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ASsembly and phase Transitions of Ribonucleoprotein Aggregates in neurons: from physiology to pathology.

Project description

RNA and ribonucleoprotein aggregates in neurons

Recent studies implicate the pathogenic relevance of altered RNA metabolism and aberrant ribonucleoprotein (RNP) assembly in several neurodegenerative diseases. How defective RNPs form, what their integral components are and which events trigger their appearance late in life are still unsolved issues. The EU-funded ASTRA project will combine sophisticated imaging-derived RNP complex purification, genetic tools and innovative computational approaches to investigate the biophysical properties and composition of the complexes and how they are modified in disease conditions. The development of new imaging and optical methods will allow scientists to study the separation of RNPs in liquid and solid phases in cells, in tissues and animal models, and to characterise their RNA and protein components in physiological and pathological states.

Host institution

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Net EU contribution
€ 2 735 625,25
Address
Piazzale Aldo Moro 5
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
Net EU contribution
€ 2 735 625,25
Address
Piazzale Aldo Moro 5
00185 Roma

See on map

Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
Net EU contribution
€ 5 006 173,75
Address
Via Morego 30
16163 Genova

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Other funding
€ 0,00