Modelling to Optimize Vector Elimination: Destabilising mosquito populations

Información del proyecto

MOVE

Identificador del acuerdo de subvención: 852957

DOI

10.3030/852957

Fecha de la firma de la CE 30 Octubre 2019

Fecha de inicio 1 Febrero 2020

Fecha de finalización 30 Noviembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 259 763,00

Aportación de la UE

€ 1 259 763,00

Coordinado por

UNIVERSITY OF GLASGOW
United Kingdom

Periodic Reporting for period 4 - MOVE (Modelling to Optimize Vector Elimination: Destabilising mosquito populations)

Período documentado: 2024-08-01 hasta 2026-01-31

Resumen del contexto y de los objetivos generales del proyecto

Vector control is the ubiquitous strategy against many of the most important vector-borne diseases such as malaria and dengue. Its sustainability and eventual success relies on our ability to understand how vector population dynamics and behaviour respond to those control interventions and human-mediated environmental changes. The project MOVE was designed to investigate the role of ecological dynamics in regulating mosquito populations occurring across three ecological scales; within-population, between-populations and within community, and how interventions could harness these processes to accelerate vector elimination. We will do this by developing and applying contemporary ecological models to a range of unique longitudinal entomological surveillance data sets, collected over decades as part of malaria surveillance and control programmes by our partners working in several African countries.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

We have the team in place and collated a range of unique longitudinal entomological and genomic data sets collected over decades as part of malaria surveillance and control programmes by our partners working in several African countries. Preliminary within-population simulation models have highlighted important trade-offs between density-dependence and allee effects in mosquito populations. These suggest that if we can identify a threshold when the Allee effects become active, it is possible to accelerate elimination of mosquito populations even when density-dependence is present. Between populations, preliminary results from genetic data indicate that there is population structuring in malaria mosquito population but whether this is a consequence of interventions or ecology requires further investigations. This ongoing work has been presented at various meetings and conferences.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

We expect that by the end of the project we will a deep understanding of how vector populations are regulated at different ecological scales and how vector control interventions impact those populations. We also expect to have a general framework to assess other vector populations. Specifically for improving vector control, examples of expected results within populations are the identification of thresholds for tipping into extinction vs rebound of vector populations, between populations we expect to determine how populations are structured over space and predict the optimal distribution of effort through space and time, and between species we expect to determine if a reduction the target species leads to higher or lower community disease transmission capacity. Broadly, we expect to identify unanticipated negative and positive effects of mosquito population suppression arising from a broad range of interventions.