Safety in NanOmaterials & NAnotechnology

Informations projet

SiNfONiA

N° de convention de subvention: 857253

DOI

10.3030/857253

Projet clôturé

Date de signature de la CE 20 Juin 2019

Date de début 1 Juin 2019

Date de fin 31 Decembre 2024

Financé au titre de

• Establishing ‚ERA Chairs’

Coût total

€ 2 498 581,25

Contribution de l’UE

€ 2 498 581,25

Coordonné par

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (5)

"SiNfONiA - Video #4"

Short video presenting the available throughput nanosafety assays at INL and identifuing potential uses and customers of such services. Short video no longer then 60'.

"SiNfONiA - Video #2"

Short video explaining the research focus of the Nanosofety research department at INL and the expected impacts of such research The video will be no longer then 60 an may rely on info graphics style

"SiNfONiA - Video #3"

Short video showing the main research outcomes of the Nanosafety reseacrh department at INL. Short video, no longer then 60'.

Dissemination kit

The dissemination kit will be composed by the following elements: - SiNfONiA project branding (incl. templates) - Press kit: presentation providing information about the project to be distributed to members of the media for promotional use - SiNfONiA brochure - Newsletter template First elements of the dissemination kit will be prepared by month 12 and will be further updated by month 24, 36, 48 and 60.

"SiNfONiA - Video #1"

Short video raising awareness about the nanosafety research topic and briefly introducing the nanosafety research department at INL Info grahics style may be used The video should be no longer then 60

Other (1)

Nanosafety digital platform

Web based tool for promoting networking, information sharing; for providing effective up-to-date data by on the ERA chair´s activities and for promoting collaborations at European and worldwide level. The digital platform will be a tool for linking the ERA Chair´s activities with all interested stakeholders and research communities in the nanosafety area. The platform will be open and all interested stakeholders can register.The platform will be integrated in the SiNfONiA web-site.

Publications

Peer reviewed articles (22)

Osteoblasts-derived exosomes as potential novel communicators in particle-induced periprosthetic osteolysis

Auteurs: Wanderson de Souza, S. Gemini-Piperni, Carolina Ruivo, Nuno Bastos, Sofia Almeida, Daniel Lopes, Patricia Cardoso, Maria Jose Oliveira, D. Rick Sumner, Ryan D. Ross, Joshua J. Jacobs, Jose Mauro Granjeiro, Maria Helena Fernandes, Luis A. Rocha, Sonia Melo, Ana R. Ribeiro
Publié dans: Materials Today Bio, Numéro 28, 2024, Page(s) 101189, ISSN 2590-0064
Éditeur: ELSEVIER
DOI: 10.1016/j.mtbio.2024.101189

A Nano-QSTR model to predict nano-cytotoxicity: an approach using human lung cells data

Auteurs: João Meneses, Michael González-Durruthy, Eli Fernandez-de-Gortari, Alla P. Toropova, Andrey A. Toropov, Ernesto Alfaro-Moreno
Publié dans: Particle and Fibre Toxicology, Numéro 20, 2023, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-023-00530-0

Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells

Auteurs: Wanderson de Souza, S. Gemini-Piperni, Liliana Grenho, Luís A. Rocha, José M. Granjeiro, Sonia A. Melo, Maria H. Fernandes, Ana R. Ribeiro
Publié dans: Biomaterials Science, Numéro 11, 2024, Page(s) 2427-2444, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2bm01854c

Probabilistic material flow analysis of released nano titanium dioxide in Mexico

Auteurs: Luis Mauricio Ortiz-Galvez, Alejandro Caballero-Guzman, Carla Lopes, Ernesto Alfaro-Moreno
Publié dans: NanoImpact, Numéro 35, 2025, Page(s) 100516, ISSN 2452-0748
Éditeur: ELSEVIER
DOI: 10.1016/j.impact.2024.100516

Particulate matter-induced oxidative stress – Mechanistic insights and antioxidant approaches reported in in vitro studies

Auteurs: Vânia Vilas-Boas, Nivedita Chatterjee, Andreia Carvalho, Ernesto Alfaro-Moreno
Publié dans: Environmental Toxicology and Pharmacology, Numéro 110, 2024, Page(s) 104529, ISSN 1382-6689
Éditeur: Elsevier BV
DOI: 10.1016/j.etap.2024.104529

Decoding the conformational binding of drug mixtures on ovalbumin: An integrated multimodal network

Auteurs: Michael González-Durruthy, Ramón Rial, Juan M. Ruso
Publié dans: International Journal of Biological Macromolecules, Numéro 261, 2024, Page(s) 129866, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.129866

Nanomaterial exposure, extracellular vesicle biogenesis and adverse cellular outcomes: A Scoping Review

Auteurs: Thais SM Lima, Wanderson Souza, Luths RO Geaquinto, Priscila L Sanches, Ewa L Stepień, João Meneses, Eli Fernández-de Gortari, Nicole Meisner-Kober, Martin Himly, José M Granjeiro, Ana R Ribeiro
Publié dans: Nanomaterials, Numéro 12, 2022, Page(s) 1231, ISSN 2079-4991
Éditeur: Basel: MDPI AG, 2011
DOI: 10.3390/nano12071231

Exploring the immunomodulatory properties of glucan particles in human primary cells

Auteurs: Sandra Jesus, João Panão Costa, Mariana Colaço, Filipa Lebre, Daniela Mateus, Ana Isabel Sebastião, Maria T. Cruz, Ernesto Alfaro-Moreno, Olga Borges
Publié dans: International Journal of Pharmaceutics, Numéro 655, 2024, Page(s) 123996, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.123996

Enhancing Transcutaneous Drug Delivery: Advanced Perspectives on Skin Models

Auteurs: Ana Ribeiro, Catarina Pereira-Leite, Catarina Rosado, Edlira Aruci, Helen E. Colley, Inge Kortekaas Krohn, Ioana Baldea, Ivana Pantelić, Joachim W. Fluhr, Sandra I. Simões, Snežana Savić, Sofia A. Costa Lima
Publié dans: JID Innovations, Numéro 5, 2025, Page(s) 100340, ISSN 2667-0267
Éditeur: ELSEVIER
DOI: 10.1016/j.xjidi.2024.100340

Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials

Auteurs: S. Costa, V. Vilas-Boas, F. Lebre, J.M. Granjeiro, C.M. Catarino, L. Moreira Teixeira, P. Loskill, E. Alfaro-Moreno, A.R. Ribeiro
Publié dans: Trends in Biotechnology, Numéro 41, 2024, Page(s) 1282-1298, ISSN 0167-7799
Éditeur: Elsevier BV
DOI: 10.1016/j.tibtech.2023.05.009

Eco‐Friendly Production of 2D Ti₃C₂T_x MXene and Cytotoxicity Mitigation Toward Biomedical Applications

Auteurs: Siva Nemala Sankar, Guilherme Araujo, João Fernandes, Fatima Cerqueira, Pedro Alpuim, Ana R. Ribeiro, Filipa Lebre, Ernesto Alfaro‐Moreno, Ernesto Placidi, Sergio Marras, Andrea Capasso
Publié dans: Advanced Materials Interfaces, Numéro 11, 2024, Page(s) 24, ISSN 2196-7350
Éditeur: Wiley
DOI: 10.1002/admi.202400203

Effect of NaOH etching and oxygen plasma treatments on surface characteristics and their potential to activate micro-arc oxidized TiO2 coatings

Auteurs: Natália A. Costa, Ana R. Ribeiro, André L. Rossi, Cláudia Monteiro, Paulo N. Lisboa-Filho, M. Cristina L. Martins
Publié dans: Applied Surface Science, Numéro 682, 2024, Page(s) 161748, ISSN 0169-4332
Éditeur: Elsevier BV
DOI: 10.1016/j.apsusc.2024.161748

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

Auteurs: Filipa Lebre; Nivedita Chatterjee; Samantha Costa; Eli Fernández-de-Gortari; Carla Lopes; João Meneses; Luís Ortiz; Ana R. Ribeiro; Vânia Vilas-Boas; Ernesto Alfaro-Moreno
Publié dans: Nanomaterials, Numéro 12, 2022, ISSN 2079-4991
Éditeur: Basel: MDPI AG, 2011
DOI: 10.3390/nano12111810

Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment

Auteurs: Priscila Laviola Sanches, Rosana Bizon Vieira Carias, Gutember Gomes Alves, Carolina Motter Catarino, Bruna Bosquetti, Meg Cristina De Castilho Costa, Andrezza Di Pietro Micali, Desirée Cigaran Schuck, José Mauro Granjeiro, Ana R. Ribeiro
Publié dans: Nanoscale Advances, Numéro 7, 2025, Page(s) 1353-1367, ISSN 2516-0230
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4na00804a

Effects of chemical <i>in vitro</i> activation versus fragmentation on human ovarian tissue and follicle growth in culture

Auteurs: Jie Hao, Tianyi Li, Manuel Heinzelmann, Elisabeth Moussaud-Lamodière, Filipa Lebre, Kaarel Krjutškov, Anastasios Damdimopoulos, Catarina Arnelo, Karin Pettersson, Ernesto Alfaro-Moreno, Cecilia Lindskog, Majorie van Duursen, Pauliina Damdimopoulou
Publié dans: Human Reproduction Open, Numéro 2024, 2024, ISSN 2399-3529
Éditeur: Oxford Academic
DOI: 10.1093/hropen/hoae028

Differential impact of diesel exhaust particles on glutamatergic and dopaminergic neurons in Caenorhabditis elegans: A neurodegenerative perspective

Auteurs: Nivedita Chatterjee, Michael González-Durruthy, Marta Daniela Costa, Ana R. Ribeiro, Vânia Vilas-Boas, Daniela Vilasboas-Campos, Patrícia Maciel, Ernesto Alfaro-Moreno
Publié dans: Environment International, Numéro 186, 2024, Page(s) 108597, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108597

In Vitro Cell Transformation Assays: A Valuable Approach for Carcinogenic Potentiality Assessment of Nanomaterials

Auteurs: Nivedita Chatterjee, Ernesto Alfaro-Moreno
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, Page(s) 8219, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24098219

The Effects of Titanium Dioxide Nanoparticles on Osteoblasts Mineralization: A Comparison between 2D and 3D Cell Culture Models

Auteurs: Gabriela de Souza Castro, Wanderson de Souza, Thais Suelen Mello Lima, Danielle Cabral Bonfim, Jacques Werckmann, Braulio Soares Archanjo, José Mauro Granjeiro, Ana Rosa Ribeiro, Sara Gemini-Piperni
Publié dans: Nanomaterials, Numéro 13, 2025, Page(s) 425, ISSN 2079-4991
Éditeur: DOAJ
DOI: 10.3390/nano13030425

Ambient black carbon particles in human ovarian tissue and follicular fluid

Auteurs: Eva Bongaerts, Katariina Mamia, Ilmatar Rooda, Richelle D. Björvang, Kiriaki Papaikonomou, Sebastian B. Gidlöf, Jan I. Olofsson, Marcel Ameloot, Ernesto Alfaro-Moreno, Tim S. Nawrot, Pauliina Damdimopoulou
Publié dans: Environment International, Numéro 179, 2024, Page(s) 108141, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108141

Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro

Auteurs: Eleftheria Maria Panagiotou, Anastasios Damdimopoulos, Tianyi Li, Elisabeth Moussaud-Lamodière, Mikael Pedersen, Filipa Lebre, Karin Pettersson, Catarina Arnelo, Kiriaki Papaikonomou, Ernesto Alfaro-Moreno, Cecilia Lindskog, Terje Svingen, Pauliina Damdimopoulou
Publié dans: Toxicology, Numéro 505, 2025, Page(s) 153815, ISSN 0300-483X
Éditeur: Elsevier BV
DOI: 10.1016/j.tox.2024.153815

Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistant Staphylococcus aureus, immunomodulatory and osteogenic

Auteurs: B. Costa, J. Coelho, V. Silva, H. Shahrour, N.A. Costa, A.R. Ribeiro, S.G. Santos, F. Costa, G. Martínez-de-Tejada, C. Monteiro, M.C.L. Martins
Publié dans: Acta Biomaterialia, Numéro 191, 2024, Page(s) 98-112, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2024.11.016

The system of self-consistent models based on quasi-SMILES as a tool to predict the potential of nano-inhibitors of human lung carcinoma cell line A549 for different experimental conditions

Auteurs: Alla P Toropova, João Meneses, Ernesto Alfaro-Moreno, Andrey A Toropov
Publié dans: Drug and Chemical Toxicology, Numéro 04, 2023, ISSN 0148-0545
Éditeur: Marcel Dekker Inc.
DOI: 10.1080/01480545.2023.2174986

Thesis and dissertations (3)

Estimation of probable environmental concentrations of released titanium dioxide nanoparticles in Mexico

Auteurs: Luis Mauricio Ortiz Galvez
Publié dans: MAster Thesis, 2022
Éditeur: University of the Basque Country (UPV/EHU)

Modulation of cellular responses mediated by extracellular vesicles mediated by nanomaterials

Auteurs: Thaís Suelen Mello Lima
Publié dans: 2021
Éditeur: National Institute of Metrology Quality and Technology

Development of a skin-on-a-chip device for toxicological evaluation of nanomaterials

Auteurs: Samantha Faria da Costa Oliveira
Publié dans: Numéro 1, 2022
Éditeur: Universidade

Monographic books (1)

tbd

Auteurs: Nivedita Chatterjee, Vânia Vilas-Boas, Filipa Lebre, Ana R. Ribeiro, S. Costa, S. Nogueira, M González-Durruthy, H. Coley, N. Oliva, R. De Vecchi, E. Alfaro-Moreno
Publié dans: Nanosafety: A Comprehensive Approach to Assess Nanomaterial Exposure on the Environment and Health, Numéro 2025, 2025, Page(s) all
Éditeur: Springer Nature