Deconstructing and rebuilding the evolution of cell and tissue mechanoadaptation

Project description

Dynamics of cell and extracellular matrix co-development and adaptation

Cells inside an organism have a highly dynamic interaction with the extracellular matrix. It is important not only during tissue formation but is also implicated in the development of various diseases, including cardiomyopathy and cancer. This dynamic interaction represents an unprecedented challenge in healthcare, especially in regenerative medicine. CoEvolve aims to unravel the fundamental biophysical principles behind cell-extracellular matrix dynamics to decipher mechanoadaptation. Research will involve cutting edge in vitro manipulation technology for independent and interactive studies of cells and the matrix to study how cells sense the environment, how matric remodelling affects mechanical properties, and how all these interactions translate into tissue formation. Outcomes are important for directing and facilitating future research in regenerative medicine and tissue reconstruction.

Field of science

/medical and health sciences/basic medicine/physiology

Funding Scheme

ERC-STG - Starting Grant

Host institution

TECHNISCHE UNIVERSITEIT EINDHOVEN

Address

Groene Loper 3
5612 AE Eindhoven
Netherlands

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 499 601

Website

Contact the organisation

Beneficiaries (1)

TECHNISCHE UNIVERSITEIT EINDHOVEN

Netherlands