Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Project Information

AlternativesToGd

Grant agreement ID: 858149

DOI 10.3030/858149

Project closed

EC signature date 24 September 2019

Start date 1 October 2019

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 065 956,25

EU contribution € 3 065 956,25

Coordinated by

HADASSAH MEDICAL ORGANIZATION
Israel

Deliverables

Documents, reports (10)

Report comparing perfusion and tissue- retention imaging with HP water vs. GBCA in a pig model of coronary artery disease

Report comparing perfusion and tissueretention imaging with HP water vs GBCA in a pig model of coronary artery disease

Report on encapsulation of new and unconventional dDNP agents
Interim progress report on 13C hyperpolarisation in ensembles of nano-diamonds
Interim progress report on the safety of nitrate intravenous injection
Report on dual tuned coils installed at partners' sites

Report on dual tuned coils installed at partners sites

Interim progress report on 13C labelled agents for PHIP-SAH
Interim progress report on the design of a 15N/1H coil operating at 1.5T and 7T

Interim progress report on the design of a 15N1H coil operating at 15T and 7T

Interim progress report on 1H relaxation times of HOD in micro-emulsions and 1H hyperpolarisation

Interim progress report on 1H relaxation times of HOD in microemulsions and 1H hyperpolarisation

Interim progress report on the design of efficient sampling strategies and motion compensation and a plan for implementation on the partners' MRI scanners
Report on polarisation transfer protocols for imaging

Open Research Data Pilot (2)

First Version of Data Management Plan
Final Data Management Plan

Websites, patent fillings, videos etc. (1)

Project Website and Corporate Identity

Other (1)

End user workshop

Publications

Peer reviewed articles (29)

Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study

Author(s): David Shaul, Naama Lev-Cohain, Gal Sapir, Jacob Sosna, J. Moshe Gomori, Leo Joskowicz, Rachel Katz-Brull
Published in: NMR in biomedicine, 2023, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4993

Mechanistic Insights of Seeded Diamond Growth from Molecular Precursors

Author(s): Christopher P. Ender; Jiaxu Liang; Jonas Friebel; Todd Zapata; Manfred Wagner; Anna Ermakova; Tanja Weil
Published in: Diamond and Related Materials, Issue Vol 122, 2022, Page(s) 108796, ISSN 0925-9635
Publisher: Elsevier BV
DOI: 10.1016/j.diamond.2021.108796

Hyperpolarized Carbon-13 MRI in Breast Cancer

Author(s): Ramona Woitek, Kevin M. Brindle
Published in: Diagnostics, 2023, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics13132311

Accumulation of 3-aminopropylphosphonate in the ex vivo brain observed by phosphorus-31 nuclear magnetic resonance

Author(s): David Shaul, Benjamin Grieb, Naama Lev-Cohain, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Published in: NMR in Biomedicine, 2022, Page(s) e4721, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4721

ParaHydrogen Polarized Ethyl-[1-13 C]pyruvate in Water, a Key Substrate for Fostering the PHIP-SAH Approach to Metabolic Imaging.

Author(s): Carla Carrera; Eleonora Cavallari; Giuseppe Digilio; Oksana Bondar; Silvio Aime; Francesca Reineri
Published in: Chemphyschem, Issue Vol 22, Iss 11, 2021, Page(s) 1042-1048, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202100062

Genetic algorithm‐based optimization of pulse sequences

Author(s): Vencel Somai; Felix Kreis; Adam Gaunt; Anastasia Tsyben; Ming Li Chia; Friederike Hesse; Alan J. Wright; Kevin M. Brindle
Published in: Magnetic Resonance in Medicine, Issue Vol 87, Iss 5, 2022, Page(s) 2130–2144, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29110

Germanium iodide mediated synthesis of nanodiamonds from adamantane “seeds” under moderate high-pressure high-temperature conditions

Author(s): Jiaxu Liang, Christopher P. Ender, Todd Zapata, Anna Ermakova, Manfred Wagner, Tanja Weil
Published in: Diamond and Related Materials, Issue 108, 2020, Page(s) 108000, ISSN 0925-9635
Publisher: Elsevier BV
DOI: 10.1016/j.diamond.2020.108000

Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization

Author(s): Catriona H. E. Rooney, Dr. Ayelet Gamliel, David Shaul, Prof. Damian J. Tyler, Dr. James T. Grist, Prof. Rachel Katz-Brull
Published in: ChemPhysChem, 2023, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202300144

RF coil design for accurate parallel imaging on 13C MRSI using 23Na sensitivity profiles

Author(s): Juan D. Sanchez-Heredia, Rie B. Olin, James T. Grist, Wenjun Wang, Nikolaj Bøgh, Vitaliy Zhurbenko, Esben S. Hansen, Rolf F. Schulte, Damian Tyler, Christoffer Laustsen, Jan H. Ardenkjær-Larsen
Published in: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29259

Hydrogenative-PHIP polarized metabolites for biological studies

Author(s): Francesca Reineri, Eleonora Cavallari, Carla Carrera, Silvio Aime
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue Vol 34, Iss 1, 2021, Page(s) 25-47, ISSN 1352-8661
Publisher: Springer Nature
DOI: 10.1007/s10334-020-00904-x

Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration

Author(s): Rachel Katz-Brull
Published in: Biology, Issue 11-5, 2022, Page(s) 794, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology11050794

Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

Author(s): Yingke Wu, Md Noor A Alam, Priyadharshini Balasubramanian, Pia Winterwerber, Anna Ermakova, Michael Müller, Manfred Wagner, Fedor Jelezko, Marco Raabe, Tanja Weil
Published in: Advanced NanoBiomed Research, Issue Vol 1, Iss 7, 2021, Page(s) 2000101, ISSN 2699-9307
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anbr.202000101

Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1-13C]pyruvate

Author(s): O.Bondar, E.Cavallari, C.Carrera, S.Aime, F.Reineri
Published in: Catalysis Today, 2021, ISSN 0920-5861
Publisher: Elsevier BV
DOI: 10.1016/j.cattod.2021.11.030

Design and Analysis of Field-of-View Independent k-Space Trajectories for Magnetic Resonance Imaging

Author(s): Tobias Speidel, Patrick Metze, Kilian Stumpf, Thomas Hüfken, Volker Rasche
Published in: Sec. Medical Physics and Imaging, 2022, ISSN 2296-424X
Publisher: Frontiers
DOI: 10.3389/fphy.2022.867676

Hyperpolarized 13 C magnetic resonance imaging for noninvasive assessment of tissue inflammation.

Author(s): Stephanie Anderson; James T. Grist; James T. Grist; Andrew Lewis; Damian J. Tyler
Published in: Nmr in Biomedicine, Issue 3, 2021, Page(s) e4460, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4460

Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism**

Author(s): Dr. J. Eills, Dr. E. Cavallari, R. Kircher, G. Di Matteo, Dr. C. Carrera, Dr. L. Dagys, Prof. M. H. Levitt, K. L. Ivanov, Prof. S. Aime, Dr. F. Reineri, Dr. K. Münnemann, Prof. D. Budker, Prof. G. Buntkowsky, Dr. S. Knecht
Published in: Angewandte Chemie, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014933

Design and Testing of Diagnostic MRI/MRS Applications Based On Signal Enhancement by Parahydrogen-Induced Polarization

Author(s): Francesca Reineri
Published in: Analysis & Sensing, 2022, ISSN 2629-2742
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anse.202200028

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.

Author(s): Stephan Knecht; John W. Blanchard; Danila A. Barskiy; Eleonora Cavallari; Laurynas Dagys; Erik van Dyke; Maksim Tsukanov; Bea Bliemel; Kerstin Münnemann; Silvio Aime; Francesca Reineri; Malcolm H. Levitt; Gerd Buntkowsky; Alexander Pines; Peter Blümler; Dmitry Budker; James Eills
Published in: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13, Issue 9, 2021, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.15120/gsi-2021-01203

Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques

Author(s): Andreas B. Schmidt, C. Russell Bowers, Kai Buckenmaier, Eduard Y. Chekmenev, Henri de Maissin, James Eills, Frowin Ellermann, Stefan Glöggler, Jeremy W. Gordon, Stephan Knecht, Igor V. Koptyug, Jule Kuhn, Andrey N. Pravdivtsev, Francesca Reineri, Thomas Theis, Kolja Them, and Jan-Bernd Hövener
Published in: Analytical Chemistry, Issue Vol 94, Iss 1, 2022, Page(s) 479-502, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c04863

Laser-Synthesis of NV-Centers-Enriched Nanodiamonds: Effect of Different Nitrogen Sources

Author(s): Luca Basso, Mirko Sacco, Nicola Bazzanella, Massimo Cazzanelli, Alessandro Barge, Michele Orlandi, Angelo Bifone, Antonio Miotello
Published in: Micromachines, Issue 11/6, 2020, Page(s) 579, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060579

Increasing the sensitivity of hyperpolarized [ 15 N 2 ]urea detection by serial transfer of polarization to spin‐coupled protons

Author(s): Felix Kreis, Alan J. Wright, Vencel Somai, Rachel Katz‐Brull, Kevin M. Brindle
Published in: Magnetic Resonance in Medicine, Issue 84/4, 2020, Page(s) 1844-1856, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28241

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

Author(s): Arthur C. Pinon, Andrea Capozzi, Jan Henrik Ardenkjær-Larsen
Published in: Communications Chemistry, Issue 3/1, 2020, ISSN 2399-3669
Publisher: Springer Nature Limited
DOI: 10.1038/s42004-020-0301-6

Signal enhancement of hyperpolarized 15N sites in solution—increase in solid-state polarization at 3.35 T and prolongation of relaxation in deuterated water mixtures

Author(s): Ayelet Gamliel, David Shaul, J. Moshe Gomori, Rachel Katz-Brull
Published in: NMR in biomedicine, 2022, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4787

Advances in Stabilization and Enrichment of Shallow Nitrogen-Vacancy Centers in Diamond for Biosensing and Spin-Polarization Transfer

Author(s): Federico Gorrini, Angelo Bifone
Published in: Biosensors, 2023, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios13070691

Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging

Author(s): James T. Grist, Nikolaj Bøgh, Esben Søvsø Hansen, Anna M. Schneider, Richard Healicon, Vicky Ball, Jack J. J. J. Miller, Sean Smart, Yvonne Couch, Alastair M. Buchan, Damian J. Tyler & Christoffer Laustsen
Published in: Nature Scientific Reports, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-28643-8

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain

Author(s): Richard Healicon, Catriona H. E. Rooney, Vicky Ball, Ayaka Shinozaki, Jack J. Miller, Sean Smart, Daniel Radford-Smith, Daniel Anthony, Damian J. Tyler, James T. Grist
Published in: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29274

Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing.

Author(s): Yingke Wu; Noor A Alam; Noor A Alam; Priyadharshini Balasubramanian; Anna Ermakova; Anna Ermakova; Stephan Fischer; Holger Barth; Manfred Wagner; Marco Raabe; Marco Raabe; Fedor Jelezko; Tanja Weil; Tanja Weil
Published in: Nano Letters, Issue Vol 21, Iss 9, 2021, Page(s) 3780-3788, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00043

Long-Lived Ensembles of Shallow NV- Centers in Flat and Nanostructured Diamonds by Photoconversion.

Author(s): Federico Gorrini; Federico Gorrini; C. Dorigoni; Domingo Olivares-Postigo; Domingo Olivares-Postigo; Rakshyakar Giri; Pietro Aprà; Federico Picollo; Angelo Bifone; Angelo Bifone
Published in: ACS Applied Materials & Interfaces, Issue Vol 13, Iss 36, 2021, Page(s) 43221-43232, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c09825

Metabolic imaging with deuterium labeled substrates

Author(s): Jacob Chen Ming Low, Alan J Wright, Friederike Hesse, Jianbo Cao, Kevin M Brindle
Published in: Progress in Nuclear Magnetic Resonance Spectroscopy, 2023, ISSN 0079-6565
Publisher: Elsevier BV
DOI: 10.1016/j.pnmrs.2023.02.002

Other (2)

Photoconversion of shallow nitrogen-vacancy centers in flat and nanostructured diamond under high-power laser irradiation

Author(s): Federico Gorrini, Carla Dorigoni, Domingo Olivares-Postigo, Rakshyakar Giri, Pietro Aprà, Federico Picollo, Angelo Bifone
Published in: 2021
Publisher: arXiv
DOI: 10.48550/arxiv.2105.04939

Divergent effects of laser irradiation on ensembles of nitrogen-vacancy centers in bulk and nano-diamonds: implications for biosensing

Author(s): Domingo Olivares-Postigo, Federico Gorrini, Valeria Bitonto, Johannes Ackermann, Rakshyakar Giri, Anke Krueger, Angelo Bifone
Published in: 2021
Publisher: arXiv
DOI: 10.48550/arxiv.2110.02955

Non-peer reviewed articles (2)

Metabolic Reactions Studied by Zero- and Low-Field Nuclear Magnetic Resonance

Author(s): James Eills, Román Picazo-Frutos, Oksana Bondar, Eleonora Cavallari, Carla Carrera, Sylwia J. Barker, Marcel Utz, Silvio Aime, Francesca Reineri, Dmitry Budker, John W. Blanchard
Published in: arXiv, 2022, ISSN 2331-8422
Publisher: arXiv
DOI: 10.48550/arxiv.2205.12380

High Pressure Induced Formation of Carbon Nanorods from Tetracosane

Author(s): Jiaxu Liang, Christopher P. Ender, Pascal Rohrbeck, Robert Graf, Ingo Lieberwirth, Manfred Wagner, Stefan A. L. Weber, Klaus Müllen and Tanja Weil
Published in: ChemRxiv: Nanoscience, 2022, ISSN 2573-2293
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2022-2g6dl

Intellectual Property Rights

Other (1)

SYSTEM AND METHOD FOR ACQUISITION OF A MAGNETIC RESONANCE IMAGE AS WELL AS DEVICE FOR DETERMINING A TRAJECTORY FOR ACQUISITION OF A MAGNETIC RESONANCE IMAGE

Application/Publication number: WO 2022184808A1
Date: 2022-08-05
Applicant(s): UNIVERSITAET ULM