Untangling the role of DNA helicases in human disease may lead to new therapies
Nearly one hundred years after the DNA was first identified in the 1860s, Watson and Crick concluded in 1953 that the DNA molecule exists as a 3D double-stranded helix. We now know that DNA helicases (DNA unwinding enzymes) play a fundamental role in replication, unzipping the two DNA strands to be copied. Given their conservation in numerous cell types including bacteria, viruses and eukaryotes, DNA helicases are important targets for novel drugs. However, much remains to be learned about their structures, functions and mechanisms of action. AntiHelix is training a new generation of scientists to shed light on the roles of DNA helicases in human diseases to develop highly-specific inhibitors as novel therapeutic drugs.
Fields of science
Call for proposal
See other projects for this call
Funding SchemeMSCA-ITN-ETN - European Training Networks
1059 CH Amsterdam