Skip to main content
European Commission logo
English English
CORDIS - EU research results
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary

Therapeutic hijacking of E3 Ligases

Publications

Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling.

Author(s): Amanda Ng. Fabian Offensperger, Jose A. Cisneros, Natalie S. Scholes, Monika Malik, Ludovica Villanti, Andrea Rukavina, Evandro Ferrada, J. Thomas Hannich, Anna Koren, Stefan Kubicek, Giulio Superti-Furga, Georg E. Winter
Published in: ACS Chemical Biology, Issue 18(12), 2023, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.3c00598

Rational discovery of molecular glue degraders via scalable chemical profiling

Author(s): Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H. Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C. Müller, Johannes Zuber, Matthias Geyer, Nicolas H. Thomä, Stefan Kubicek, Georg E. Winter
Published in: Nature Chemical Biology, Issue 16/11, 2020, Page(s) 1199-1207, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0594-x

Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Author(s): Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Lara Dötsch, Hana Imrichova, Philipp Lampe, Xiufen Cheng, Soheila Rezaei Adariani, Georg E. Winter & Herbert Waldmann
Published in: Nature Communications, Issue 14(1), 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43657-6

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Author(s): Hanzl, A., Casement, R., Imrichova, H., Hughes, S. J., Barone, E., Testa, A., Bauer, S., Wright, J., Brand, M., Ciulli, A., & Winter, G. E.
Published in: Nature Chemical Biology, 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01177-2

Targeted protein degradation via intramolecular bivalent glues

Author(s): Hsia O., Hinterndorfer M., Cowan A. D., Iso, K., Ishida T., Sundaramoorthy R., Nakasone M. A., Imrichova H., Schätz C., Rukavina A., Husnjak K., Wegner M., Correa-Sáez A., Craigon C., Casement R., Maniaci C., Testa A., Kaulich M., Dikic I., Winter G. E., Ciulli A.
Published in: Nature, Issue 627, 2024, Page(s) 204-211, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07089-6

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

Author(s): Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P. Nowak, Elisa Hahn, Eugenia V. Pankevich, Anna Koren, Stefan Kubicek, Eric S. Fischer, and Georg E. Winter
Published in: Journal of the American Chemical Society, Issue 2023 Jan, 2023, Page(s) 1176–1184, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c10784

Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence

Author(s): Miquel Duran-Frigola; Marko Cigler; Georg E. Winter
Published in: Journal of the American Chemical Society, Issue 145(5), 2023, Page(s) 2711-2732, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c11098

Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins

Author(s): Gary Tin, Marko Cigler, Matthias Hinterndorfer, Kevin D. Dong, Hana Imrichova, Steven P. Gygi, Georg E. Winter
Published in: Bioorganic & Medicinal Chemistry Letters, Issue Volume 107, 2024, ISSN 0960-894X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2024.129779

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation

Author(s): Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman & Georg E. Winter
Published in: Nature Communications, Issue 15(1), 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49739-3

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

Author(s): Natalie S Scholes, Cristina Mayor-Ruiz, Georg E Winter
Published in: Cell Chemical Biology, Issue Volume 28, Issue 7, 2021, Page(s) P1048-1060
Publisher: Elsevier Ltd
DOI: 10.1016/j.chembiol.2021.03.007

Proximity-inducing pharmacology

Author(s): Winter GE, Mayor-Ruiz C
Published in: Nature Chemical Biology, Issue 20(1), 2024, Page(s) 13-14, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-023-01492-2

Searching for OpenAIRE data...

There was an error trying to search data from OpenAIRE

No results available