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Therapeutic hijacking of E3 Ligases


Rational discovery of molecular glue degraders via scalable chemical profiling

Author(s): Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H. Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C. Müller, Johannes Zuber, Matthias Geyer, Nicolas H. Thomä, Stefan Kubicek, Georg E. Winter
Published in: Nature Chemical Biology, Issue 16/11, 2020, Page(s) 1199-1207, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0594-x

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Author(s): Hanzl, A., Casement, R., Imrichova, H., Hughes, S. J., Barone, E., Testa, A., Bauer, S., Wright, J., Brand, M., Ciulli, A., & Winter, G. E.
Published in: Nature Chemical Biology, 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01177-2

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

Author(s): Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P. Nowak, Elisa Hahn, Eugenia V. Pankevich, Anna Koren, Stefan Kubicek, Eric S. Fischer, and Georg E. Winter
Published in: Journal of the American Chemical Society, Issue 2023 Jan, 2023, Page(s) 1176–1184, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c10784

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

Author(s): Natalie S Scholes, Cristina Mayor-Ruiz, Georg E Winter
Published in: Cell Chemical Biology, Issue Volume 28, Issue 7, 2021, Page(s) P1048-1060
Publisher: Elsevier Ltd
DOI: 10.1016/j.chembiol.2021.03.007

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