Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease

Project Information

MyeFattyLiver

Grant agreement ID: 851908

DOI

10.3030/851908

Project closed

EC signature date 25 October 2019

Start date 1 December 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair

Author(s): Federico F. De Ponti, Anna Bujko, Zhuangzhuang Liu, Paul J. Collins, Sara Schuermans, Christian Maueroder, Seraja Amstelveen, Tinne Thoné, Liesbet Martens, John G. McKendrick, Pieter A. Louwe, Ana Sànchez Cruz, Wouter Saelens, Kylie P. Matchett, Kathryn J. Waller, Christian Zwicker, Aimée Bugler-Lamb, Bavo Vanneste, Fleur Parmentier, Mushida Binte Abdul Latib, Anneleen Remmerie, Lenard Kertesz,
Published in: Immunity, Issue 58, 2025, Page(s) 362-380.e10, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2025.01.002

Hepatic Macrophage Responses in Inflammation, a Function of Plasticity, Heterogeneity or Both?

Author(s): Christian Zwicker, Anna Bujko, Charlotte L. Scott
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.690813

Understanding the complex macrophage landscape in MASLD

Author(s): Federico F. De Ponti, Zhuangzhuang Liu, Charlotte L. Scott
Published in: JHEP Reports, Issue 6, 2024, Page(s) 101196, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101196

Macrophage Subsets in Obesity, Aligning the Liver and Adipose Tissue

Author(s): Anneleen Remmerie, Liesbet Martens, Charlotte L. Scott
Published in: Frontiers in Endocrinology, Issue 11, 2020, ISSN 1664-2392
Publisher: Frontiers in Endocrinology
DOI: 10.3389/fendo.2020.00259

Implementing distinct spatial proteogenomic technologies: opportunities, challenges, and key considerations

Author(s): Bram Verstappe, Charlotte L Scott
Published in: Clinical and Experimental Immunology, Issue 218, 2024, Page(s) 151-162, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxae077

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Author(s): Anneleen Remmerie, Liesbet Martens, Tinne Thoné, Angela Castoldi, Ruth Seurinck, Benjamin Pavie, Joris Roels, Bavo Vanneste, Sofie De Prijck, Mathias Vanhockerhout, Mushida Binte Abdul Latib, Lindsey Devisscher, Anne Hoorens, Johnny Bonnardel, Niels Vandamme, Anna Kremer, Peter Borghgraef, Hans Van Vlierberghe, Saskia Lippens, Edward Pearce, Yvan Saeys, Charlotte L. Scott
Published in: Immunity, 2020, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.08.004

Transcriptional regulation of DC fate specification

Author(s): Cédric Bosteels, Charlotte L. Scott
Published in: Molecular Immunology, Issue 121, 2020, Page(s) 38-46, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2020.02.021

Liver macrophages in health and disease

Author(s): Guilliams, Martin; Scott, Charlotte
Published in: Immunity, Issue 1, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.08.002

Osteopontin characterizes bile duct–associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

Author(s): Kevin De Muynck, Lander Heyerick, Federico F. De Ponti, Bart Vanderborght, Tim Meese, Sanne Van Campenhout, Leen Baudonck, Eva Gijbels, Pedro M. Rodrigues, Jesus M. Banales, Mette Vesterhuus, Trine Folseraas, Charlotte L. Scott, Mathieu Vinken, Malaïka Van der Linden, Anne Hoorens, Jo Van Dorpe, Sander Lefere, Anja Geerts, Filip Van Nieuwerburgh, Xavier Verhelst, Hans Van Vlierberghe, Lindsey Dev
Published in: Hepatology, Issue 79, 2024, Page(s) 269-288, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000557

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Author(s): Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Gonçalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J.F. Kaptein, Johan Ne
Published in: Cell, Issue Volume 185, Issue 2, 20 January 2022, 2022, Page(s) 379-396.e38, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.12.018

Book chapters (1)

Studying Macrophages in the Murine Steatotic Liver using Flow Cytometry and Confocal Microscopy

Author(s): Zhuangzhuang Liu, Pieter A Louwe, Charlotte L. Scott
Published in: Methods Mol. Biology: Tissue Resident Macrophages, 2024
Publisher: Springer
DOI: 10.1007/978-1-0716-3437-0_15