CORDIS
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The evolution of menstruation in primates

Project information

Grant agreement ID: 851360

Status

Ongoing project

  • Start date

    1 July 2020

  • End date

    30 June 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 185 250

  • EU contribution

    € 1 185 250

Hosted by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Project description

English EN

Decoding the genetics of menstruation evolution in primates

The shedding of the superficial endometrium (menstruation) is a recent evolutionary attribute. It occurs only in few placental mammals (including humans and baboons), when in most other mammalian species the endometrium is reabsorbed at the end of the cycle. Scientists can’t explain this mechanism, but it is crucial for understanding gynaecological disorders. The EU-funded EVOMENS project will identify the gene networks and non-coding regulatory elements that control the advent of menstruation in primates. It will apply single-cell transcriptomics and deep transcriptomics to reconstruct the cellular developmental transition occurring in the uterus, model transcriptional dynamics and compare (at the cellular, functional and genetic levels) five primate species. EVOMENS will explain the evolutionary dynamics of the adoption of menstruation making the physiology of human reproduction more legible.

Host institution

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Research Organisations

EU Contribution

€ 1 185 250

Beneficiaries (1)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 1 185 250

Project information

Grant agreement ID: 851360

Status

Ongoing project

  • Start date

    1 July 2020

  • End date

    30 June 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 185 250

  • EU contribution

    € 1 185 250

Hosted by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France