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Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease

Project description

Role of myeloid cells in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease is a broad term for liver conditions not associated with alcohol consumption, and is common around the world. Its initial stage might progress to non-alcoholic hepatitis, cirrhosis or hepatocellular carcinoma, leading in severe cases to liver transplantation. Hepatic myeloid cells including mononuclear phagocytes might play a critical role in activating the immune system and leading to inflammation. The EU-funded project will study the heterogeneity of hepatic mononuclear phagocytes to elucidate roles of their subtypes in the development and progression of non-alcoholic fatty liver disease. Single cell technologies and several modern in vivo tools will be used to understand the significance of the phenotypic and functional heterogeneity of myeloid cells in mice and men.

Field of science

  • /medical and health sciences/basic medicine/immunology

Call for proposal

ERC-2019-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

VIB VZW
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium
Activity type
Research Organisations
EU contribution
€ 1 500 000

Beneficiaries (1)

VIB VZW
Belgium
EU contribution
€ 1 500 000
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations