Project description
Dynamics of cell and extracellular matrix co-development and adaptation
Cells inside an organism have a highly dynamic interaction with the extracellular matrix. It is important not only during tissue formation but is also implicated in the development of various diseases, including cardiomyopathy and cancer. This dynamic interaction represents an unprecedented challenge in healthcare, especially in regenerative medicine. CoEvolve aims to unravel the fundamental biophysical principles behind cell-extracellular matrix dynamics to decipher mechanoadaptation. Research will involve cutting edge in vitro manipulation technology for independent and interactive studies of cells and the matrix to study how cells sense the environment, how matric remodelling affects mechanical properties, and how all these interactions translate into tissue formation. Outcomes are important for directing and facilitating future research in regenerative medicine and tissue reconstruction.
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Funding Scheme
ERC-STG - Starting Grant
