Probing the mysteries of sweet “on-off” switches of the human immune system: toward the development of novel glycomimetics against bacterial infections

Project Information

GLYCOSWITCH

Grant agreement ID: 851356

DOI

10.3030/851356

EC signature date 10 October 2019

Start date 1 February 2020

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 994 117,50

EU contribution

€ 1 994 117,00

Coordinated by

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Molecular recognition of Escherichia coli R1-type core lipooligosaccharide by DC-SIGN

Author(s): Ferran Nieto-Fabregat, Angela Marseglia, Michel Thépaut, Jean-Philippe Kleman, Massilia Abbas, Aline Le Roy, Christine Ebel, Meriem Maalej, Jean-Pierre Simorre, Cedric Laguri, Antonio Molinaro, Alba Silipo, Franck Fieschi, Roberta Marchetti
Published in: iScience, Issue 27, 2024, Page(s) 108792, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2024.108792

Conformationally Constrained Sialyl Analogues as NewPotential Binders of h-CD22

Author(s): Rosa Ester Forgione, Ferran Fabregat Nieto, Cristina Di Carluccio, Francesco Milanesi, Martina Fruscella,Francesco Papi, Cristina Nativi, Antonio Molinaro,Pasquale Palladino,Simona Scarano,Maria Minunni, Marco Montefiori, Monica Civera,Sara Sattin, Oscar Francesconi,Roberta Marchetti,* and Alba Silipo
Published in: ChemBioChem, 2022, ISSN 1439-7633
Publisher: Wiley-VCH

Structure and properties of the exopolysaccharide isolated from Flavobacterium sp. Root935

Author(s): Marta Tiemblo-Martín, Valeria Pistorio, Pia Saake, Lisa Mahdi, María Asunción Campanero-Rhodes, Rocco Di Girolamo, Cristina Di Carluccio, Roberta Marchetti, Antonio Molinaro, Dolores Solís, Alga Zuccaro, Alba Silipo
Published in: Carbohydrate Polymers, Issue 343, 2024, Page(s) 122433, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2024.122433

Chemical Synthesis of Sialyl N-Glycans and Analysis of Their Recognition by Neuraminidase

Author(s): Asuka Shirakawa,Dr. Yoshiyuki Manabe,Dr. Roberta Marchetti,Kumpei Yano,Seiji Masui,Prof. Alba Silipo,Prof. Antonio Molinaro,Prof. Koichi Fukase
Published in: Angewandte Chemie International Edition, 2021, ISSN 0570-0833
Publisher: Wiley -VCH

Characterization of Natural and Synthetic Sialoglycans Targeting theHemagglutinin-Neuraminidase of Mumps Virus

Author(s): Rosa Ester Forgione, Cristina Di Carluccio, Francesco Milanesi, Marie Kubota, Ferran Fabregat Nieto, Antonio Molinaro, Takao Hashiguchi, Oscar Francesconi, Roberta Marchetti* and Alba Silipo*
Published in: Frontiers in Chemistry, 2021, ISSN 2296-2646
Publisher: Frontiers

Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors

Author(s): Cristina Di Carluccio; Rosa Ester Forgione; Andrea Bosso; Shinji Yokoyama; Yoshiyuki Manabe; Elio Pizzo; Antonio Molinaro; Antonio Molinaro; Koichi Fukase; Marco Fragai; Barbara A. Bensing; Roberta Marchetti; Alba Silipo
Published in: RSC Chemical Biology, Issue 1, 2021, ISSN 2633-0679
Publisher: RSC
DOI: 10.1039/d1cb00173f

Computational toolbox for the analysis of protein–glycan interactions

Author(s): Ferran Nieto-Fabregat, Maria Pia Lenza, Angela Marseglia, Cristina Di Carluccio, Antonio Molinaro, Alba Silipo, Roberta Marchetti
Published in: Beilstein Journal of Organic Chemistry, Issue 20, 2024, Page(s) 2084-2107, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.20.180

Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody

Author(s): Peter T. Beernink, Cristina Di Carluccio, Roberta Marchetti, Linda Cerofolini, Sara Carillo, Alessandro Cangiano, Nathan Cowieson, Jonathan Bones, Antonio Molinaro, Luigi Paduano, Marco Fragai, Benjamin P. Beernink, Sunita Gulati, Jutamas Shaughnessy, Peter A. Rice, Sanjay Ram, Alba Silipo
Published in: JACS Au, Issue 4, 2024, Page(s) 2617-2629, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.4c00359

Atomic-Level Dissection of DC-SIGN Recognition of <i>Bacteroides vulgatus</i> LPS Epitopes

Author(s): Ferran Nieto-Fabregat, Qian Zhu, Corinne Vivès, Yunqin Zhang, Angela Marseglia, Fabrizio Chiodo, Michel Thépaut, Diksha Rai, Suvarn S. Kulkarni, Flaviana Di Lorenzo, Antonio Molinaro, Roberta Marchetti, Franck Fieschi, Guozhi Xiao, Biao Yu, Alba Silipo
Published in: JACS Au, Issue 4, 2024, Page(s) 697-712, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00748

Liquid-state NMR spectroscopy for complex carbohydrate structuralanalysis: A hitchhiker's guide

Author(s): ImmacolataSpeciale, AnnaNotaro, PilarGarcia-Vello, FlavianaDi Lorenzo, SamanthaArmiento, AntonioMolinaro, RobertaMarchetti, AlbaSilipo, CristinaDe Castro
Published in: Carbohydrate Polymers, 2021, ISSN 0144-8617
Publisher: Pergamon Press Ltd.

Solving the structural puzzle of bacterial glycome

Author(s): Roberta Marchetti, Rosa Ester Forgione, Ferran Nieto Fabregat, Cristina Di Carluccio, Antonio Molinaro, Alba Silipo
Published in: Current Opinion in Structural Biology, Issue 68, 2021, Page(s) 74-83, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.003

Tumor Carbohydrate Associated Antigen Analogs as Potential Binders for Siglec‐7

Author(s): Cristina Di Carluccio, Francesco Milanesi, Monica Civera, Celeste Abreu, Sara Sattin, Oscar Francesconi, Antonio Molinaro, Ondřej Vaněk, Roberta Marchetti, Alba Silipo
Published in: European Journal of Organic Chemistry, Issue 26, 2024, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202300644

Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR_UB10712) of <i>Streptococcus gordonii</i>

Author(s): Cristina Di Carluccio, Linda Cerofolini, Miguel Moreira, Frédéric Rosu, Luis Padilla-Cortés, Giulia Roxana Gheorghita, Zhuojia Xu, Abhishek Santra, Hai Yu, Shinji Yokoyama, Taylor E. Gray, Chris D. St. Laurent, Yoshiyuki Manabe, Xi Chen, Koichi Fukase, Matthew S. Macauley, Antonio Molinaro, Tiehai Li, Barbara A. Bensing, Roberta Marchetti, Valérie Gabelica, Marco Fragai, Alba Silipo
Published in: ACS Central Science, Issue 10, 2024, Page(s) 447-459, ISSN 2374-7943
Publisher: ACS publications
DOI: 10.1021/acscentsci.3c01598

Exploring the Molecular Interactions of Symmetrical andUnsymmetrical Selenoglycosides with Human Galectin-1and Galectin-3

Author(s): Luciano Pirone, Ferran Nieto-Fabregat, Sonia Di Gaetano , Domenica Capasso, Rita Russo, Serena Traboni, Antonio Molinaro, Alfonso Iadonisi, Michele Saviano, Roberta Marchetti, Alba Silipo, Emilia Pedone
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23158273

Expanding Knowledge of Methylotrophic Capacity: Structure andProperties of the Rough-Type Lipopolysaccharide fromMethylobacterium extorquens and Its Role on Membrane Resistanceto Methanol

Author(s): Flaviana Di Lorenzo, Simone Nicolardi, Roberta Marchetti, Adele Vanacore, Noemi Gallucci, Katarzyna Duda, Ferran Nieto Fabregat, Ha Ngoc Anh Nguyen, Djamel Gully, James Saenz, Eric Giraud, Luigi Paduano, Antonio Molinaro, Gerardino D’Errico, Alba Silipo
Published in: JACS Au, 2023, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00025

Role of EPS in mitigation of plant abiotic stress: The case ofMethylobacterium extorquens PA1

Author(s): AdeleVanacore, Maria ConcettaForgione, DomenicoCavasso, Ha Ngoc, Anh Nguyen, Antonio Molinaro, James P.Saenz, GerardinoD'Errico, LuigiPaduano, Roberta Marchetti, Alba Silipo
Published in: Carbohydrate polymers, 2022, ISSN 1879-1344
Publisher: Elsevier Ltd

Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis

Author(s): Dimitra Lamprinaki, Pilar Garcia-Vello, Roberta Marchetti, Charlotte Hellmich, Kelli A. McCord, Kristian M. Bowles, Matthew S. Macauley, Alba Silipo , Cristina De Castro, Paul R. Crocker and Nathalie Juge
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers

Antibody Recognition of Different Staphylococcus aureus Wall Teichoic Acid Glycoforms

Author(s): Cristina Di Carluccio, Pablo Soriano Maldonado, Francesca Berni, Carla J. C. de Haas, A. Robin Temming, Astrid Hendriks, Sara Ali, Antonio Molinaro, Alba Silipo, Nina M. van Sorge, Mark J. van Raaij, Jeroen D. C. Codee, Roberta Marchetti
Published in: ACS central science, 2022, ISSN 2374-7943
Publisher: ACS Publications

The unique 3D arrangement of macrophage galactose lectin enables <i>Escherichia coli</i> lipopolysaccharide recognition through two distinct interfaces

Author(s): Massilia Abbas, Meriem Maalej, Ferran Nieto-Fabregat, Michel Thépaut, Jean-Philippe Kleman, Isabel Ayala, Antonio Molinaro, Jean-Pierre Simorre, Roberta Marchetti, Franck Fieschi, Cedric Laguri
Published in: PNAS Nexus, Issue 2, 2023, ISSN 2752-6542
Publisher: PNAS Nexus
DOI: 10.1093/pnasnexus/pgad310

Molecular basis of bacterial lectin recognition of eukaryotic glycans: The case of Mycoplasma pneumoniae and Mycoplasma genitalium cytoadhesins

Author(s): Angela Marseglia, Maria Concetta Forgione, Marina Marcos-Silva, Cristina Di Carluccio, Yoshiyuki Manabe, David Vizarraga, Ferran Nieto-Fabregat, Maria Pia Lenza, Koichi Fukase, Antonio Molinaro, Oscar Q. Pich, David Aparicio, Alba Silipo, Roberta Marchetti
Published in: International Journal of Biological Macromolecules, Issue 279, 2024, Page(s) 135277, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.135277

Behavior of glycolylated sialoglycans in the bindingpockets of murine and human CD22

Author(s): CristinaDi Carluccio, Rosa EsterForgione, MarcoMontefiori, MonicaCivera, SaraSattin, GiovanniSmaldone, K.Fukase, Y.Manabe, Paul R.Crocker, AntonioMolinaro, RobertaMarchetti, AlbaSilipo
Published in: iScience, 2021, ISSN 2589-0042
Publisher: Elsevier

Semisynthetic Isomers of Fucosylated Chondroitin Sulfate Polysaccharides with Fucosyl Branches at a Non-Natural Site

Author(s): Giulia Vessella; Roberta Marchetti; Angela Del Prete; Serena Traboni; Alfonso Iadonisi; Chiara Schiraldi; Alba Silipo; Emiliano Bedini
Published in: Biomacromolecules, Issue 2, 2021, ISSN 1526-4602
Publisher: ACS
DOI: 10.1021/acs.biomac.1c01112

Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10

Author(s): Rosa Ester Forgione; Cristina Di Carluccio; Juan Guzmán-Caldentey; Rosa Gaglione; Filomena Battista; Fabrizio Chiodo; Yoshiyuki Manabe; Angela Arciello; Pompea Del Vecchio; Koichi Fukase; Antonio Molinaro; Sonsoles Martín-Santamaría; Paul R. Crocker; Roberta Marchetti; Alba Silipo
Published in: iScience, Vol 23, Iss 8, Pp 101401- (2020), Issue 1, 2020, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2020.101231

Investigation of protein-ligand complexes by ligand-based NMR methods

Author(s): Cristina Di Carluccio, Maria Concetta Forgione, Silvia Martini, Francesco Berti, Antonio Molinaro, Roberta Marchetti, Alba Silipo
Published in: Carbohydrate Research, 2021, ISSN 0008-6215
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carres.2021.108313

Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition

Author(s): Adele Vanacore; Giuseppe Vitiello; Alan Wanke; Domenico Cavasso; Luke A. Clifton; Lisa K. Mahdi; María Asunción Campanero-Rhodes; Dolores Solís; Manfred Wuhrer; Simone Nicolardi; Antonio Molinaro; Roberta Marchetti; Alga Zuccaro; Luigi Paduano; Alba Silipo
Published in: Carbohydrate Polymers, Issue 2, 2021, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2021.118839

Other (1)

Total Synthesis of the Zwitterionic Trisaccharide Repeating Unit of Fusobacterium nucleatum ATCC 51191 O-antigen

Author(s): Aishwarya Shelke, Amar Kumar Mishra, Bhaswati Ghosh, Roberta Marchetti, Alba Silipo, Suvarn Kulkarni
Published in: 2024
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-xplqh