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Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Deliverables

Report on encapsulation of new and unconventional dDNP agents

Report on encapsulation of new and unconventional dDNP agents

Interim progress report on 13C hyperpolarisation in ensembles of nano-diamonds

Interim progress report on 13C hyperpolarisation in ensembles of nano-diamonds

Interim progress report on the safety of nitrate intravenous injection

Interim progress report on the safety of nitrate intravenous injection

Report on dual tuned coils installed at partners' sites

Report on dual tuned coils installed at partners sites

Interim progress report on 13C labelled agents for PHIP-SAH

Interim progress report on 13C labelled agents for PHIP-SAH

Interim progress report on the design of a 15N/1H coil operating at 1.5T and 7T

Interim progress report on the design of a 15N1H coil operating at 15T and 7T

Interim progress report on 1H relaxation times of HOD in micro-emulsions and 1H hyperpolarisation

Interim progress report on 1H relaxation times of HOD in microemulsions and 1H hyperpolarisation

Interim progress report on the design of efficient sampling strategies and motion compensation and a plan for implementation on the partners' MRI scanners

Interim progress report on the design of efficient sampling strategies and motion compensation and a plan for implementation on the partners' MRI scanners

Report on polarisation transfer protocols for imaging

Report on polarisation transfer protocols for imaging

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Publications

Mechanistic Insights of Seeded Diamond Growth from Molecular Precursors

Author(s): Christopher P. Ender; Jiaxu Liang; Jonas Friebel; Todd Zapata; Manfred Wagner; Anna Ermakova; Tanja Weil
Published in: Diamond and Related Materials, Vol 122, 2022, Page(s) 108796, ISSN 0925-9635
Publisher: Elsevier BV
DOI: 10.1016/j.diamond.2021.108796

Accumulation of 3-aminopropylphosphonate in the ex vivo brain observed by phosphorus-31 nuclear magnetic resonance

Author(s): David Shaul, Benjamin Grieb, Naama Lev-Cohain, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Published in: NMR in Biomedicine, 2022, Page(s) e4721, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4721

ParaHydrogen Polarized Ethyl-[1-13 C]pyruvate in Water, a Key Substrate for Fostering the PHIP-SAH Approach to Metabolic Imaging.

Author(s): Carla Carrera; Eleonora Cavallari; Giuseppe Digilio; Oksana Bondar; Silvio Aime; Francesca Reineri
Published in: Chemphyschem, Vol 22, Iss 11, 2021, Page(s) 1042-1048, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202100062

Genetic algorithm‐based optimization of pulse sequences

Author(s): Vencel Somai; Felix Kreis; Adam Gaunt; Anastasia Tsyben; Ming Li Chia; Friederike Hesse; Alan J. Wright; Kevin M. Brindle
Published in: Magnetic Resonance in Medicine, Vol 87, Iss 5, 2022, Page(s) 2130–2144, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29110

Germanium iodide mediated synthesis of nanodiamonds from adamantane “seeds” under moderate high-pressure high-temperature conditions

Author(s): Jiaxu Liang, Christopher P. Ender, Todd Zapata, Anna Ermakova, Manfred Wagner, Tanja Weil
Published in: Diamond and Related Materials, 108, 2020, Page(s) 108000, ISSN 0925-9635
Publisher: Elsevier BV
DOI: 10.1016/j.diamond.2020.108000

Hydrogenative-PHIP polarized metabolites for biological studies

Author(s): Francesca Reineri, Eleonora Cavallari, Carla Carrera, Silvio Aime
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Vol 34, Iss 1, 2021, Page(s) 25-47, ISSN 1352-8661
Publisher: Springer Nature
DOI: 10.1007/s10334-020-00904-x

Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration

Author(s): Rachel Katz-Brull
Published in: Biology, 11-5, 2022, Page(s) 794, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology11050794

Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

Author(s): Yingke Wu, Md Noor A Alam, Priyadharshini Balasubramanian, Pia Winterwerber, Anna Ermakova, Michael Müller, Manfred Wagner, Fedor Jelezko, Marco Raabe, Tanja Weil
Published in: Advanced NanoBiomed Research, Vol 1, Iss 7, 2021, Page(s) 2000101, ISSN 2699-9307
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anbr.202000101

Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1-13C]pyruvate

Author(s): O.Bondar, E.Cavallari, C.Carrera, S.Aime, F.Reineri
Published in: Catalysis Today, 2021, ISSN 0920-5861
Publisher: Elsevier BV
DOI: 10.1016/j.cattod.2021.11.030

Hyperpolarized 13 C magnetic resonance imaging for noninvasive assessment of tissue inflammation.

Author(s): Stephanie Anderson; James T. Grist; James T. Grist; Andrew Lewis; Damian J. Tyler
Published in: Nmr in Biomedicine, 3, 2021, Page(s) e4460, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4460

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.

Author(s): Stephan Knecht; John W. Blanchard; Danila A. Barskiy; Eleonora Cavallari; Laurynas Dagys; Erik van Dyke; Maksim Tsukanov; Bea Bliemel; Kerstin Münnemann; Silvio Aime; Francesca Reineri; Malcolm H. Levitt; Gerd Buntkowsky; Alexander Pines; Peter Blümler; Dmitry Budker; James Eills
Published in: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13, 9, 2021, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.15120/gsi-2021-01203

Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques

Author(s): Andreas B. Schmidt, C. Russell Bowers, Kai Buckenmaier, Eduard Y. Chekmenev, Henri de Maissin, James Eills, Frowin Ellermann, Stefan Glöggler, Jeremy W. Gordon, Stephan Knecht, Igor V. Koptyug, Jule Kuhn, Andrey N. Pravdivtsev, Francesca Reineri, Thomas Theis, Kolja Them, and Jan-Bernd Hövener
Published in: Analytical Chemistry, Vol 94, Iss 1, 2022, Page(s) 479-502, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c04863

Laser-Synthesis of NV-Centers-Enriched Nanodiamonds: Effect of Different Nitrogen Sources

Author(s): Luca Basso, Mirko Sacco, Nicola Bazzanella, Massimo Cazzanelli, Alessandro Barge, Michele Orlandi, Angelo Bifone, Antonio Miotello
Published in: Micromachines, 11/6, 2020, Page(s) 579, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060579

Increasing the sensitivity of hyperpolarized [ 15 N 2 ]urea detection by serial transfer of polarization to spin‐coupled protons

Author(s): Felix Kreis, Alan J. Wright, Vencel Somai, Rachel Katz‐Brull, Kevin M. Brindle
Published in: Magnetic Resonance in Medicine, 84/4, 2020, Page(s) 1844-1856, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28241

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

Author(s): Arthur C. Pinon, Andrea Capozzi, Jan Henrik Ardenkjær-Larsen
Published in: Communications Chemistry, 3/1, 2020, ISSN 2399-3669
Publisher: Springer Nature Limited
DOI: 10.1038/s42004-020-0301-6

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain

Author(s): Richard Healicon, Catriona H. E. Rooney, Vicky Ball, Ayaka Shinozaki, Jack J. Miller, Sean Smart, Daniel Radford-Smith, Daniel Anthony, Damian J. Tyler, James T. Grist
Published in: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29274

Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing.

Author(s): Yingke Wu; Noor A Alam; Noor A Alam; Priyadharshini Balasubramanian; Anna Ermakova; Anna Ermakova; Stephan Fischer; Holger Barth; Manfred Wagner; Marco Raabe; Marco Raabe; Fedor Jelezko; Tanja Weil; Tanja Weil
Published in: Nano Letters, Vol 21, Iss 9, 2021, Page(s) 3780-3788, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00043

Long-Lived Ensembles of Shallow NV- Centers in Flat and Nanostructured Diamonds by Photoconversion.

Author(s): Federico Gorrini; Federico Gorrini; C. Dorigoni; Domingo Olivares-Postigo; Domingo Olivares-Postigo; Rakshyakar Giri; Pietro Aprà; Federico Picollo; Angelo Bifone; Angelo Bifone
Published in: ACS Applied Materials & Interfaces, Vol 13, Iss 36, 2021, Page(s) 43221-43232, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c09825

Divergent effects of laser irradiation on ensembles of nitrogen-vacancy centers in bulk and nano-diamonds: implications for biosensing

Author(s): Domingo Olivares-Postigo, Federico Gorrini, Valeria Bitonto, Johannes Ackermann, Rakshyakar Giri, Anke Krueger, Angelo Bifone
Published in: 2021
Publisher: arXiv
DOI: 10.48550/arxiv.2110.02955

Rapid Hyperpolarization and Purification of the Metabolite Fumarate in Aqueous Solution

Author(s): Stephan Knecht, John W. Blanchard, Danila Barskiy, Eleonora Cavallari, Laurynas Dagys, Erik van Dyke, Maksim Tsukanov, Bea Bliemel, Kerstin Münnemann, Silvio Aime, Francesca Reineri, Malcolm H. Levitt, Gerd Buntkowsky, Alexander Pines, Peter Blümler, Dmitry Budker, James Eills
Published in: chemRxiv, 2020
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv.12909989.v1

High Pressure Induced Formation of Carbon Nanorods from Tetracosane

Author(s): Jiaxu Liang, Christopher P. Ender, Pascal Rohrbeck, Robert Graf, Ingo Lieberwirth, Manfred Wagner, Stefan A. L. Weber, Klaus Müllen and Tanja Weil
Published in: ChemRxiv: Nanoscience, 2022, ISSN 2573-2293
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2022-2g6dl