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Site-selective protein-modification chemistries for antibody-drug conjugates (ADCs)


Development of the project logo, website and promotional material

An essential project communication and promotional material will be produced, namely logo, Website, brochure nad a flyer,as to incresae awareness of the project among the community at the beneficiaries as well as interested stakeholders.

Widening KPI: Evolution of the publications in high impact journals in the SIMICA research field

"To evaluate the impact of SIMICA activities, the Widening KPI: ""Evolution of the publications in high impact journals in the relevant research fields""was defined by the EC. This indicator measures the evolution (compared to a reference period of three years prior to the signature of the grant agreement) in % of the peer-reviewed publications in high impact journals (in the top 10% impact ranked journals) in the given research fields. The task will be to introduce in the Continuous reporting tool on the Funding and Tenders portal before the end of month 2 of the project peer-reviewed publications (in the particular field of research) of the coordinating entity during the three years preceding the start date of the project. "

Data Management Plan

The initial Data Management Plan for making their data findable, accessible, interoperable and reusable (FAIR). Our FAIR Data principles include details on i) Data description - nature, scope, scale; ii) security, access, sharing; iii) metadata and standards; iv) IPR; v) Ethical; vi) Formats; vii) Common data analysis packages; viii) archiving, preservation; ix) storage & back-up; x) compliance with national & EU legislation.

Searching for OpenAIRE data...


Tn Antigen Mimics Based on sp 2 -Iminosugars with Affinity for an anti-MUC1 Antibody

Author(s): Elena M. Sánchez Fernández, Claudio D. Navo, Nuria Martínez-Sáez, Rita Gonçalves-Pereira, Víctor J. Somovilla, Alberto Avenoza, Jesús H. Busto, Gonçalo J. L. Bernardes, Gonzalo Jiménez-Osés, Francisco Corzana, José M. García Fernández, Carmen Ortiz Mellet, Jesús M. Peregrina
Published in: Organic Letters, Issue 18/15, 2016, Page(s) 3890-3893, ISSN 1523-7060
DOI: 10.1021/acs.orglett.6b01899

Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?

Author(s): Sandra Casimiro, Arlindo Ferreira, André Mansinho, Irina Alho, Luis Costa
Published in: International Journal of Molecular Sciences, Issue 17/9, 2016, Page(s) 1415, ISSN 1422-0067
DOI: 10.3390/ijms17091415

Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels

Author(s): Tiago Rodrigues, Florian Sieglitz, Víctor J. Somovilla, Pedro M. S. D. Cal, Antony Galione, Francisco Corzana, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 55/37, 2016, Page(s) 11077-11081, ISSN 1433-7851
DOI: 10.1002/anie.201604336

Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide

Author(s): Diana Lousa, Antónia R. T. Pinto, Bruno L. Victor, Alessandro Laio, Ana S. Veiga, Miguel A. R. B. Castanho, Cláudio M. Soares
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep28099

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Published in: Parasitology, Issue 143/12, 2016, Page(s) 1543-1556, ISSN 0031-1820
DOI: 10.1017/s0031182016001153

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Author(s): Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E. Boucher, Fabrice F. B
Published in: PLOS Pathogens, Issue 12/7, 2016, Page(s) e1005763, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1005763

Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation

Author(s): Hélio Faustino, Maria J. S. A. Silva, Luís F. Veiros, Gonçalo J. L. Bernardes, Pedro M. P. Gois
Published in: Chemical Science, Issue 7/8, 2016, Page(s) 5052-5058, ISSN 2041-6520
DOI: 10.1039/c6sc01520d

Are there effective interventions to prevent hospital-acquired Legionnaires' disease or to reduce environmental reservoirs of Legionella in hospitals? A systematic review

Author(s): Dejanira Almeida, Elisabete Cristovam, Daniel Caldeira, Joaquim J. Ferreira, Teresa Marques
Published in: American Journal of Infection Control, Issue 44/11, 2016, Page(s) e183-e188, ISSN 0196-6553
DOI: 10.1016/j.ajic.2016.06.018

Droplet-microfluidics towards the assembly of advanced building blocks in cell mimicry

Author(s): Adam Armada-Moreira, Essi Taipaleenmäki, Fabian Itel, Yan Zhang, Brigitte Städler
Published in: Nanoscale, Issue 8/47, 2016, Page(s) 19510-19522, ISSN 2040-3364
DOI: 10.1039/c6nr07807a

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Author(s): Terzic, Natasa; Konstantinovic, Jelena; Tot, Miklos; Burojevic, Jovana; Djurkovic-Djakovic, Olgica; Srbljanovic, Jelena; Stajner, Tijana; Verbic, Tatjana; Zlatovic, Mario; Machado, Marta; Albuquerque, Ines S.; Prudencio, Miguel; Sciotii, Richard J.; Pecic, Stevan; D'Alessandro, Sarah; Taramelli, Donatella; Solaja, Bogdan A.
Published in: JOURNAL OF MEDICINAL CHEMISTRY, 2016, ISSN 0022-2623

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

Author(s): Sofia B. Carvalho, João M. Freire, Mafalda G. Moleirinho, Francisca Monteiro, Diana Gaspar, Miguel A. R. B. Castanho, Manuel J. T. Carrondo, Paula M. Alves, Gonçalo J. L. Bernardes, Cristina Peixoto
Published in: Bioconjugate Chemistry, Issue 27/10, 2016, Page(s) 2386-2399, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.6b00372

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

Author(s): Christopher Leija, Filipa Rijo-Ferreira, Lisa N. Kinch, Nick V. Grishin, Nicole Nischan, Jennifer J. Kohler, Zeping Hu, Margaret A. Phillips
Published in: PLOS Pathogens, Issue 12/11, 2016, Page(s) e1006010, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1006010

Novel squaramides with in vitro liver stage antiplasmodial activity

Author(s): Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
Published in: Bioorganic & Medicinal Chemistry, Issue 24/8, 2016, Page(s) 1786-1792, ISSN 0968-0896
DOI: 10.1016/j.bmc.2016.03.005

Flow Cytometry for Antimalarial Drug Testing: More than Meets the Eye

Author(s): Maria Rebelo, Thomas Hänscheid
Published in: Journal of Clinical Microbiology, Issue 54/3, 2016, Page(s) 817-817, ISSN 0095-1137
DOI: 10.1128/jcm.03017-15

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer

Author(s): Víctor J. Somovilla, Iris A. Bermejo, Inês S. Albuquerque, Nuria Martínez-Sáez, Jorge Castro-López, Fayna García-Martín, Ismael Compañón, Hiroshi Hinou, Shin-Ichiro Nishimura, Jesús Jiménez-Barbero, Juan L. Asensio, Alberto Avenoza, Jesús H. Busto, Ramón Hurtado-Guerrero, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Francisco Corzana
Published in: Journal of the American Chemical Society, Issue 139/50, 2017, Page(s) 18255-18261, ISSN 0002-7863
DOI: 10.1021/jacs.7b09447

Urban Endocrine Disruptors Targeting Breast Cancer Proteins

Author(s): Diana Montes-Grajales, Gonçalo J. L. Bernardes, Jesus Olivero-Verbel
Published in: Chemical Research in Toxicology, Issue 29/2, 2016, Page(s) 150-161, ISSN 0893-228X
DOI: 10.1021/acs.chemrestox.5b00342

Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

Author(s): Osmar N. Silva, Eliane S. F. Alves, César de la Fuente-Núñez, Suzana M. Ribeiro, Santi M. Mandal, Diana Gaspar, Ana S. Veiga, Miguel A. R. B. Castanho, Cesar A. S. Andrade, Jessica M. Nascimento, Isabel C. M. Fensterseifer, William F. Porto, Jose R. Correa, Robert. E. W. Hancock, Suresh Korpole, Aline L. Oliveira, Luciano M. Liao, Octavio L. Franco
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep27128

Site-selective protein-modification chemistry for basic biology and drug development

Author(s): Nikolaus Krall, Filipa P. da Cruz, Omar Boutureira, Gonçalo J. L. Bernardes
Published in: Nature Chemistry, Issue 8/2, 2016, Page(s) 103-113, ISSN 1755-4330
DOI: 10.1038/nchem.2393

Protein Quality Assessment on Saliva Samples for Biobanking Purposes

Author(s): Nuno Rosa, Jéssica Marques, Eduardo Esteves, Mónica Fernandes, Vera M. Mendes, Ângela Afonso, Sérgio Dias, Joaquim Polido Pereira, Bruno Manadas, Maria José Correia, Marlene Barros
Published in: Biopreservation and Biobanking, Issue 14/4, 2016, Page(s) 289-297, ISSN 1947-5535
DOI: 10.1089/bio.2015.0054

Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents

Author(s): Tiago Rodrigues, Florian Sieglitz, Gonçalo J. L. Bernardes
Published in: Chemical Society Reviews, Issue 45/22, 2016, Page(s) 6130-6137, ISSN 0306-0012
DOI: 10.1039/c5cs00916b

Plasmid-Borne Antimicrobial Resistance of Staphylococcus aureus Isolated in a Hospital in Lisbon, Portugal

Author(s): Sofia Santos Costa, Cláudia Palma, Kristina Kadlec, Andrea T. Fessler, Miguel Viveiros, José Melo-Cristino, Stefan Schwarz, Isabel Couto
Published in: Microbial Drug Resistance, Issue 22/8, 2016, Page(s) 617-626, ISSN 1076-6294
DOI: 10.1089/mdr.2015.0352

Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point

Author(s): Tiago Rodrigues
Published in: Organic & Biomolecular Chemistry, Issue 15/44, 2017, Page(s) 9275-9282, ISSN 1477-0520
DOI: 10.1039/c7ob02193c

Mass spectrometry-based plant metabolomics: Metabolite responses to abiotic stress

Author(s): Tiago F. Jorge, João A. Rodrigues, Camila Caldana, Romy Schmidt, Joost T. van Dongen, Jane Thomas-Oates, Carla António
Published in: Mass Spectrometry Reviews, Issue 35/5, 2016, Page(s) 620-649, ISSN 0277-7037
DOI: 10.1002/mas.21449

Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells

Author(s): A. S. Ribeiro, F. A. Carvalho, J. Figueiredo, R. Carvalho, T. Mestre, J. Monteiro, A. F. Guedes, M. Fonseca, J. Sanches, R. Seruca, N. C. Santos, J. Paredes
Published in: Nanoscale, Issue 8/46, 2016, Page(s) 19390-19401, ISSN 2040-3364
DOI: 10.1039/c6nr04465d

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

Author(s): Padma Akkapeddi, Saara-Anne Azizi, Allyson M. Freedy, Pedro M. S. D. Cal, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Published in: Chemical Science, Issue 7/5, 2016, Page(s) 2954-2963, ISSN 2041-6520
DOI: 10.1039/c6sc00170j

A Quality by design (QbD) approach on starch-based nanocapsules: A promising platform for topical drug delivery

Author(s): J. Marto, L.F. Gouveia, L.M. Gonçalves, D.P. Gaspar, P. Pinto, F.A. Carvalho, E. Oliveira, H.M. Ribeiro, A.J. Almeida
Published in: Colloids and Surfaces B: Biointerfaces, Issue 143, 2016, Page(s) 177-185, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2016.03.039

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

Author(s): Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M. Brindle, André A. Neves, Gonçalo J. L. Bernardes
Published in: Journal of the American Chemical Society, Issue 139/50, 2017, Page(s) 18365-18375, ISSN 0002-7863
DOI: 10.1021/jacs.7b10702

Primaquine-based ionic liquids as a novel class of antimalarial hits

Author(s): Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
Published in: RSC Advances, Issue 6/61, 2016, Page(s) 56134-56138, ISSN 2046-2069
DOI: 10.1039/c6ra10759a

Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates

Author(s): Raquel Santos, Diana Gomes, Hermes Macedo, Diogo Barros, Catarina Tibério, Ana Salomé Veiga, Luís Tavares, Miguel Castanho, Manuela Oliveira
Published in: Journal of Medical Microbiology, Issue 65/10, 2016, Page(s) 1092-1099, ISSN 0022-2615
DOI: 10.1099/jmm.0.000329

Serotype 3 Remains the Leading Cause of Invasive Pneumococcal Disease in Adults in Portugal (2012–2014) Despite Continued Reductions in Other 13-Valent Conjugate Vaccine Serotypes

Author(s): Andreia N. Horácio, Catarina Silva-Costa, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Published in: Frontiers in Microbiology, Issue 7, 2016, ISSN 1664-302X
DOI: 10.3389/fmicb.2016.01616

International multi-center evaluation of a novel chemiluminescence assay for the detection of anti-dsDNA antibodies

Author(s): C Bentow, G Lakos, P Martis, E Wahl, M Garcia, O Viñas, G Espinosa, R Cervera, C Sjöwall, D Carmona-Fernandes, M J Santos, J G Hanly, M Mahler
Published in: Lupus, Issue 25/8, 2016, Page(s) 864-872, ISSN 0961-2033
DOI: 10.1177/0961203316640917

A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells

Author(s): Bruno L. Oliveira, Zijian Guo, Omar Boutureira, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 55/47, 2016, Page(s) 14683-14687, ISSN 1433-7851
DOI: 10.1002/anie.201608438

Population Structure of Streptococcus pneumoniae Causing Invasive Disease in Adults in Portugal before PCV13 Availability for Adults: 2008-2011

Author(s): Andreia N. Horácio, Catarina Silva-Costa, Jorge Diamantino-Miranda, Joana P. Lopes, Mario Ramirez, José Melo-Cristino
Published in: PLOS ONE, Issue 11/5, 2016, Page(s) e0153602, ISSN 1932-6203
DOI: 10.1371/journal.pone.0153602

Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

Author(s): Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
Published in: Particle & Particle Systems Characterization, Issue 33/12, 2016, Page(s) 906-915, ISSN 0934-0866
DOI: 10.1002/ppsc.201600187

Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil

Author(s): Michael P. Crockett, Austin M. Evans, Max J. H. Worthington, Inês S. Albuquerque, Ashley D. Slattery, Christopher T. Gibson, Jonathan A. Campbell, David A. Lewis, Gonçalo J. L. Bernardes, Justin M. Chalker
Published in: Angewandte Chemie International Edition, Issue 55/5, 2016, Page(s) 1714-1718, ISSN 1433-7851
DOI: 10.1002/anie.201508708

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Author(s): E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Published in: Clinical Microbiology and Infection, Issue 22/4, 2016, Page(s) 379.e9-379.e16, ISSN 1198-743X
DOI: 10.1016/j.cmi.2015.11.020

Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide–membrane interactions of three related antimicrobial peptides

Author(s): Axel Hollmann, Melina Martínez, Martín E. Noguera, Marcelo T. Augusto, Anibal Disalvo, Nuno C. Santos, Liliana Semorile, Paulo C. Maffía
Published in: Colloids and Surfaces B: Biointerfaces, Issue 141, 2016, Page(s) 528-536, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2016.02.003

Camphor-based CCR5 blocker lead compounds – a computational and experimental approach

Author(s): Gonçalo C. Justino, Pedro F. Pinheiro, Alexandra P. S. Roseiro, Ana S. O. Knittel, João Gonçalves, Marta C. Justino, M. Fernanda N. N. Carvalho
Published in: RSC Advances, Issue 6/61, 2016, Page(s) 56249-56259, ISSN 2046-2069
DOI: 10.1039/c6ra09627a

Challenging metastatic breast cancer with the natural defensin Pv D 1

Author(s): Tiago N. Figueira, Filipa D. Oliveira, Inês Almeida, Érica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar
Published in: Nanoscale, Issue 9/43, 2017, Page(s) 16887-16899, ISSN 2040-3364
DOI: 10.1039/c7nr05872a

New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation

Author(s): Nádia Ribeiro, Somnath Roy, Nataliya Butenko, Isabel Cavaco, Teresa Pinheiro, Irina Alho, Fernanda Marques, Fernando Avecilla, João Costa Pessoa, Isabel Correia
Published in: Journal of Inorganic Biochemistry, Issue 174, 2017, Page(s) 63-75, ISSN 0162-0134
DOI: 10.1016/j.jinorgbio.2017.05.011

Radionuclides in oncology clinical practice – review of the literature

Author(s): Helena Luna Pais, Irina Alho, Inês Vendrell, André Mansinho, Luís Costa
Published in: Dalton Transactions, Issue 46/42, 2017, Page(s) 14475-14487, ISSN 1477-9226
DOI: 10.1039/c7dt01929g

Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells

Author(s): Gonzalo Scalese, M. Florencia Mosquillo, Santiago Rostán, Jorge Castiglioni, Irina Alho, Leticia Pérez, Isabel Correia, Fernanda Marques, João Costa Pessoa, Dinorah Gambino
Published in: Journal of Inorganic Biochemistry, Issue 175, 2017, Page(s) 154-166, ISSN 0162-0134
DOI: 10.1016/j.jinorgbio.2017.07.014

Protein engineering through chemical, genetic and computational manipulation

Author(s): Itaru Hamachi, Gonçalo J. L. Bernardes
Published in: Chemical Society Reviews, Issue 47/24, 2018, Page(s) 8977-8979, ISSN 0306-0012
DOI: 10.1039/c8cs90125b

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Author(s): Pedro M. S. D. Cal, Florian Sieglitz, Fábio M. F. Santos, Cátia Parente Carvalho, Ana Guerreiro, Jean B. Bertoldo, Uwe Pischel, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Published in: Chemical Communications, Issue 53/2, 2017, Page(s) 368-371, ISSN 1359-7345
DOI: 10.1039/c6cc08671c

Lipophilicity is a key factor to increase the antiviral activity of HIV neutralizing antibodies

Author(s): Marcelo T. Augusto, Axel Hollmann, Fulvia Troise, Ana S. Veiga, Antonello Pessi, Nuno C. Santos
Published in: Colloids and Surfaces B: Biointerfaces, Issue 152, 2017, Page(s) 311-316, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2017.01.032

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Author(s): Nuria Martínez-Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 56/47, 2017, Page(s) 14963-14967, ISSN 1433-7851
DOI: 10.1002/anie.201708847

Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents

Author(s): Goreti Ribeiro Morais, Elisa Palma, Fernanda Marques, Lurdes Gano, Maria Cristina Oliveira, Antero Abrunhosa, Hugo Vicente Miranda, Tiago F. Outeiro, Isabel Santos, Antonio Paulo
Published in: Journal of Heterocyclic Chemistry, Issue 54/1, 2017, Page(s) 255-267, ISSN 0022-152X
DOI: 10.1002/jhet.2575

New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity

Author(s): João Lopes, David Alves, Tânia S. Morais, Paulo J. Costa, M. Fátima M. Piedade, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia
Published in: Journal of Inorganic Biochemistry, Issue 169, 2017, Page(s) 68-78, ISSN 0162-0134
DOI: 10.1016/j.jinorgbio.2017.01.007

Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation

Author(s): Ricardo Sant’Anna, Maria Rosário Almeida, Nathalia Varejāo, Pablo Gallego, Sebastian Esperante, Priscila Ferreira, Alda Pereira-Henriques, Fernando L. Palhano, Mamede de Carvalho, Debora Foguel, David Reverter, Maria João Saraiva, Salvador Ventura
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/srep44709

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst

Author(s): Terence T.-L. Kwan, Omar Boutureira, Elizabeth C. Frye, Stephen J. Walsh, Moni K. Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F. Sore, Warren R. J. D. Galloway, Jason W. Chin, Martin Welch, Gonçalo J. L. Bernardes, David R. Spring
Published in: Chemical Science, Issue 8/5, 2017, Page(s) 3871-3878, ISSN 2041-6520
DOI: 10.1039/c6sc05313k

Inhibition of Plasmodium liver infection by ivermectin

Author(s): António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Published in: Antimicrobial Agents and Chemotherapy, 2017, Page(s) AAC.02005-16, ISSN 0066-4804
DOI: 10.1128/aac.02005-16

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Author(s): Ester Jiménez-Moreno, Zijian Guo, Bruno L. Oliveira, Inês S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 56/1, 2017, Page(s) 243-247, ISSN 1433-7851
DOI: 10.1002/anie.201609607

Potential of two delivery systems for nisin topical application to dental plaque biofilms in dogs

Author(s): Eva Cunha, Tiago Trovão, Ana Pinheiro, Telmo Nunes, Raquel Santos, Jorge Moreira da Silva, Berta São Braz, Luís Tavares, Ana Salomé Veiga, Manuela Oliveira
Published in: BMC Veterinary Research, Issue 14/1, 2018, ISSN 1746-6148
DOI: 10.1186/s12917-018-1692-9

Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length

Author(s): Marcelo Augusto, Axel Hollmann, Matteo Porotto, Anne Moscona, Nuno Santos
Published in: Molecules, Issue 22/7, 2017, Page(s) 1190, ISSN 1420-3049
DOI: 10.3390/molecules22071190

Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells

Author(s): Shuang Sun, Bruno L. Oliveira, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 57/48, 2018, Page(s) 15832-15835, ISSN 1433-7851
DOI: 10.1002/anie.201811338

Human Erythrocyte Acetylcholinesterase in Health and Disease

Author(s): Carlota Saldanha
Published in: Molecules, Issue 22/9, 2017, Page(s) 1499, ISSN 1420-3049
DOI: 10.3390/molecules22091499

Site-Selective Modification of Proteins with Oxetanes

Author(s): Omar Boutureira, Nuria Martínez-Sáez, Kevin M. Brindle, André A. Neves, Francisco Corzana, Gonçalo J. L. Bernardes
Published in: Chemistry - A European Journal, Issue 23/27, 2017, Page(s) 6483-6489, ISSN 0947-6539
DOI: 10.1002/chem.201700745

Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheel™ bioreactors

Author(s): Carlos AV Rodrigues, Teresa P Silva, Diogo ES Nogueira, Tiago G Fernandes, Yas Hashimura, Robin Wesselschmidt, Maria Margarida Diogo, Brian Lee, Joaquim MS Cabral
Published in: Journal of Chemical Technology & Biotechnology, Issue 93/12, 2018, Page(s) 3597-3606, ISSN 0268-2575
DOI: 10.1002/jctb.5738

Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Author(s): Annabel Kitowski, Ester Jiménez-Moreno, Míriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J. L. Bernardes
Published in: Organic Letters, Issue 19/19, 2017, Page(s) 5490-5493, ISSN 1523-7060
DOI: 10.1021/acs.orglett.7b02886

Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

Author(s): Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M. S. D. Cal, Sebyung Kang, Jung-Min Kee, Gonçalo J. L. Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong
Published in: Journal of the American Chemical Society, Issue 139/35, 2017, Page(s) 12121-12124, ISSN 0002-7863
DOI: 10.1021/jacs.7b06338

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Author(s): Jean B. Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A. Aprile, Marta C. Marques, Leonardo A. Rosado, Omar Boutureira, Thomas B. Steinbrecher, Woody Sherman, Francisco Corzana, Hernán Terenzi, Gonçalo J.L. Bernardes
Published in: Chem, Issue 3/4, 2017, Page(s) 665-677, ISSN 2451-9294
DOI: 10.1016/j.chempr.2017.07.009

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

Author(s): Tiago N. Figueira, João M. Freire, Catarina Cunha-Santos, Montserrat Heras, João Gonçalves, Anne Moscona, Matteo Porotto, Ana Salomé Veiga, Miguel A. R. B. Castanho
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/srep45647

Genetic Characterization of Listeria monocytogenes Isolates from Industrial and Retail Ready-to-Eat Meat-Based Foods and Their Relationship with Clinical Strains from Human Listeriosis in Portugal

Author(s): A. R. Henriques, J. Melo Cristino, M. J. Fraqueza
Published in: Journal of Food Protection, Issue 80/4, 2017, Page(s) 551-560, ISSN 0362-028X
DOI: 10.4315/0362-028x.jfp-16-310

Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol

Author(s): Bárbara Gomes, Nuno Santos, Matteo Porotto
Published in: Molecules, Issue 22/11, 2017, Page(s) 1869, ISSN 1420-3049
DOI: 10.3390/molecules22111869

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Author(s): Max J. H. Worthington, Renata L. Kucera, Inês S. Albuquerque, Christopher T. Gibson, Alexander Sibley, Ashley D. Slattery, Jonathan A. Campbell, Salah F. K. Alboaiji, Katherine A. Muller, Jason Young, Nick Adamson, Jason R. Gascooke, Deshetti Jampaiah, Ylias M. Sabri, Suresh K. Bhargava, Samuel J. Ippolito, David A. Lewis, Jamie S. Quinton, Amanda V. Ellis, Alexander Johs, Gonçalo J. L. Bernarde
Published in: Chemistry - A European Journal, Issue 23/64, 2017, Page(s) 16219-16230, ISSN 0947-6539
DOI: 10.1002/chem.201702871

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Author(s): Pedro M. S. D. Cal, Maria J. Matos, Gonçalo J. L. Bernardes
Published in: Expert Opinion on Therapeutic Patents, Issue 27/2, 2017, Page(s) 179-189, ISSN 1354-3776
DOI: 10.1080/13543776.2017.1259411

Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma

Author(s): Leonardo Ermini, Elena Morganti, Alexander Post, Behzad Yeganeh, Isabella Caniggia, Michael Leadley, Claudia C. Faria, James T. Rutka, Martin Post
Published in: PLOS ONE, Issue 12/5, 2017, Page(s) e0176254, ISSN 1932-6203
DOI: 10.1371/journal.pone.0176254

First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

Author(s): Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte
Published in: Antibiotics, Issue 7/4, 2018, Page(s) 96, ISSN 2079-6382
DOI: 10.3390/antibiotics7040096

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model

Author(s): Sara Neves-Coelho, Rute Eleutério, Francisco Enguita, Vera Neves, Miguel Castanho
Published in: Molecules, Issue 22/10, 2017, Page(s) 1753, ISSN 1420-3049
DOI: 10.3390/molecules22101753

Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity

Author(s): P. Maturana, M. Martinez, M.E. Noguera, N.C. Santos, E.A. Disalvo, L. Semorile, P.C. Maffia, A. Hollmann
Published in: Colloids and Surfaces B: Biointerfaces, Issue 153, 2017, Page(s) 152-159, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2017.02.003

Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Author(s): Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
Published in: Journal of Medicinal Chemistry, Issue 60/4, 2017, Page(s) 1432-1448, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.6b01641

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Author(s): Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Published in: Antimicrobial Agents and Chemotherapy, Issue 61/6, 2017, ISSN 0066-4804
DOI: 10.1128/aac.02699-16

siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model

Author(s): João Miguel Freire, Inês Rego de Figueiredo, Javier Valle, Ana Salomé Veiga, David Andreu, Francisco J. Enguita, Miguel A.R.B. Castanho
Published in: Journal of Controlled Release, Issue 245, 2017, Page(s) 127-136, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2016.11.027

Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18

Author(s): M.L. Pinto, E. Rios, A.C. Silva, S.C. Neves, H.R. Caires, A.T. Pinto, C. Durães, F.A. Carvalho, A.P. Cardoso, N.C. Santos, C.C. Barrias, D.S. Nascimento, P. Pinto-do-Ó, M.A. Barbosa, F. Carneiro, M.J. Oliveira
Published in: Biomaterials, Issue 124, 2017, Page(s) 211-224, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2017.02.004

Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites

Author(s): Jitka Dadová, Kuan-Jung Wu, Patrick G. Isenegger, James C. Errey, Gonçalo J. L. Bernardes, Justin M. Chalker, Lluís Raich, Carme Rovira, Benjamin G. Davis
Published in: ACS Central Science, Issue 3/11, 2017, Page(s) 1168-1173, ISSN 2374-7943
DOI: 10.1021/acscentsci.7b00341

Peptides with Dual Antimicrobial and Anticancer Activities

Author(s): Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Published in: Frontiers in Chemistry, Issue 5, 2017, ISSN 2296-2646
DOI: 10.3389/fchem.2017.00005

Poly(lactic acid)-based particulate systems are promising tools for immune modulation

Author(s): Carina Peres, Ana I. Matos, João Conniot, Vanessa Sainz, Eva Zupančič, Joana M. Silva, Luís Graça, Rogério Sá Gaspar, Véronique Préat, Helena F. Florindo
Published in: Acta Biomaterialia, Issue 48, 2017, Page(s) 41-57, ISSN 1742-7061
DOI: 10.1016/j.actbio.2016.11.012

"Quantification of cell cycle kinetics by EdU (5-ethynyl-2′-deoxyuridine)-coupled-fluorescence-intensity analysis"

Author(s): Pedro D. Pereira, Ana Serra-Caetano, Marisa Cabrita, Evguenia Bekman, José Braga, José Rino, Renè Santus, Paulo L. Filipe, Ana E. Sousa, João A. Ferreira
Published in: Oncotarget, Issue 8/25, 2017, ISSN 1949-2553
DOI: 10.18632/oncotarget.17121

Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX

Author(s): Christine Cruz-Oliveira, Andreza F. Almeida, João M. Freire, Marjolly B. Caruso, Maria A. Morando, Vivian N. S. Ferreira, Iranaia Assunção-Miranda, Andre M. O. Gomes, Miguel A. R. B. Castanho, Andrea T. Da Poian
Published in: Antimicrobial Agents and Chemotherapy, Issue 61/6, 2017, ISSN 0066-4804
DOI: 10.1128/aac.00053-17

Inverse electron demand Diels–Alder reactions in chemical biology

Author(s): B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Published in: Chemical Society Reviews, Issue 46/16, 2017, Page(s) 4895-4950, ISSN 0306-0012
DOI: 10.1039/c7cs00184c

The binding of free and copper-complexed fluoroquinolones to OmpF porins: an experimental and molecular docking study

Author(s): Sousa C. F., Coimbra J. T. S., Gomes I., Franco R., Fernandes P. A., Gameiro P.
Published in: RSC Advances, Issue 7/17, 2017, Page(s) 10009-10019, ISSN 2046-2069
DOI: 10.1039/c6ra26466b

Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk

Author(s): Ana F. Guedes, Filomena A. Carvalho, Carlos Moreira, José B. Nogueira, Nuno C. Santos
Published in: Nanoscale, Issue 9/39, 2017, Page(s) 14897-14906, ISSN 2040-3364
DOI: 10.1039/c7nr03891g

On the Assembly of Microreactors with Parallel Enzymatic Pathways

Author(s): Ana Armada-Moreira, Bo Thingholm, Kristine Andreassen, Ana M. Sebastião, Sandra H. Vaz, Brigitte Städler
Published in: Advanced Biosystems, Issue 2/5, 2018, Page(s) 1700244, ISSN 2366-7478
DOI: 10.1002/adbi.201700244

Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties

Author(s): Thais P. Pivetta, Sandra Simões, Margarete M. Araújo, Tânia Carvalho, Caroline Arruda, Priscyla D. Marcato
Published in: Colloids and Surfaces B: Biointerfaces, Issue 164, 2018, Page(s) 281-290, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2018.01.053

Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens

Author(s): Natacha Couto, Leonard Schuele, Erwin C. Raangs, Miguel P. Machado, Catarina I. Mendes, Tiago F. Jesus, Monika Chlebowicz, Sigrid Rosema, Mário Ramirez, João A. Carriço, Ingo B. Autenrieth, Alex W. Friedrich, Silke Peter, John W. Rossen
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-31873-w

Advanced 3D Analysis and Optimization of Single-Molecule FISH in Drosophila Muscle

Author(s): Akiko Noma, Carlas S. Smith, Maximiliaan Huisman, Robert M. Martin, Melissa J. Moore, David Grunwald
Published in: Small Methods, Issue 2/9, 2018, Page(s) 1700324, ISSN 2366-9608
DOI: 10.1002/smtd.201700324

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

Author(s): Patrícia M. Carvalho, Mário R. Felício, Nuno C. Santos, Sónia Gonçalves, Marco M. Domingues
Published in: Frontiers in Chemistry, Issue 6, 2018, ISSN 2296-2646
DOI: 10.3389/fchem.2018.00237

Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition

Author(s): Bárbara Gomes, Sónia Gonçalves, Anibal Disalvo, Axel Hollmann, Nuno C. Santos
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1860/5, 2018, Page(s) 1171-1178, ISSN 0005-2736
DOI: 10.1016/j.bbamem.2018.02.001

Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015

Author(s): Elísia Lopes, Tânia Fernandes, Miguel P Machado, João André Carriço, José Melo-Cristino, Mário Ramirez, Elisabete R Martins
Published in: Eurosurveillance, Issue 23/21, 2018, ISSN 1560-7917
DOI: 10.2807/

Immobilization of UDP-Galactose on an Amphiphilic Resin

Author(s): Jessica G. M. Bevan, Eva C. Lourenço, Miguel Chaves-Ferreira, João A. Rodrigues, M. Rita Ventura
Published in: European Journal of Organic Chemistry, Issue 2018/7, 2018, Page(s) 908-914, ISSN 1434-193X
DOI: 10.1002/ejoc.201701620

Structure–Stability–Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

Author(s): Tiago N. Figueira, Diogo A. Mendonça, Diana Gaspar, Manuel N. Melo, Anne Moscona, Matteo Porotto, Miguel A. R. B. Castanho, Ana Salomé Veiga
Published in: ACS Nano, Issue 12/10, 2018, Page(s) 9855-9865, ISSN 1936-0851
DOI: 10.1021/acsnano.8b01422

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Author(s): Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Published in: European Journal of Medicinal Chemistry, Issue 149, 2018, Page(s) 69-78, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2018.02.048

A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging

Author(s): Benjamin J. Stenton, Bruno L. Oliveira, Maria J. Matos, Laura Sinatra, Gonçalo J. L. Bernardes
Published in: Chemical Science, Issue 9/17, 2018, Page(s) 4185-4189, ISSN 2041-6520
DOI: 10.1039/c8sc00256h

Sensing adhesion forces between erythrocytes and γ’ fibrinogen, modulating fibrin clot architecture and function

Author(s): Ana Filipa Guedes, Filomena A. Carvalho, Marco M. Domingues, Fraser L. Macrae, Helen R. McPherson, Nuno C. Santos, Robert A.S. Ariёns
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 14/3, 2018, Page(s) 909-918, ISSN 1549-9634
DOI: 10.1016/j.nano.2018.01.006

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Author(s): Lucas Robke, Tiago Rodrigues, Peter Schröder, Daniel J. Foley, Gonçalo J.L. Bernardes, Luca Laraia, Herbert Waldmann
Published in: Tetrahedron, Issue 74/35, 2018, Page(s) 4531-4537, ISSN 0040-4020
DOI: 10.1016/j.tet.2018.07.021

Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor

Author(s): Alexandra Carreira, João Boavida Ferreira, Iliana Pereira, João Ferreira, Paulo Filipe, Ricardo Boavida Ferreira, Sara Monteiro
Published in: Journal of Medical Microbiology, Issue 67/2, 2018, Page(s) 198-207, ISSN 0022-2615
DOI: 10.1099/jmm.0.000675

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom

Author(s): Clara Pérez-Peinado, Susana Almeida Dias, Marco M. Domingues, Aurélie H. Benfield, João Miguel Freire, Gandhi Rádis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, Sónia Troeira Henriques, Ana Salomé Veiga, David Andreu
Published in: Journal of Biological Chemistry, Issue 293/5, 2018, Page(s) 1536-1549, ISSN 0021-9258
DOI: 10.1074/jbc.ra117.000125

Norbornene probes for the study of cysteine oxidation

Author(s): Lisa J. Alcock, Kyle D. Farrell, Mawey T. Akol, Gregory H. Jones, Matthew M. Tierney, Holger B. Kramer, Tara L. Pukala, Gonçalo J.L. Bernardes, Michael V. Perkins, Justin M. Chalker
Published in: Tetrahedron, Issue 74/12, 2018, Page(s) 1220-1228, ISSN 0040-4020
DOI: 10.1016/j.tet.2017.11.011

Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods

Author(s): Hélia F. Jeremias, Diana Lousa, Axel Hollmann, Ana C. Coelho, Carla S. Baltazar, João D. Seixas, Ana R. Marques, Nuno C. Santos, Carlos C. Romão, Cláudio M. Soares
Published in: PLOS ONE, Issue 13/9, 2018, Page(s) e0204624, ISSN 1932-6203
DOI: 10.1371/journal.pone.0204624

The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases

Author(s): Stępień E, Marina C Costa, Szczepan Kurc, Anna Drożdż, Nuno Cortez-Dias, Francisco J Enguita
Published in: Acta Pharmacologica Sinica, Issue 39/7, 2018, Page(s) 1085-1099, ISSN 1671-4083
DOI: 10.1038/aps.2018.35

Development of Antibody-Directed Therapies: Quo Vadis ?

Author(s): Tiago Rodrigues, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 57/8, 2018, Page(s) 2032-2034, ISSN 1433-7851
DOI: 10.1002/anie.201712185

Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase

Author(s): Miguel Peixoto de Almeida, Pedro Quaresma, Susana Sousa, Cláudia Couto, Inês Gomes, Ludwig Krippahl, Ricardo Franco, Eulália Pereira
Published in: Physical Chemistry Chemical Physics, Issue 20/24, 2018, Page(s) 16761-16769, ISSN 1463-9076
DOI: 10.1039/c8cp03116a

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Author(s): Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
Published in: ChemistryOpen, Issue 7/8, 2018, Page(s) 624-638, ISSN 2191-1363
DOI: 10.1002/open.201800117

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides

Author(s): Shuang Sun, Ismael Compañón, Nuria Martínez-Sáez, João D. Seixas, Omar Boutureira, Francisco Corzana, Gonçalo J. L. Bernardes
Published in: ChemBioChem, Issue 19/1, 2018, Page(s) 48-52, ISSN 1439-4227
DOI: 10.1002/cbic.201700586

Bioorthogonal Decaging Reactions for Targeted Drug Activation

Author(s): Sarah Davies, Benjamin J. Stenton, Gonçalo J. L. Bernardes
Published in: CHIMIA International Journal for Chemistry, Issue 72/11, 2018, Page(s) 771-776, ISSN 0009-4293
DOI: 10.2533/chimia.2018.771

Sleeping sickness is a circadian disorder

Author(s): Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02484-2

Chemo- and Regioselective Lysine Modification on Native Proteins

Author(s): Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro M. S. D. Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J. Deery, Justin M. Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Journal of the American Chemical Society, Issue 140/11, 2018, Page(s) 4004-4017, ISSN 0002-7863
DOI: 10.1021/jacs.7b12874

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Author(s): Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Published in: Archives of Pharmacal Research, Issue 41/2, 2018, Page(s) 208-218, ISSN 0253-6269
DOI: 10.1007/s12272-017-1000-4

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

Author(s): Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H. G. da Cruz, Marta C. Marques, Padma Akkapeddi, Susana A. Lobo, Andreas Koeberle, Francisco Corzana, Eufrânio N. da Silva Júnior, Oliver Werz, Gonçalo J. L. Bernardes
Published in: Chemical Science, Issue 9/34, 2018, Page(s) 6899-6903, ISSN 2041-6520
DOI: 10.1039/c8sc02634c

Primaquine hybrids as promising antimycobacterial and antimalarial agents

Author(s): Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Published in: European Journal of Medicinal Chemistry, Issue 143, 2018, Page(s) 769-779, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2017.11.083

Conjugate vaccine serotypes persist as major causes of non-invasive pneumococcal pneumonia in Portugal despite declines in serotypes 3 and 19A (2012-2015)

Author(s): Andreia N. Horácio, Catarina Silva-Costa, Elísia Lopes, Mário Ramirez, José Melo-Cristino
Published in: PLOS ONE, Issue 13/11, 2018, Page(s) e0206912, ISSN 1932-6203
DOI: 10.1371/journal.pone.0206912

Abbreviated atovaquone-proguanil prophylaxis regimens in travellers after leaving malaria-endemic areas: A systematic review

Author(s): Jelmer Savelkoel, Klaas Hendrik Binnendijk, Rene Spijker, Michèle van Vugt, Kathrine Tan, Thomas Hänscheid, Patricia Schlagenhauf, Martin Peter Grobusch
Published in: Travel Medicine and Infectious Disease, Issue 21, 2018, Page(s) 3-20, ISSN 1477-8939
DOI: 10.1016/j.tmaid.2017.12.005

Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates

Author(s): Maria J. Matos, Carlos Labão-Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke, Gonçalo J. L. Bernardes
Published in: Chemistry - A European Journal, Issue 24/47, 2018, Page(s) 12250-12253, ISSN 0947-6539
DOI: 10.1002/chem.201800872

Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane

Author(s): T. N. Figueira, M. T. Augusto, K. Rybkina, D. Stelitano, M. G. Noval, O. E. Harder, A. S. Veiga, D. Huey, C. A. Alabi, S. Biswas, S. Niewiesk, A. Moscona, N. C. Santos, M. A. R. B. Castanho, M. Porotto
Published in: Bioconjugate Chemistry, Issue 29/10, 2018, Page(s) 3362-3376, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.8b00527

Designing improved active peptides for therapeutic approaches against infectious diseases

Author(s): Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Published in: Biotechnology Advances, Issue 36/2, 2018, Page(s) 415-429, ISSN 0734-9750
DOI: 10.1016/j.biotechadv.2018.01.004

Site-selective installation of an electrophilic handle on proteins for bioconjugation

Author(s): Bernadette Lee, Shuang Sun, Ester Jiménez-Moreno, André A. Neves, Gonçalo J.L. Bernardes
Published in: Bioorganic & Medicinal Chemistry, Issue 26/11, 2018, Page(s) 3060-3064, ISSN 0968-0896
DOI: 10.1016/j.bmc.2018.02.028

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Published in: Molecules, Issue 25/9, 2020, Page(s) 2219, ISSN 1420-3049
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
DOI: 10.3389/fchem.2020.00496

Analysis of Protein Oligomeric Species by Sucrose Gradients

Author(s): Sandra Tenreiro, Diana Macedo, Zrinka Marijanovic, Tiago Fleming Outeiro
Published in: Proteostasis, Issue 1449, 2016, Page(s) 331-339
DOI: 10.1007/978-1-4939-3756-1_21

Sulfur-limonene polysulfide: A material synthesized entirely from industrial byproducts and its use in removing toxic metals from water and soil

Author(s): Evans, Austin; Crockett, Michael; Worthington, Max; Albuquerque, Ines; Slattery, Ashley; Gibson, Christopher; Lewis, David; Campbell, Jonathan; Bernardes, Goncalo; Chalker, Justin


Author(s): Correia, J.; Gano, L.; Santos, I.; Serrano, I. D.; Santos, S.; Ribeiro, M.; Perazzo, J.; Tavares, I.; Heras, M.; Bardaji, E.; Castanho, M. A.; Oliveira, M. C.

Cytotoxic activity of phenanthroline salicylaldimine zinc(II) complexes

Author(s): Matos, Cristina P.; Alemu, Yemataw A.; Nunes, Patrique; Barroso, Sonia; Alho, Irina; Matos, Antonio P.; Marques, Fernanda; Pessoa, Joao Costa; Correia, Isabel

Mechanisms of bacterial membrane permeabilization of snake venom-derived peptides crotalicidin (Ctn) and Ctn[15-34]

Author(s): Perez-Peinado, Clara; Almeida Dias, Susana; Domingues, Marco M.; Benfield, Aurelie H.; Miguel Freire, Jodo; Radis-Baptista, Gandhi; Gaspar, Diana; Castanho, Miguel; Craik, David; Henriques, Sonia Troeira; Salome Veiga, Ana; Andreu, David

Trans-Blood brain barrier peptides to enhace delivery of therapeutic molecules to treat Alzheimer's disease

Author(s): Neves, Vera; Aires-Da-Silva, Frederico; Gano, Lurdes; Corte-Real, Sofia; Correia, Joao D. G.; Castanho, Miguel

PaMAP 1.9 and PaMAP 2: efficient multi-resistant antimicrobial peptides show evidence of anticancer activity

Author(s): Felicio, Mario R.; Franco, Octavio; Santos, Nuno C.; Goncalves, Snia

Activity of the viral-derived peptide pepR against Staphylococcus aureus biofilms and insights into the mechanism of action

Author(s): Pinto, Sandra N.; Dias, Susana Almeida; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu, David; Prieto, Manuel; Castanho, Miguel; Coutinho, Ana; Veiga, Ana Salome

Exploring the membrane activity of a designed antimicrobial peptide with fusogenic properties

Author(s): Makowski, Marcin; Felicio, Mario R.; Franco, Octavio; Goncalves, Sonia; Melo, Manuel N.; Santos, Nuno C.

Building linkerless ADCs and CO-releasing antibodies for cancer therapeutics

Author(s): Bernardes, Goncalo