Project description
RNA and ribonucleoprotein aggregates in neurons
Recent studies implicate the pathogenic relevance of altered RNA metabolism and aberrant ribonucleoprotein (RNP) assembly in several neurodegenerative diseases. How defective RNPs form, what their integral components are and which events trigger their appearance late in life are still unsolved issues. The EU-funded ASTRA project will combine sophisticated imaging-derived RNP complex purification, genetic tools and innovative computational approaches to investigate the biophysical properties and composition of the complexes and how they are modified in disease conditions. The development of new imaging and optical methods will allow scientists to study the separation of RNPs in liquid and solid phases in cells, in tissues and animal models, and to characterise their RNA and protein components in physiological and pathological states.
Fields of science
Topic(s)
Call for proposal
ERC-2019-SyG
See other projects for this call
Funding Scheme
ERC-SyG - Synergy grantHost institution
00185 Roma
Italy
Beneficiaries (2)
00185 Roma
16163 Genova
