Description du projet
Vos habitants gastro-intestinaux peuvent indirectement moduler l’hypertension
Selon l’Organisation mondiale de la santé, plus d’un milliard de personnes souffrent d’hypertension (pression artérielle élevée) à l’échelle mondiale et moins de 20 % d’entre elles la maîtrisent. L’hypertension peut endommager de nombreux organes, dont le cœur, les reins, le cerveau et les yeux, et elle est une cause majeure de décès prématuré. Les scientifiques ont récemment montré un lien entre la consommation de sel alimentaire et l’hypertension qui est induite par une immunoréaction régulée par le microbiote intestinal. Le projet HyperBiota, financé par l’UE, démêle le parcours compliqué qui mène du régime alimentaire à l’immunité et à l’hypertension, dans le but de permettre une thérapie personnalisée de l’hypertension basée sur l’immunonutrition liée au microbiome. Outre le traitement de l’hypertension, elle pourrait réduire considérablement les lésions organiques associées à l’hypertension.
Objectif
Essential hypertension damages organs such as the kidney, thereby leading to premature death. Beyond elevated blood pressure, hypertension is characterized by a pro-inflammatory immune response ahead of measurable organ damage. Activated immune cells infiltrate the kidney to cause tissue injury. However, inflammation is insufficiently addressed by today’s drugs. Current treatments do not include the gut microbiota, its metabolites and the associated lymphoid tissue – the largest immune cell reservoir in the body. We have recently shown for the first time that variations in dietary salt intake promote hypertension by modulating the immune system via the microbiota and its metabolites. Thus, the diet-microbiota axis is an important modulator of the immune response in hypertension. HyperBiota envisions a personalized, microbiome-guided immunonutrition for anti-inflammatory immunomodulation and organ protection in hypertension. It will explore the interplay between diet-dependent microbial metabolism in the intestine and the immune system in hypertension. By using an interdisciplinary approach, HyperBiota aims to 1) decipher the reciprocity of dietary composition, microbial community structure and metabolism, and immune response in hypertension. The identification of critical dietary and microbial components will enable targeted interventions. 2) Particular attention will be payed to worsening kidney function and how this affects microbial ecology and immune cell homeostasis. 3) It will investigate the extent to which the gut-associated lymphoid tissue contributes to the immune response in hypertension and its responsiveness to targeted interventions. 4) Knowledge gained in model systems will be translated and verified in mice associated with human microbial communities. Taking this approach, HyperBiota will cross borders and take a systems view on inflammation in hypertension to enable microbiome-guided immunonutrition for organ protection in hypertension.
Champ scientifique
Programme(s)
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Régime de financement
ERC-STG - Starting GrantInstitution d’accueil
10117 Berlin
Allemagne