Project description
Your gastrointestinal inhabitants may indirectly modulate hypertension
According to the World Health Organization, more than 1 billion people globally have hypertension (high blood pressure) and fewer than 20 % of them have it under control. Hypertension can cause damage to numerous organs, including the heart, kidneys, brain and eyes, and it is a major cause of premature death. Scientists have recently shown a link between dietary salt intake and hypertension that is mediated by an immune response regulated by gut microbiota. The EU-funded HyperBiota project is untangling the complicated pathway from diet to immunity to hypertension with the goal of enabling personalised hypertension therapy based on microbiome-related immunonutrition. Aside from treating hypertension, it could significantly decrease hypertension-associated organ damage.
Objective
Essential hypertension damages organs such as the kidney, thereby leading to premature death. Beyond elevated blood pressure, hypertension is characterized by a pro-inflammatory immune response ahead of measurable organ damage. Activated immune cells infiltrate the kidney to cause tissue injury. However, inflammation is insufficiently addressed by todays drugs. Current treatments do not include the gut microbiota, its metabolites and the associated lymphoid tissue the largest immune cell reservoir in the body. We have recently shown for the first time that variations in dietary salt intake promote hypertension by modulating the immune system via the microbiota and its metabolites. Thus, the diet-microbiota axis is an important modulator of the immune response in hypertension. HyperBiota envisions a personalized, microbiome-guided immunonutrition for anti-inflammatory immunomodulation and organ protection in hypertension. It will explore the interplay between diet-dependent microbial metabolism in the intestine and the immune system in hypertension. By using an interdisciplinary approach, HyperBiota aims to 1) decipher the reciprocity of dietary composition, microbial community structure and metabolism, and immune response in hypertension. The identification of critical dietary and microbial components will enable targeted interventions. 2) Particular attention will be payed to worsening kidney function and how this affects microbial ecology and immune cell homeostasis. 3) It will investigate the extent to which the gut-associated lymphoid tissue contributes to the immune response in hypertension and its responsiveness to targeted interventions. 4) Knowledge gained in model systems will be translated and verified in mice associated with human microbial communities. Taking this approach, HyperBiota will cross borders and take a systems view on inflammation in hypertension to enable microbiome-guided immunonutrition for organ protection in hypertension.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences ecology
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10117 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.