Leone Rossetti, Xavier Trepat, Edouard Hannezo, Sylvain Gabriele
Publicado en: Nature Physics, Edición 20, 2024, Página(s) 1492-1500, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1038/s41567-024-02532-x

Self-generated chemotaxis of mixed cell populations

Autores: Mehmet Can Uçar, Zane Alsberga, Jonna Alanko, Michael Sixt, Edouard Hannezo
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2504064122

Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions

Autores: Nicoletta Petridou, Bernat Corominas-Murtra, Carl-Philipp Heisenberg, Edouard Hannezo
Publicado en: Cell, 2021, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2021.02.017

Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation

Autores: Lorena Redondo Morata; Marine Luciano; Shi-Lei Xue; Winnok H. De Vos; Lorena Morata; Mathieu Surin; Frank Lafont; Edouard Hannezo; Sylvain Gabriele
Publicado en: Nature Physics, 2021, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1101/2020.07.04.187468

Stem cell lineage survival as a noisy competition for niche access

Autores: Corominas-Murtra Bernat, Scheele Colinda, Kishi Kasumi Ellenbroek Saskia, Simons Benjamin, Van Rheenen Jacco, Hannezo, Edouard
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, 2021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1921205117

Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids

Autores: S. Randriamanantsoa, A. Papargyriou, H. C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E. Hannezo, M. Reichert, A. R. Bausch
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32806-y

Conference proceedings (1)

Non-canonical cytokinesis driven by mechanical uncoupling via nematic flows and adhesion-based invagination

Autores: Xin Tong, Yuting I. Li, Joséphine Schelle, Edouard Hannezo, Carl-Philipp Heisenberg
Publicado en: openRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.10.15.682552

Other (1)

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

Autores: C. Schwayer, S. Barbiero, D. B. Brückner, C. Baader, N. A. Repina, O. E. Diaz, L. Challet Meylan, V. Kalck, S. Suppinger, Q. Yang, J. Schnabl, U. Kilik, J. G. Camp, B. Stockinger, M. Bühler, M. B. Stadler, E. Hannezo, P. Liberali
Publicado en: bioRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.01.14.632683