Safety in NanOmaterials & NAnotechnology

Project Information

SiNfONiA

Grant agreement ID: 857253

DOI

10.3030/857253

Project closed

EC signature date 20 June 2019

Start date 1 June 2019

End date 31 December 2024

Funded under

• Establishing ‚ERA Chairs’

Total cost

€ 2 498 581,25

EU contribution

€ 2 498 581,25

Coordinated by

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (5)

"SiNfONiA - Video #4"

Short video presenting the available throughput nanosafety assays at INL and identifuing potential uses and customers of such services. Short video no longer then 60'.

"SiNfONiA - Video #2"

Short video explaining the research focus of the Nanosofety research department at INL and the expected impacts of such research The video will be no longer then 60 an may rely on info graphics style

"SiNfONiA - Video #3"

Short video showing the main research outcomes of the Nanosafety reseacrh department at INL. Short video, no longer then 60'.

Dissemination kit

The dissemination kit will be composed by the following elements: - SiNfONiA project branding (incl. templates) - Press kit: presentation providing information about the project to be distributed to members of the media for promotional use - SiNfONiA brochure - Newsletter template First elements of the dissemination kit will be prepared by month 12 and will be further updated by month 24, 36, 48 and 60.

"SiNfONiA - Video #1"

Short video raising awareness about the nanosafety research topic and briefly introducing the nanosafety research department at INL Info grahics style may be used The video should be no longer then 60

Other (1)

Nanosafety digital platform

Web based tool for promoting networking, information sharing; for providing effective up-to-date data by on the ERA chair´s activities and for promoting collaborations at European and worldwide level. The digital platform will be a tool for linking the ERA Chair´s activities with all interested stakeholders and research communities in the nanosafety area. The platform will be open and all interested stakeholders can register.The platform will be integrated in the SiNfONiA web-site.

Publications

Peer reviewed articles (22)

Osteoblasts-derived exosomes as potential novel communicators in particle-induced periprosthetic osteolysis

Author(s): Wanderson de Souza, S. Gemini-Piperni, Carolina Ruivo, Nuno Bastos, Sofia Almeida, Daniel Lopes, Patricia Cardoso, Maria Jose Oliveira, D. Rick Sumner, Ryan D. Ross, Joshua J. Jacobs, Jose Mauro Granjeiro, Maria Helena Fernandes, Luis A. Rocha, Sonia Melo, Ana R. Ribeiro
Published in: Materials Today Bio, Issue 28, 2024, Page(s) 101189, ISSN 2590-0064
Publisher: ELSEVIER
DOI: 10.1016/j.mtbio.2024.101189

A Nano-QSTR model to predict nano-cytotoxicity: an approach using human lung cells data

Author(s): João Meneses, Michael González-Durruthy, Eli Fernandez-de-Gortari, Alla P. Toropova, Andrey A. Toropov, Ernesto Alfaro-Moreno
Published in: Particle and Fibre Toxicology, Issue 20, 2023, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-023-00530-0

Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells

Author(s): Wanderson de Souza, S. Gemini-Piperni, Liliana Grenho, Luís A. Rocha, José M. Granjeiro, Sonia A. Melo, Maria H. Fernandes, Ana R. Ribeiro
Published in: Biomaterials Science, Issue 11, 2024, Page(s) 2427-2444, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2bm01854c

Probabilistic material flow analysis of released nano titanium dioxide in Mexico

Author(s): Luis Mauricio Ortiz-Galvez, Alejandro Caballero-Guzman, Carla Lopes, Ernesto Alfaro-Moreno
Published in: NanoImpact, Issue 35, 2025, Page(s) 100516, ISSN 2452-0748
Publisher: ELSEVIER
DOI: 10.1016/j.impact.2024.100516

Particulate matter-induced oxidative stress – Mechanistic insights and antioxidant approaches reported in in vitro studies

Author(s): Vânia Vilas-Boas, Nivedita Chatterjee, Andreia Carvalho, Ernesto Alfaro-Moreno
Published in: Environmental Toxicology and Pharmacology, Issue 110, 2024, Page(s) 104529, ISSN 1382-6689
Publisher: Elsevier BV
DOI: 10.1016/j.etap.2024.104529

Decoding the conformational binding of drug mixtures on ovalbumin: An integrated multimodal network

Author(s): Michael González-Durruthy, Ramón Rial, Juan M. Ruso
Published in: International Journal of Biological Macromolecules, Issue 261, 2024, Page(s) 129866, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.129866

Nanomaterial exposure, extracellular vesicle biogenesis and adverse cellular outcomes: A Scoping Review

Author(s): Thais SM Lima, Wanderson Souza, Luths RO Geaquinto, Priscila L Sanches, Ewa L Stepień, João Meneses, Eli Fernández-de Gortari, Nicole Meisner-Kober, Martin Himly, José M Granjeiro, Ana R Ribeiro
Published in: Nanomaterials, Issue 12, 2022, Page(s) 1231, ISSN 2079-4991
Publisher: Basel: MDPI AG, 2011
DOI: 10.3390/nano12071231

Exploring the immunomodulatory properties of glucan particles in human primary cells

Author(s): Sandra Jesus, João Panão Costa, Mariana Colaço, Filipa Lebre, Daniela Mateus, Ana Isabel Sebastião, Maria T. Cruz, Ernesto Alfaro-Moreno, Olga Borges
Published in: International Journal of Pharmaceutics, Issue 655, 2024, Page(s) 123996, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.123996

Enhancing Transcutaneous Drug Delivery: Advanced Perspectives on Skin Models

Author(s): Ana Ribeiro, Catarina Pereira-Leite, Catarina Rosado, Edlira Aruci, Helen E. Colley, Inge Kortekaas Krohn, Ioana Baldea, Ivana Pantelić, Joachim W. Fluhr, Sandra I. Simões, Snežana Savić, Sofia A. Costa Lima
Published in: JID Innovations, Issue 5, 2025, Page(s) 100340, ISSN 2667-0267
Publisher: ELSEVIER
DOI: 10.1016/j.xjidi.2024.100340

Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials

Author(s): S. Costa, V. Vilas-Boas, F. Lebre, J.M. Granjeiro, C.M. Catarino, L. Moreira Teixeira, P. Loskill, E. Alfaro-Moreno, A.R. Ribeiro
Published in: Trends in Biotechnology, Issue 41, 2024, Page(s) 1282-1298, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2023.05.009

Eco‐Friendly Production of 2D Ti₃C₂T_x MXene and Cytotoxicity Mitigation Toward Biomedical Applications

Author(s): Siva Nemala Sankar, Guilherme Araujo, João Fernandes, Fatima Cerqueira, Pedro Alpuim, Ana R. Ribeiro, Filipa Lebre, Ernesto Alfaro‐Moreno, Ernesto Placidi, Sergio Marras, Andrea Capasso
Published in: Advanced Materials Interfaces, Issue 11, 2024, Page(s) 24, ISSN 2196-7350
Publisher: Wiley
DOI: 10.1002/admi.202400203

Effect of NaOH etching and oxygen plasma treatments on surface characteristics and their potential to activate micro-arc oxidized TiO2 coatings

Author(s): Natália A. Costa, Ana R. Ribeiro, André L. Rossi, Cláudia Monteiro, Paulo N. Lisboa-Filho, M. Cristina L. Martins
Published in: Applied Surface Science, Issue 682, 2024, Page(s) 161748, ISSN 0169-4332
Publisher: Elsevier BV
DOI: 10.1016/j.apsusc.2024.161748

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

Author(s): Filipa Lebre; Nivedita Chatterjee; Samantha Costa; Eli Fernández-de-Gortari; Carla Lopes; João Meneses; Luís Ortiz; Ana R. Ribeiro; Vânia Vilas-Boas; Ernesto Alfaro-Moreno
Published in: Nanomaterials, Issue 12, 2022, ISSN 2079-4991
Publisher: Basel: MDPI AG, 2011
DOI: 10.3390/nano12111810

Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment

Author(s): Priscila Laviola Sanches, Rosana Bizon Vieira Carias, Gutember Gomes Alves, Carolina Motter Catarino, Bruna Bosquetti, Meg Cristina De Castilho Costa, Andrezza Di Pietro Micali, Desirée Cigaran Schuck, José Mauro Granjeiro, Ana R. Ribeiro
Published in: Nanoscale Advances, Issue 7, 2025, Page(s) 1353-1367, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4na00804a

Effects of chemical <i>in vitro</i> activation versus fragmentation on human ovarian tissue and follicle growth in culture

Author(s): Jie Hao, Tianyi Li, Manuel Heinzelmann, Elisabeth Moussaud-Lamodière, Filipa Lebre, Kaarel Krjutškov, Anastasios Damdimopoulos, Catarina Arnelo, Karin Pettersson, Ernesto Alfaro-Moreno, Cecilia Lindskog, Majorie van Duursen, Pauliina Damdimopoulou
Published in: Human Reproduction Open, Issue 2024, 2024, ISSN 2399-3529
Publisher: Oxford Academic
DOI: 10.1093/hropen/hoae028

Differential impact of diesel exhaust particles on glutamatergic and dopaminergic neurons in Caenorhabditis elegans: A neurodegenerative perspective

Author(s): Nivedita Chatterjee, Michael González-Durruthy, Marta Daniela Costa, Ana R. Ribeiro, Vânia Vilas-Boas, Daniela Vilasboas-Campos, Patrícia Maciel, Ernesto Alfaro-Moreno
Published in: Environment International, Issue 186, 2024, Page(s) 108597, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108597

In Vitro Cell Transformation Assays: A Valuable Approach for Carcinogenic Potentiality Assessment of Nanomaterials

Author(s): Nivedita Chatterjee, Ernesto Alfaro-Moreno
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 8219, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24098219

The Effects of Titanium Dioxide Nanoparticles on Osteoblasts Mineralization: A Comparison between 2D and 3D Cell Culture Models

Author(s): Gabriela de Souza Castro, Wanderson de Souza, Thais Suelen Mello Lima, Danielle Cabral Bonfim, Jacques Werckmann, Braulio Soares Archanjo, José Mauro Granjeiro, Ana Rosa Ribeiro, Sara Gemini-Piperni
Published in: Nanomaterials, Issue 13, 2025, Page(s) 425, ISSN 2079-4991
Publisher: DOAJ
DOI: 10.3390/nano13030425

Ambient black carbon particles in human ovarian tissue and follicular fluid

Author(s): Eva Bongaerts, Katariina Mamia, Ilmatar Rooda, Richelle D. Björvang, Kiriaki Papaikonomou, Sebastian B. Gidlöf, Jan I. Olofsson, Marcel Ameloot, Ernesto Alfaro-Moreno, Tim S. Nawrot, Pauliina Damdimopoulou
Published in: Environment International, Issue 179, 2024, Page(s) 108141, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108141

Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro

Author(s): Eleftheria Maria Panagiotou, Anastasios Damdimopoulos, Tianyi Li, Elisabeth Moussaud-Lamodière, Mikael Pedersen, Filipa Lebre, Karin Pettersson, Catarina Arnelo, Kiriaki Papaikonomou, Ernesto Alfaro-Moreno, Cecilia Lindskog, Terje Svingen, Pauliina Damdimopoulou
Published in: Toxicology, Issue 505, 2025, Page(s) 153815, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2024.153815

Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistant Staphylococcus aureus, immunomodulatory and osteogenic

Author(s): B. Costa, J. Coelho, V. Silva, H. Shahrour, N.A. Costa, A.R. Ribeiro, S.G. Santos, F. Costa, G. Martínez-de-Tejada, C. Monteiro, M.C.L. Martins
Published in: Acta Biomaterialia, Issue 191, 2024, Page(s) 98-112, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2024.11.016

The system of self-consistent models based on quasi-SMILES as a tool to predict the potential of nano-inhibitors of human lung carcinoma cell line A549 for different experimental conditions

Author(s): Alla P Toropova, João Meneses, Ernesto Alfaro-Moreno, Andrey A Toropov
Published in: Drug and Chemical Toxicology, Issue 04, 2023, ISSN 0148-0545
Publisher: Marcel Dekker Inc.
DOI: 10.1080/01480545.2023.2174986

Thesis and dissertations (3)

Estimation of probable environmental concentrations of released titanium dioxide nanoparticles in Mexico

Author(s): Luis Mauricio Ortiz Galvez
Published in: MAster Thesis, 2022
Publisher: University of the Basque Country (UPV/EHU)

Modulation of cellular responses mediated by extracellular vesicles mediated by nanomaterials

Author(s): Thaís Suelen Mello Lima
Published in: 2021
Publisher: National Institute of Metrology Quality and Technology

Development of a skin-on-a-chip device for toxicological evaluation of nanomaterials

Author(s): Samantha Faria da Costa Oliveira
Published in: Issue 1, 2022
Publisher: Universidade

Monographic books (1)

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Author(s): Nivedita Chatterjee, Vânia Vilas-Boas, Filipa Lebre, Ana R. Ribeiro, S. Costa, S. Nogueira, M González-Durruthy, H. Coley, N. Oliva, R. De Vecchi, E. Alfaro-Moreno
Published in: Nanosafety: A Comprehensive Approach to Assess Nanomaterial Exposure on the Environment and Health, Issue 2025, 2025, Page(s) all
Publisher: Springer Nature