CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
The Enzymatic Assay and Characterization of cyt bc1 & bd inhibitors report will describe the assay, conditions and characterisation methodology of the enzymatic assay for testing cytochrome bc1 and cytochrome bd inhibitors.
In vitro activity report for new anti-bacterial compounds (se abrirá en una nueva ventana)The In vitro activity report for new anti-bacterial compounds will summarize the results of in vitro activity of newly identified compounds within the project against intracellular (MDR)-Mtb strains in human cells.
Purified Mtb cytochrome report (se abrirá en una nueva ventana)The Purified Mtb cytochrome report will describe the methodology and confirmation of the purified cytochrome bc1, bc1:aa3, and bd
Continuous enzymatic assay and screening report (se abrirá en una nueva ventana)The continuous enzymatic assay and screening report will describe the assay, conditions and characterisation methodology of the continuous enzymatic assay for testing Mtr inhibitors and the application in the High Throughput Screening campaign.
Decision on final compound FiH (se abrirá en una nueva ventana)Short summary and scientific explanation on the final decision of the compound that will be used in the FiH. Minutes of the steering committee meeting where this will be decided are included.
In vitro synergy report for current and new anti-bacterial compounds (se abrirá en una nueva ventana)The in vitro synergy report for current and new anti-bacterial compounds will summarize the results of in vitro synergy between antibiotics currently used in standard TB treatment regimens and newly identified anti-bacterial compounds against intracellular (MDR)-Mtb strains in human cells.
Bactericidal Activity report (se abrirá en una nueva ventana)The Bactericidal activity Report will describe the methodology used and the results of two-by-two drug combinations by short murine experiments.
Structures of cytochrome report (se abrirá en una nueva ventana)The Structure of cytochrome report will describe the structures revealed by Structural Biology of cytochrome bc1 and/or bc1:aa3 or bd.
HDT Target Identification and mode of action report (se abrirá en una nueva ventana)The HDT Target Identification and mode of action report will describe the process, the methodology and summarize the identified of targets and mode of actions of lead Host Directed Therapeutics compounds.
In vitro activity of single HDT compounds report (se abrirá en una nueva ventana)In vitro activity of single HDT compounds report will summarize the results of in vitro activity of single Host Directed Therapeutics compounds against intracellular MDRMtb strains in human cells
The website developed for communication of all RespiriTB activities will be active and online.
Publicaciones
Autores:
Teun van der Klugt, Robin H. G. A. van den Biggelaar, Anno Saris
Publicado en:
Critical Reviews in Microbiology, Edición 51, 2025, Página(s) 463-483, ISSN 1040-841X
Editor:
Taylor & Francis
DOI:
10.1080/1040841x.2024.2370979
Autores:
Amit K. Verma, Robbert Q. Kim, Dirk A. Lamprecht, Clara Aguilar-Pérez, Sarah Wong, Nicolas Veziris, Alexandra Aubry, José M. Bartolomé-Nebreda, Rodrigo J. Carbajo, Jennefer Wetzel, Meindert H. Lamers
Publicado en:
npj Drug Discovery, Edición 2, 2025, ISSN 3005-1452
Editor:
Springer Science and Business Media LLC
DOI:
10.1038/s44386-025-00008-3
Autores:
Natalia Smiejkowska, Lauren Oorts, Kevin Van Calster, Linda De Vooght, Rob Geens, Henri-Philippe Mattelaer, Koen Augustyns, Sergei V. Strelkov, Dirk Lamprecht, Koen Temmerman, Yann G.-J. Sterckx, Davie Cappoen, Paul Cos
Publicado en:
Microbiology Spectrum, Edición 12, 2024, ISSN 2165-0497
Editor:
American Society for Microbiology
DOI:
10.1128/spectrum.03723-23
Autores:
Clara Aguilar-Pérez, Anne J. Lenaerts, Cristina Villellas, Jerome Guillemont, John Dallow, Hannah Painter, Nicole C. Ammerman, Anis Hassan, Guillaume Golovkine, Laure Brock, Sylvie Sordello, Aurélie Chauffour, Alexandra Aubry, Thi Cuc Mai, Sarah Wong, Taane G. Clark, Kiyean Nam, Jeongjun Kim, Jinho Choi, Marjolein Crabbe, Jorge Esquivias, Nacer Lounis, Bart Stoops, Katie Amssoms, Jose M. Bartolo
Publicado en:
Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-025-64427-6
Autores:
Jennefer Wetzel, John Dallow, Ellie Davis, William H. Pearson, Stijn Daems, Matthias Govaerts, Joyce Hereijgers, Joke Sprangers, Barry Truebody, Valerie Maes, Vera van Hasselt, Annelies Leemans, Venugopal Pujari, Ann Vos, Carlos M. Martínez Viturro, José Enrique Gómez, Mirte Peeters, Michelle Gerber, Nandini Chhabra, Annelies Wouters, Melissa Everaerts, Hannah Painter, Raisha Fathima, Sam J. Wi
Publicado en:
Biorxiv, 2026, ISSN 2692-8205
Editor:
openRxiv
DOI:
10.64898/2026.02.10.702511
Autores:
Gül Kilinç, Anno Saris, Tom H. M. Ottenhoff, Mariëlle C. Haks
Publicado en:
Immunological Reviews, Edición 301/1, 2021, Página(s) 62-83, ISSN 0105-2896
Editor:
Blackwell Publishing Inc.
DOI:
10.1111/imr.12951
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