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DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Project description

Untangling the role of DNA helicases in human disease may lead to new therapies

Nearly one hundred years after the DNA was first identified in the 1860s, Watson and Crick concluded in 1953 that the DNA molecule exists as a 3D double-stranded helix. We now know that DNA helicases (DNA unwinding enzymes) play a fundamental role in replication, unzipping the two DNA strands to be copied. Given their conservation in numerous cell types including bacteria, viruses and eukaryotes, DNA helicases are important targets for novel drugs. However, much remains to be learned about their structures, functions and mechanisms of action. AntiHelix is training a new generation of scientists to shed light on the roles of DNA helicases in human diseases to develop highly-specific inhibitors as novel therapeutic drugs.

Call for proposal

H2020-MSCA-ITN-2019
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 522 999,36

Participants (8)

ELETTRA - SINCROTRONE TRIESTE SCPA
Italy
EU contribution
€ 522 999,36
Address
Ss 14 Km 163.5 Area Science Park
34149 Basovizza Trieste
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 595 044
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 265 619,88
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 303 172,56
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 252 788,40
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
LEAD DISCOVERY CENTER GMBH
Germany
EU contribution
€ 505 576,80
Address
Otto Hahn Strasse 15
44227 Dortmund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EDELRIS SAS
France
EU contribution
€ 274 802,04
Address
Avenue Rockefeller 60
69008 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUMICKS BV
Netherlands
EU contribution
€ 265 619,88
Address
Pilotenstraat 41
1059 CH Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)