Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular and hepatic diseases.

Informazioni relative al progetto

PANACHE

ID dell’accordo di sovvenzione: 858014

DOI

10.3030/858014

Progetto chiuso

Data della firma CE 16 Dicembre 2019

Data di avvio 1 Marzo 2020

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 3 503 628,75

Contributo UE

€ 3 503 628,75

Coordinato da

VRIJE UNIVERSITEIT BRUSSEL
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Workshop organized in A Coruña-Spain

Workshop Pannexins and connexins in health and disease

Workshop organized in Geneva-Switzerland

Workshop Pannexins and connexins in cardiovascular pathophysiology

Workshop organized in Brussels-Belgium

"Workshop ""Pannexin-derived and connexin-derived peptidomimetics as novel therapeutic tools"""

Websites, patent fillings, videos etc. (1)

Website and logo

Evaluation of dissemination and communciation tools including website logo leaflet and social media

Pubblicazioni

Peer reviewed articles (18)

Hepatic cell junctions: Pulling a double‐duty

Autori: Raf Van Campenhout, Mathieu Vinken
Pubblicato in: Liver International, Numero 44 (11), 2024, Pagina/e 2873-2889, ISSN 1478-3223
Editore: Blackwell Publishing Inc.
DOI: 10.1111/liv.16045

Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting

Autori: Debora Iaculli, Jade Montgomery, Arthur Lamouroux, Anne Caufriez, Rafael Gozalbes, Mathieu Vinken, Filippo Molica, Brenda R. Kwak, Steven Ballet
Pubblicato in: RSC Medicinal Chemistry, 2025, ISSN 2632-8682
Editore: Royal Society of Chemistry
DOI: 10.1039/d4md00850b

Pannexin1 channels in the liver: an open enemy

Autori: Raf Van Campenhout, Anne Caufriez, Andrés Tabernilla, Amy Maerten, Sybren De Boever, Julen Sanz-Serrano, Prashant Kadam, Mathieu Vinken
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 11, 2023, Pagina/e 1220405, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2023.1220405

Osteoarthritis: Mechanistic Insights, Senescence, and Novel Therapeutic Opportunities

Autori: Paula Carpintero-Fernández, Marta Varela-Eirín, Alejandro García-Yuste, Iñaki López-Díaz, José Ramón Caeiro, María D. Mayán
Pubblicato in: Bioelectricity, Numero 4/1, 2022, Pagina/e 39-47, ISSN 2576-3105
Editore: Mary Ann Liebert, Inc.
DOI: 10.1089/bioe.2021.0039

Pannexin1 channels-a potential therapeutic target in inflammation

Autori: Olga Martyna Rusiecka, Malaury Tournier, Filippo Molica, Brenda R. Kwak
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 2296634X, 2022, Pagina/e 1020826, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.1020826

Effects of drugs formerly proposed for COVID-19 treatment on connexin43 hemichannels

Autori: Axelle Cooreman, Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Kaat Leroy, Prashant Kadam, Julen Sanz Serrano, Bruna dos Santos Rodrigues, Pieter Annaert, Mathieu Vinken
Pubblicato in: International Journal of Molecular Sciences, Numero 23/9, 2022, Pagina/e 5018, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23095018

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

Autori: Andrés Tabernilla, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, Ana Rita Gomes, Emma Arnesdotter, Eva Gijbels, Mathieu Vinken
Pubblicato in: International Journal of Molecular Sciences, Numero 22/9, 2021, Pagina/e 5038, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22095038

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Autori: Milos Mihajlovic, Mathieu Vinken
Pubblicato in: International Journal of Molecular Sciences, Numero 23/6, 2022, Pagina/e 3315, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23063315

The role of Pannexin1 channels in cardiac ischemia/reperfusion injury

Autori: Malaury Tournier, Olga M. Rusiecka, Filippo Molica, Brenda R Kwak
Pubblicato in: Conditioning Medicine, Numero 5, 2022, Pagina/e 123-130, ISSN 2577-3240
Editore: Conditioning Medicine

Mechanisms Underlying Connexin Hemichannel Activation in Disease

Autori: Raf Van Campenhout, Ana Rita Gomes, Timo W.M. De Groof, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Pubblicato in: International Journal of Molecular Sciences, Numero 22/7, 2021, Pagina/e 3503, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073503

Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence

Autori: Paula Carpintero-Fernández, Michela Borghesan, Olga Eleftheriadou, Belen Pan-Castillo, Juan Antonio Fafián-Labora, Tom P. Mitchell, Alejandro Yuste, Muge Ogrunc, Thomas D. Nightingale, Maria Mayan, Ana O’Loghlen
Pubblicato in: Cell Death and Disease, Numero 13/2, 2022, Pagina/e 163, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-022-04569-3

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Autori: Marta Varela-Eirín, Paula Carpintero-Fernández, Amanda Guitián-Caamaño, Adrián Varela-Vázquez, Alejandro García-Yuste, Agustín Sánchez-Temprano, Susana B. Bravo-López, José Yañez-Cabanas, Eduardo Fonseca, Raquel Largo, Ali Mobasheri, José Ramón Caeiro, María D. Mayán
Pubblicato in: Cell Death and Disease, Numero 13/8, 2022, Pagina/e 681, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-022-05089-w

Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals

Autori: Vânia Vilas-Boas, Eva Gijbels, Kaat Leroy, Alanah Pieters, Audrey Baze, Céline Parmentier, Mathieu Vinken
Pubblicato in: International Journal of Molecular Sciences, Numero 22/20, 2021, Pagina/e 11005, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222011005

Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1

Autori: Anne Caufriez, Arthur Lamouroux, Charlotte Martin, Debora Iaculli, Elif Ince Ergüç, Rafael Gozalbes, Maria D. Mayan, Brenda R. Kwak, Andrés Tabernilla, Mathieu Vinken, Steven Ballet
Pubblicato in: Bioorganic Chemistry, Numero 138, 2023, Pagina/e 106612, ISSN 0045-2068
Editore: Academic Press
DOI: 10.1016/j.bioorg.2023.106612

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Autori: Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Pubblicato in: Journal of Nanobiotechnology, Numero 21/1, 2023, Pagina/e 371, ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-023-02137-1

Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection

Autori: Olga M. Rusiecka, Jade Montgomery, Sandrine Morel, Daniela Batista-Almeida, Raf Van Campenhout, Mathieu Vinken, Henrique Girao, Brenda R. Kwak
Pubblicato in: Biomolecules, Numero 10/9, 2020, Pagina/e 1225, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom10091225

Structure-based design and synthesis of stapled 10Panx1 analogues for use in cardiovascular inflammatory diseases

Autori: Arthur Lamouroux, Malaury Tournier, Debora Iaculli, Anne Caufriez, Olga M. Rusiecka, Charlotte Martin, Viviane Bes, Laureano E. Carpio, Yana Girardin, Remy Loris, Andrés Tabernilla, Filippo Molica, Rafael Gozalbes, María D. Mayán, Mathieu Vinken, Brenda R. Kwak, Steven Ballet
Pubblicato in: Journal of Medicinal Chemistry, Numero 66/18, 2023, Pagina/e 13086-13102, ISSN 1520-4804
Editore: ACS Publications
DOI: 10.1021/acs.jmedchem.3c01116

Effects of drugs formerly suggested for COVID-19 repurposing on pannexin1 channels

Autori: Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Axelle Cooreman, Kaat Leroy, Julen Sanz Serrano, Prashant Kadam, Bruna dos Santos Rodrigues, Arthur Lamouroux, Steven Ballet, Mathieu Vinken
Pubblicato in: International Journal of Molecular Sciences, Numero 23/10, 2022, Pagina/e 5664, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23105664

Diritti di proprietà intellettuale

Trademark (1)

"Trademark registration of software ""PeptiDesCalculator"""

Numero candidatura/pubblicazione: EU 019144830
Data: 2025-02-19
Candidato/i: PROTOQSAR 2000 SL

Other (1)

"Copyright protection of the software ""PeptiKinetics"""

Numero candidatura/pubblicazione: - 09/389259.9/25
Data: 2025-02-26
Candidato/i: PROTOQSAR 2000 SL