Novel imaging technique for assessment of progressive retinal diseases
Non-invasive two-photon ophthalmoscopy has the potential to obtain information about retinal physiology and assist in the diagnosis of progressive outer retinal disease before vision is seriously impaired. This technique tracks the visual cycle via the transient fluorophore all-trans-retinol in rods and cones separately. The EU-funded TrackCycle.2P project aims to establish two-photon ophthalmoscopy as a method for visualisation of retina function in clinical applications. The goal is to develop an adaptive optics scanning laser ophthalmoscope optimised for safe two-photon imaging in the human eye and quantification of the visual cycle in response to stimulation. Successful development of this novel imaging technique will result in better understanding of normal and abnormal visual cycle function and retinal biochemistry in health and disease.
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