Project description DEENESFRITPL There’s a lot more to odours than meets the nose The sense of smell is vital for animals and humans to detect chemicals in their environment. It influences food intake, reproduction and social behaviour. For instance, social chemosignals (olfactory cues from urine or body secretions) are efficient communication cues carrying important information such as territory ownership, resources’ locations and identity. The EU-funded sociOlfa project will investigate the brain-wide mechanisms underlying the contribution of social chemosignals to spatial and social memory in the mouse. Using advanced computational methods and technologies, the project will study the mechanism of spatial memory consolidation, track the brain substrates of individuals’ identity in mice, and test whether a coordination between olfactory and memory networks is essential to the formation of social recognition memory. Show the project objective Hide the project objective Objective Olfaction is a central sensory modality in most Mammals as it supports vital functions such as feeding, mating and social interactions. Social chemosignals (olfactory cues from urine or body secretions) are efficient communication cues carrying important information such as territory ownership, resources’ locations and identity. Remembering such information is a key advantage for individuals allowing them to adapt their behaviors based on prior experience. However, how social chemosignals are processed and stored in the brain for future recall is still unclear. This project aims at identifying the brain-wide mechanisms underlying the contribution of social chemosignals to spatial and social memory in the mouse. The hippocampus is a key brain region for these two fundamental memory functions and it shares direct anatomical connections with the olfactory system that processes social odors. Using advanced computational methods and cutting-edge technologies that enable recording and manipulating large neuronal ensembles in freely moving mice, we will: - shed light on the mechanisms of spatial memory consolidation: we hypothesize that a dialog between the olfactory cortex and the hippocampus during sleep underlies the memory of an environment marked by social scents.- track the brain substrates of individuals’ identity in mice and their dependence on olfactory inputs: we hypothesize that during social learning, the response of neuronal circuits (1) reflects the unique olfactory signature of the encountered individual, and that (2) it changes as this individual becomes familiar. - test whether a coordination between olfactory and memory networks is essential to the formation of social recognition memory. Overall, this project will provide important insights on the network mechanisms of memory function and will contribute to our understanding of social behaviors. Fields of science natural sciencescomputer and information sciencescomputational sciencenatural sciencesbiological scienceszoologymammalogy Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2019-STG - ERC Starting Grant Call for proposal ERC-2019-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Host institution CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Net EU contribution € 1 498 875,00 Address RUE MICHEL ANGE 3 75794 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 498 875,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 1 498 875,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 498 875,00
