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Therapeutic hijacking of E3 Ligases

Project description

Molecular glues induce target protein degradation by cooperative binding to E3 ligases

Recent discovery of the proteolysis-targeting chimeras (PROTACs), which are synthetic molecules recruiting target proteins to a ubiquitin ligase for ubiquitination and subsequent degradation, demonstrated how the rationally designed molecules enable targeting of a harmful protein substrate. The EU-funded project Glue2Degrade aims to transform the protein targeting in general, based on the hypothesis that molecular glues (MGs), small molecules that degrade target proteins through cooperative binding to E3 ligases, are much more prevalent than anticipated. Researchers will identify novel MGs and their E3 ligases by phenotypic discovery strategies and an orthogonal chemical genetics pipeline. The mechanisms of novel MGs will be studied using proteomics and chemical optimisation. Glue2Degrade's success will advance the potential for therapeutic development of cell-, tissue- and cancer-type specific chemical degraders for undruggable proteins.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

ERC-2019-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Address
Lazarettgasse 14 Akh Bt 25.3
1090 Wien
Austria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 331 340

Beneficiaries (1)

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Austria
EU contribution
€ 1 331 340
Address
Lazarettgasse 14 Akh Bt 25.3
1090 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)