Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular and hepatic diseases.

Project Information

PANACHE

Grant agreement ID: 858014

DOI

10.3030/858014

Project closed

EC signature date 16 December 2019

Start date 1 March 2020

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 503 628,75

EU contribution

€ 3 503 628,75

Coordinated by

VRIJE UNIVERSITEIT BRUSSEL
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Workshop organized in A Coruña-Spain

Workshop Pannexins and connexins in health and disease

Workshop organized in Geneva-Switzerland

Workshop Pannexins and connexins in cardiovascular pathophysiology

Workshop organized in Brussels-Belgium

"Workshop ""Pannexin-derived and connexin-derived peptidomimetics as novel therapeutic tools"""

Websites, patent fillings, videos etc. (1)

Website and logo

Evaluation of dissemination and communciation tools including website logo leaflet and social media

Publications

Peer reviewed articles (18)

Hepatic cell junctions: Pulling a double‐duty

Author(s): Raf Van Campenhout, Mathieu Vinken
Published in: Liver International, Issue 44 (11), 2024, Page(s) 2873-2889, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.16045

Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting

Author(s): Debora Iaculli, Jade Montgomery, Arthur Lamouroux, Anne Caufriez, Rafael Gozalbes, Mathieu Vinken, Filippo Molica, Brenda R. Kwak, Steven Ballet
Published in: RSC Medicinal Chemistry, 2025, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4md00850b

Pannexin1 channels in the liver: an open enemy

Author(s): Raf Van Campenhout, Anne Caufriez, Andrés Tabernilla, Amy Maerten, Sybren De Boever, Julen Sanz-Serrano, Prashant Kadam, Mathieu Vinken
Published in: Frontiers in Cell and Developmental Biology, Issue 11, 2023, Page(s) 1220405, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2023.1220405

Osteoarthritis: Mechanistic Insights, Senescence, and Novel Therapeutic Opportunities

Author(s): Paula Carpintero-Fernández, Marta Varela-Eirín, Alejandro García-Yuste, Iñaki López-Díaz, José Ramón Caeiro, María D. Mayán
Published in: Bioelectricity, Issue 4/1, 2022, Page(s) 39-47, ISSN 2576-3105
Publisher: Mary Ann Liebert, Inc.
DOI: 10.1089/bioe.2021.0039

Pannexin1 channels-a potential therapeutic target in inflammation

Author(s): Olga Martyna Rusiecka, Malaury Tournier, Filippo Molica, Brenda R. Kwak
Published in: Frontiers in Cell and Developmental Biology, Issue 2296634X, 2022, Page(s) 1020826, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2022.1020826

Effects of drugs formerly proposed for COVID-19 treatment on connexin43 hemichannels

Author(s): Axelle Cooreman, Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Kaat Leroy, Prashant Kadam, Julen Sanz Serrano, Bruna dos Santos Rodrigues, Pieter Annaert, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 23/9, 2022, Page(s) 5018, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23095018

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

Author(s): Andrés Tabernilla, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, Ana Rita Gomes, Emma Arnesdotter, Eva Gijbels, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 22/9, 2021, Page(s) 5038, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22095038

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Author(s): Milos Mihajlovic, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 23/6, 2022, Page(s) 3315, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23063315

The role of Pannexin1 channels in cardiac ischemia/reperfusion injury

Author(s): Malaury Tournier, Olga M. Rusiecka, Filippo Molica, Brenda R Kwak
Published in: Conditioning Medicine, Issue 5, 2022, Page(s) 123-130, ISSN 2577-3240
Publisher: Conditioning Medicine

Mechanisms Underlying Connexin Hemichannel Activation in Disease

Author(s): Raf Van Campenhout, Ana Rita Gomes, Timo W.M. De Groof, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 22/7, 2021, Page(s) 3503, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073503

Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence

Author(s): Paula Carpintero-Fernández, Michela Borghesan, Olga Eleftheriadou, Belen Pan-Castillo, Juan Antonio Fafián-Labora, Tom P. Mitchell, Alejandro Yuste, Muge Ogrunc, Thomas D. Nightingale, Maria Mayan, Ana O’Loghlen
Published in: Cell Death and Disease, Issue 13/2, 2022, Page(s) 163, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-04569-3

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Author(s): Marta Varela-Eirín, Paula Carpintero-Fernández, Amanda Guitián-Caamaño, Adrián Varela-Vázquez, Alejandro García-Yuste, Agustín Sánchez-Temprano, Susana B. Bravo-López, José Yañez-Cabanas, Eduardo Fonseca, Raquel Largo, Ali Mobasheri, José Ramón Caeiro, María D. Mayán
Published in: Cell Death and Disease, Issue 13/8, 2022, Page(s) 681, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-05089-w

Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals

Author(s): Vânia Vilas-Boas, Eva Gijbels, Kaat Leroy, Alanah Pieters, Audrey Baze, Céline Parmentier, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 22/20, 2021, Page(s) 11005, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222011005

Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1

Author(s): Anne Caufriez, Arthur Lamouroux, Charlotte Martin, Debora Iaculli, Elif Ince Ergüç, Rafael Gozalbes, Maria D. Mayan, Brenda R. Kwak, Andrés Tabernilla, Mathieu Vinken, Steven Ballet
Published in: Bioorganic Chemistry, Issue 138, 2023, Page(s) 106612, ISSN 0045-2068
Publisher: Academic Press
DOI: 10.1016/j.bioorg.2023.106612

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Author(s): Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Published in: Journal of Nanobiotechnology, Issue 21/1, 2023, Page(s) 371, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-023-02137-1

Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection

Author(s): Olga M. Rusiecka, Jade Montgomery, Sandrine Morel, Daniela Batista-Almeida, Raf Van Campenhout, Mathieu Vinken, Henrique Girao, Brenda R. Kwak
Published in: Biomolecules, Issue 10/9, 2020, Page(s) 1225, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10091225

Structure-based design and synthesis of stapled 10Panx1 analogues for use in cardiovascular inflammatory diseases

Author(s): Arthur Lamouroux, Malaury Tournier, Debora Iaculli, Anne Caufriez, Olga M. Rusiecka, Charlotte Martin, Viviane Bes, Laureano E. Carpio, Yana Girardin, Remy Loris, Andrés Tabernilla, Filippo Molica, Rafael Gozalbes, María D. Mayán, Mathieu Vinken, Brenda R. Kwak, Steven Ballet
Published in: Journal of Medicinal Chemistry, Issue 66/18, 2023, Page(s) 13086-13102, ISSN 1520-4804
Publisher: ACS Publications
DOI: 10.1021/acs.jmedchem.3c01116

Effects of drugs formerly suggested for COVID-19 repurposing on pannexin1 channels

Author(s): Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Axelle Cooreman, Kaat Leroy, Julen Sanz Serrano, Prashant Kadam, Bruna dos Santos Rodrigues, Arthur Lamouroux, Steven Ballet, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 23/10, 2022, Page(s) 5664, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23105664

Intellectual Property Rights

Trademark (1)

"Trademark registration of software ""PeptiDesCalculator"""

Application/Publication number: EU 019144830
Date: 2025-02-19
Applicant(s): PROTOQSAR 2000 SL

Other (1)

"Copyright protection of the software ""PeptiKinetics"""

Application/Publication number: - 09/389259.9/25
Date: 2025-02-26
Applicant(s): PROTOQSAR 2000 SL