Human Placental Development and the Uterine Microenvironment

Project Information

HumanPlacenta

Grant agreement ID: 853546

DOI

10.3030/853546

Project closed

EC signature date 10 February 2020

Start date 1 March 2020

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 992 098,00

EU contribution

€ 1 992 098,00

Coordinated by

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy

Author(s): Qian Li, Andrew Sharkey, Megan Sheridan, Elisa Magistrati, Anna Arutyunyan, Oisin Huhn, Carmen Sancho-Serra, Holly Anderson, Naomi McGovern, Laura Esposito, Ridma Fernando, Lucy Gardner, Roser Vento-Tormo, Margherita Yayoi Turco, Ashley Moffett
Published in: Cell Stem Cell, Issue 31, 2025, Page(s) 181-195.e9, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2023.12.013

Organoid systems to study the human female reproductive tract and pregnancy

Author(s): Lama Alzamil, Konstantina Nikolakopoulou & Margherita Y. Turco
Published in: Cell Death & Differentiation, 2020, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-020-0565-5

Spatial multiomics map of trophoblast development in early pregnancy

Author(s): Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick C. K. Wong, Megan A. Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R. Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J. Wright, Elena Prigmore, Sarah A. Teichmann, Omer Ali Bayraktar, Ashley
Published in: Nature, Issue 616, 2023, Page(s) 143-151, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05869-0

Organoids of the female reproductive tract.

Author(s): Cindrilla Chumduri; Margherita Y. Turco
Published in: Journal of Molecular Medicine (Berlin, Germany), Issue 1, 2021, ISSN 0946-2716
Publisher: Springer Verlag
DOI: 10.1007/s00109-020-02028-0

Characterization of primary models of human trophoblast

Author(s): Megan A. Sheridan, Xiaohui Zhao, Ridma C. Fernando, Lucy Gardner, Vicente Perez-Garcia, Qian Li, Steven G. E. Marsh, Russell Hamilton, Ashley Moffett, Margherita Y. Turco
Published in: Development, Issue 148/21, 2021, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.199749

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author(s): Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C. Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, Krzysztof Polanski, Regina Hoo, Carmen Sancho-Serra, Tong Li, Kwasi Kwakwa, Elizabeth Tuck, Valentina Lorenzi, Hassan Massalha, Martin Prete, Vitalii Kleshchevnikov, Aleksandra Tarkowska, Tarryn Porter, Cecilia Icoresi Mazzeo, Stijn van Donge
Published in: Nature Genetics, Issue 53, 2025, Page(s) 1698-1711, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00972-2

Investigation of human trophoblast invasion in vitro

Author(s): Yassen Abbas, Margherita Y Turco, Graham J Burton, Ashley Moffett
Published in: Human Reproduction Update, 2020, ISSN 1460-2369
Publisher: Oxford University press
DOI: 10.1093/humupd/dmaa017

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

Author(s): Megan A Sheridan, Ridma C Fernando, Lucy Gardner, Michael S Hollinshead, Graham J Burton, Ashley Moffett, Margherita Y Turco
Published in: nature protocols, 2020, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-0381-x

Menstrual flow as a non-invasive source of endometrial organoids

Author(s): Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn J P Jones, Ashley Moffett, Graham J Burton, Margherita Y Turco
Published in: Communications Biology, 2021, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-02194-y

Modeling the human maternal-fetal interface

Author(s): Vladyslav Bondarenko, Margherita Yayoi Turco
Published in: Cell Stem Cell, Issue 32, 2025, Page(s) 1321-1345, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2025.08.004

Investigation of infertility using endometrial organoids

Author(s): Konstantina Nikolakopoulou, Margherita Y Turco
Published in: Reproduction, 2021, ISSN 1470-1626
Publisher: Society for Reproduction and Fertility
DOI: 10.1530/rep-20-0428