Site-selective protein-modification chemistries for antibody-drug conjugates (ADCs)

Livrables

Development of the project logo, website and promotional material

An essential project communication and promotional material will be produced, namely logo, Website, brochure nad a flyer,as to incresae awareness of the project among the community at the beneficiaries as well as interested stakeholders.

Impact assessment by the end of the project and forecast of the following 3-year period

The defined KPIs will be assessed at the end of the action as to demonstrate a clear evolution and the impact of SIMICA at the coordinating institution

SIMICA Thematic Workshop
Public awareness campaign
"""Knowledge Transfer Zone"" through meetings between research institutions and enterprises"

Complementary to the training this event will actively promote innovation initiatives at IMM and stimulate young researchers to work towards bringing innovation to the market

Summary of all project publications

ALl publications resulting form this action will be published with Open Access and will be summarized within the report

SIMICA Joint Summer School

A joint summer school will be organised in IMM with a morning session with 2 lectures 15 hours each and an afternoon session for local industry and stakeholders An Entrepreneurial training session will also be included covering transferrable skills related to entrepreneurship which is an important aspect for translational researchers Small teams of our secondees will build an investment case complete with project plan and presentation that will be pitched to industry beneficiariespartners The investment case will be focused on our own research theme compelling relevant entrepreneurship thinking for the current research and involve a pitch and negotiation phase Our SME beneficiaries will discuss entrepreneurship transform inventions raise capital and global business with linked case studies which will be linked to our draft business plan

Widening KPI: Evolution of the publications in high impact journals in the SIMICA research field

"To evaluate the impact of SIMICA activities, the Widening KPI: ""Evolution of the publications in high impact journals in the relevant research fields""was defined by the EC. This indicator measures the evolution (compared to a reference period of three years prior to the signature of the grant agreement) in % of the peer-reviewed publications in high impact journals (in the top 10% impact ranked journals) in the given research fields. The task will be to introduce in the Continuous reporting tool on the Funding and Tenders portal before the end of month 2 of the project peer-reviewed publications (in the particular field of research) of the coordinating entity during the three years preceding the start date of the project. "

"„The industrial day"" related to nanochemistry applications"

The event joining academic and industrial partners sharing interests in nanochemistry applications will be organised

Data Management Plan

The initial Data Management Plan for making their data findable, accessible, interoperable and reusable (FAIR). Our FAIR Data principles include details on i) Data description - nature, scope, scale; ii) security, access, sharing; iii) metadata and standards; iv) IPR; v) Ethical; vi) Formats; vii) Common data analysis packages; viii) archiving, preservation; ix) storage & back-up; x) compliance with national & EU legislation.

Publications

Photodynamic Therapy in Combination with the Hepatitis B Core Virus-like Particles (HBc VLPs) to Prime Anticancer Immunity for Colorectal Cancer Treatment

Auteurs: Yang Hao; Zili Gu; Zhenfeng Yu; Timo Schomann; Sana Sayedipour; Julio C. Aguilar; Peter ten Dijke; Luis J. Cruz
Publié dans: Cancers, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112724

Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions

Auteurs: Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Publié dans: J Am Chem Soc, 2023, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.3c01960

Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles

Auteurs: Zhenfeng Yu; Yuanyuan He; Timo Schomann; Kefan Wu; Yang Hao; Ernst Suidgeest; Hong Zhang; Christina Eich; Luis J. Cruz;
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14040840

Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions.

Auteurs: Zawada, Zbigniew; Guo, Zijian; Oliveira, Bruno L; Navo, Claudio D; Li, He; Cal, Pedro MSD; Corzana, Francisco; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo JL
Publié dans: Bioconjugate Chemistry, 2021, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.17863/cam.72439

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Auteurs: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Publié dans: Biomaterials, Numéro 268, 2021, Page(s) 120580, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Auteurs: Zili Gu, Candido Da Silva, Koen Van der Maaden, Ferry Ossendorp, Luis Cruz
Publié dans: Pharmaceutics, Numéro 12/11, 2020, Page(s) 1054, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111054

Multifunctional Role of Lipids in Modulating the Tumorigenic Properties of 4T1 Breast Cancer Cells

Auteurs: Yuanyuan He; Somayeh Rezaei; Raimundo Fernandes de Araújo Júnior; Luis J. Cruz; Christina Eich
Publié dans: Int J Mol Sci, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084240

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Auteurs: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Publié dans: Molecules, Numéro 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Nanocarriers as a tool for the treatment of colorectal cancer

Auteurs: Ana Luiza C. de S. L. Oliveira; Timo Schomann; Lioe-Fee de Geus-Oei; Ellen Kapiteijn; Luis J. Cruz; Raimundo Fernandes de Araújo Júnior
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Side-by-side comparison of uPAR-targeting optical imaging antibodies and antibody fragments for fluorescence-guided surgery of solid tumors

Auteurs: Victor M Baart; Labrinus van Manen; Shadhvi S. Bhairosingh; F. A. Vuijk; Luisa Iamele; Hugo de Jonge; Claudia Scotti; Massimo Resnati; Robert A. Cordfunke; Peter J. K. Kuppen; Andrew P. Mazar; Jacobus Burggraaf; Alexander L. Vahrmeijer; Cornelis F. M. Sier;
Publié dans: Mol Imaging Biol, 2021, ISSN 1536-1632
Éditeur: Elsevier BV
DOI: 10.1007/s11307-021-01657-2

STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer

Auteurs: Rômulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnóbio A. Silva‐Júnior, Aurigena A. Araújo, Luis J. Cruz, Alan B. Chan, Raimundo F. Araújo Júnior
Publié dans: British Journal of Pharmacology, 2021, ISSN 0007-1188
Éditeur: Wiley-Blackwell
DOI: 10.1111/bph.15373

Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N -Propargyl Handles for Drug-Activation

Auteurs: Bruno L. Oliveira; Benjamin J Stenton; V B Unnikrishnan; Cátia Rebelo de Almeida; João Conde;
Publié dans: J Am Chem Soc, 2020, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.0c01622

Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors

Auteurs: Sousa, Bárbara B.; de Almeida, Cátia Rebelo; Barahona, Ana F.; Lopes, Raquel; Martins-Logrado, Ana; Cavaco, Marco; Neves, Vera; Carvalho, Luís A.R.; Labaõ-Almeida, Carlos; Coelho, Ana R.; Bento, Marta Leal; Lopes, Ricardo M.R.M.; Oliveira, Bruno L.; Castanho, Miguel A.R.B.; Neumeister, Peter; Deutsch, Alexander Vladimer, Gregory I.; Krall, Nikolaus; Joaõ, Cristina; Corzana, Francisco; Seixas,
Publié dans: ACS Pharmacol. Transl. Sci, 2022, ISSN 2575-9108
Éditeur: ACS
DOI: 10.1021/acsptsci.2c00163

AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model

Auteurs: Maria Laura de Souza Lima; Caroline Addison Carvalho Xavier de Medeiros; Gerlane Coelho Bernardo Guerra; Robson A.S. Santos; Michael Bader; Flavia Q. Pirih; Raimundo Fernandes de Araújo Júnior; Alan Chan; Luis J. Cruz; Gerly Anne de Castro Brito; Renata Ferreira de Carvalho Leitão; Éricka Janine Dantas da Silveira; Vinícius Barreto Garcia
Publié dans: Int J Mol Sci, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105217

Functionalized Nanoparticles Targeting Tumor-Associated Macrophages as Cancer Therapy

Auteurs: Yuanyuan He; Raimundo Fernandes de Araújo Júnior; Luis J. Cruz; Christina Eich;
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101670

Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Auteurs: Hao, Yang; Chung, Chih Kit; Gu, Zili; Schomann, Timo; Dong, Xiaoxu; Veld, Ruben V. Huis in ‘t; Camps, Marcel G. M.; ten Dijke, Peter; Ossendorp, Ferry A.; Cruz, Luis J.
Publié dans: Molecular Biomedicine, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1186/s43556-022-00086-z

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Auteurs: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Publié dans: Molecules, Numéro 25/9, 2020, Page(s) 2219, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Optically Coupled PtOEP and DPA Molecules Encapsulated into PLGA-Nanoparticles for Cancer Bioimaging

Auteurs: Olena Vepris; Christina Eich; Yansong Feng; Gastón Fuentes; Hong Zhang; Eric L. Kaijzel; Luis J. Cruz
Publié dans: Biomedicines, 2022, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines10051070

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Auteurs: Chih Kit Chung; Uwe Beekmann; Dana Kralisch; Katja Bierau; Alan Chan; Ferry Ossendorp; Luis J. Cruz
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071351

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Auteurs: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Publié dans: Frontiers in Chemistry, Numéro 8, 2020, ISSN 2296-2646
Éditeur: Front. Chem.
DOI: 10.3389/fchem.2020.00496

Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects

Auteurs: Ana Luiza C. de S. L. Oliveira, Alaine M. dos Santos-Silva, Arnóbio A. da Silva-Júnior, Vinícius B. Garcia, Aurigena A. de Araújo, Lioe-Fee de Geus-Oei, Alan B. Chan, Luis J. Cruz, Raimundo F. de Araújo Júnior
Publié dans: Journal of Nanoparticle Research, Numéro 22/5, 2020, ISSN 1388-0764
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s11051-020-04832-8

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Auteurs: Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Publié dans: Journal of Controlled Release, Numéro 323, 2020, Page(s) 1-11, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2020.03.050

Upconversion nanoparticle platform for efficient dendritic cell antigen delivery and simultaneous tracking

Auteurs: Zhenfeng Yu; Olena Vepris; Christina Eich; Yansong Feng; Ivo Que; Marcel G. M. Camps; Hong Zhang; Ferry A. Ossendorp; Luis J. Cruz;
Publié dans: Microchimica Acta, 2022, ISSN 1436-5073
Éditeur: SCIMAGO
DOI: 10.1007/s00604-022-05441-z

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Auteurs: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Publié dans: Molecules, Numéro 25/5, 2020, Page(s) 1181, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry

Auteurs: Vera F. C. Ferreira, Bruno L. Oliveira, Alice D’Onofrio, Carlos M. Farinha, Lurdes Gano, António Paulo, Gonçalo J. L. Bernardes, Filipa Mendes
Publié dans: Bioconjugate Chemistry, Numéro 32/1, 2021, Page(s) 121-132, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00551

De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Auteurs: Maria Rebelo, Cong Tang, Ana R Coelho, Carlos Labão-Almeida, Matthias M Schneider, Laurie Tatalick, Pedro Ruivo, Marta Pires de Miranda, Andreia Gomes, Tânia Carvalho et al.
Publié dans: The Journal of Infectious Diseases, 2023, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1093/infdis/jiad135

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Auteurs: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Publié dans: Pharmaceutics, Numéro 12/11, 2020, Page(s) 1022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Auteurs: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Publié dans: International Journal of Molecular Sciences, Numéro 22/11, 2021, Page(s) 5730, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Thermosensitive Injectable Hydrogels for Intra-Articular Delivery of Etanercept for the Treatment of Osteoarthritis

Auteurs: Jomarien García-Couce; Timo Schomann; Chih Kit Chung; Ivo Que; Carla Jorquera-Cordero; Gastón Fuentes; Amisel Almirall; Alan Chan; Luis J. Cruz
Publié dans: Gels, 2022, ISSN 2310-2861
Éditeur: MDPI
DOI: 10.3390/gels8080488

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