Project description
Safer diagnostic agents for MRI
Contrast-enhanced magnetic resonance imaging (MRI) is an important and versatile medical diagnostics technique, particularly for cancers. Warnings have been issued against Gadolinium (Gd)-based contrast agents (GBCAs), which are routinely employed during MRI diagnostic procedures, due to health concerns about Gd accumulation in the human body. The EU-funded AlternativesToGd project aims to develop metal-free hyperpolarised (HP) metabolic CAs to enable molecular imaging and monitor enzymatic conversions with very high sensitivity. A major challenge for researchers is overcoming the short lifetime of HP states in these CAs. The team will investigate three ground-breaking HP techniques to maximise HP lifetime and achieve unprecedented sensitivity in contrast-enhanced MRI diagnostics with CAs that are safe, non-toxic and completely eliminated from the body after the procedure.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
91120 Jerusalem
Israel
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Participants (9)
10124 Torino
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2800 Kongens Lyngby
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89081 Ulm
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OX1 2JD Oxford
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67450 Mundolsheim
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
80539 Munchen
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CB2 1TN Cambridge
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1010 Wien
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16163 Genova
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