Project description
Next-generation protein-drug conjugates for cancer therapy
Antibody-drug conjugates (ADCs) represent the fast-growing class of cancer therapeutics. They consist of a highly potent cytotoxic drug linked to an antibody that is specifically targeting certain tumour markers. By combining the cytotoxicity of the drug and the targeting properties of the antibody, ADCs selectively kill cancer cells. The EU-funded TACT project is an innovative, international, multidisciplinary training and research programme designed to train 11 early-stage researchers in the field of anti-cancer therapeutics, creating a new generation of experts. Specifically, the TACT research programme will focus on key principles of the development of a new and more potent generation of protein-drug conjugates employing site-specific bioconjugation methods, environment-specific cleavable linkers, more efficient protein-based targeting systems and new analytical tools for protein characterisation.
Objective
Antibody-Drug Conjugates (ADCs) are fast growing classes of oncology therapeutics. They consist in a highly potent
cytotoxic drug connected via a linker to an antibody that is specifically targeting certain tumor markers. By combining the
cytotoxicity of the drug and the targeting properties of the antibody, ADCs kill cancer cells whilst leaving the healthy cells
unaffected, a marked improvement compared to classical chemotherapies. However, limitations still exist which could fuel
the development of new generations of ADCs with improved therapeutical properties. Targeted Anti-Cancer Therapies
(TACT) is an innovative, international, multidisciplinary training and research programme which thus aims to train 11 Early-
Stage Researchers (ESRs) on the development of state-of-the-art anti-cancer therapeutics and equip them with transferable,
future career-enhancing skills to create the next generation of experts in Europe. More specifically, TACT’s research
programme will focus on key priorities for the conception of new and more potent generations of Protein-Drug Conjugates
(PDCs): site-specific bioconjugation methods, more potent payloads, environment-specific cleavable linkers, more efficient
protein-based targeting systems and new analytical tools for acute characterization. This will be achieved by exposing the
ESRs to the leading intersectoral research scientists and laboratories in Europe who are active in this field. In doing so,
TACT combines state-of-the-art research with excellent training in PDCs, one of the hot topics in cancer and targeted
therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-ITN-2019
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
67081 Strasbourg
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.