COmplement Regulation and Variations in Opportunistic infectionS

Informations projet

CORVOS

N° de convention de subvention: 860044

DOI

10.3030/860044

Projet clôturé

Date de signature de la CE 4 Septembre 2019

Date de début 1 Decembre 2019

Date de fin 31 Janvier 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 4 088 951,28

Contribution de l’UE

€ 4 088 951,28

Coordonné par

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

CORVOS homepage (D6.4)

Established homepage with constant announcements

Documents, reports (20)

Media report on interaction with pupils (D6.7)

Media report on Trial day for school classes (+hands-on experimentation) & talk of ESR, to the secondment (disclosing her/his cultural background & motivations) [also M24,M36]

"Media report on ""Young CORVOS day"" (D6.8)"

Media report on “Young CORVOS day” -participation at “Girls in science day” (to attract girls as future scientists) [also M24,M36]

Report on mode of complement evasion by Klebsiella pneumoniae (D2.8)

Report on mode of complement evasion by Klebsiella pneumoniae (by ESR NL1)

Report on genomic sequencing of terminal complement component genes (D3.7)

Final report on genomic sequencing algorithm for the determination of mutations in terminal complement component genes (by ESR FR1)

Official insertion of an EC-PhD (D8.1)

Official insertion of an EC-PhD by the ECN

Summary of C5aR2 interactions with lectin pathway (D1.4)

Summary of C5aR2 interactions with the lectin pathway (by ESR DK1)

Summary of universities awarding a joint or a double European PhD (D8.4)

Summary of universities awarding a Joint and those awarding a Double European PhD

Press releases and interviews (D6.3)

Press releases interviews and overview articles in local newspapers and new social media also M10M22M35M46

Report on factor H-related proteins as promoters of complement attack (D2.10)

Report on whether factor H-related proteins are potent boosters for promoting complement attack against microbes (by ESR FI2)

Protocol for development of a commercial C3bc ELISA (D4.4)

Basic protocol for development of a commercial C3bc ELISA based on mAb bH6 at SVAR (by ESR NO2)

Report on evasion molecules for vaccine opportunities against pneumococci & plasmodia (D4.5)

Report on the role of FH binding- and other evasion molecules for vaccine opportunities against pneumococci and plasmodia (by ESR FI1)

"Media report ""Two wings of CORVOS"" (D6.6)"

Media report on booth “Academia & Industry” at “Long night of research” with the title “Two wings of CORVOS” whenever such annual events are held [also M24,M36]

Catalogue of gram-negative bacteria molecules regulating complement (D2.9)

Catalogue of gram-negative bacteria molecules regulating complement in opportunistic infection (by ESR SE1)

Presentation at Complement congress (D6.9)

Poster or Oral presentation at C congress also M34

List of DC functions modulated by HIV & M. tuberculosis (D2.6)

List of DC functions modulated upon the HIV-1 opsonization pattern (protection or hazard) and co-infection with M. tuberculosis (by ESR AT2)

Submission of manuscripts (D6.10)

Submission of manuscripts to peer-reviewed journals [also M41,M47]

Report on role of lectin pathway in porcine Candida sepsis (D4.6)

Report on the role of the lectin pathway in porcine Candida sepsis – assessment whether inhibition sufficient to block downstream complement activation at DK (by ESR NO1)

Report of pathways involved in mycobacterial infection (D2.7)

Report of pathways involved in mycobacterial infection (by ESR DE2)

CORVOS-MSC alumni network (D6.12)

CORVOS-Marie Skłodowska-Curie alumni network established

Award of double degrees (D7.13)

Award of Double Degrees

Data sets, microdata, etc (1)

Map of the binding sites of the PTX3 interacting molecules (D1.5)

Map of the binding sites of the PTX3 interacting molecules (by ESR IT1)

Publications

Peer reviewed articles (25)

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.

Auteurs: Hurler L, Toonen EJM, Kajdácsi E, van Bree B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Sinkovits G, Cervenak L, Würzner R, Prohászka Z
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.1039765

Clinical Relevance of Anti-C3 and Anti-C4 Autoantibodies in Lupus Nephritis

Auteurs: Vasil Vasilev, Mikel Rezola Artero , Marijana Petkova, Galya Mihaylova, Marie-Agnes Dragon-Durey , Maria Radanova, Lubka T. Roumenina
Publié dans: Kidney International Reports, 2024, ISSN 2468-0249
Éditeur: Elsevier
DOI: 10.1016/j.ekir.2024.01.052

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing

Auteurs: van der Lans SPA, Janet-Maitre M, Masson FM, Walker KA, Doorduijn DJ, Janssen AB, van Schaik W, Attrée I, Rooijakkers SHM, Bardoel BW
Publié dans: Scientific Report, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-39613-5

Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children

Auteurs: Sinkovits G, Schnur J, Hurler L, Kiszel P, Prohászka ZZ, Sík P, Kajdácsi E, Cervenak L, Maráczi V, Dávid M, Zsigmond B, Rimanóczy É, Bereczki C, Willems L, Toonen EJM, Prohászka Z
Publié dans: Scientific Reports, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-23806-5

Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections

Auteurs: Silke Huber - Mariam Massri - Marco Grasse -Verena Fleischer - Sára Kellnerová - Verena Harpf - Ludwig Knabl - Ludwig Knabl, Sr. - Tatjana Heiner - Moritz Kummann - Magdalena Neurauter - Günter Rambach - Cornelia Speth - Reinhard Würzner
Publié dans: Viruses, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13122376

Complement C7 and clusterin form a complex in circulation

Auteurs: Massri M, Toonen EJM, Sarg B, Kremser L, Grasse M, Fleischer V, Torres-Quesada O, Hengst L, Skjoedt MO, Bayarri-Olmos R, Rosbjerg A, Garred P, Orth-Höller D, Prohászka Z, Würzner R
Publié dans: Front Immunol, 2024, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2024.1330095

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

Auteurs: Hurler L, Szilágyi Á, Mescia F, Bergamaschi L, Mező B, Sinkovits G, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Würzner R; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITII
Publié dans: Frontiers in Immunology, 2023, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1162171

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System

Auteurs: Magda M, Bettoni S, Laabei M, Fairley D, Russo TA, Riesbeck K, Blom AM
Publié dans: Frontiers in Immunology, Numéro 16643224, 2022, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2022.814193

The inflammatory response induced by Aspergillus fumigatus conidia is dependent on complement activation - Insight from a whole blood model

Auteurs: Fageräng B, Götz MP, Cyranka L, Lau C, Nilsson PH, Mollnes TE, Garred P.
Publié dans: Journal of Innate Immunity, 2024, ISSN 1662-811X
Éditeur: Karger AG
DOI: 10.1159/000539368

Usefulness and analytical performances of complement multiplex assay for measuring complement biomarkers in plasma

Auteurs: Meuleman MS, Duval A, Grunenwald A, Rezola Artero M, Dermani M, Peliconi J, Revel M, Vieira-Martins P, Courbebaisse M, Parfait B, Lebeaux D, Friedlander G, Roumenina L, Chauvet S, Frémeaux-Bacchi V, Dragon-Durey MA
Publié dans: Clin Chim Acta, 2024, ISSN 0009-8981
Éditeur: Elsevier BV
DOI: 10.1016/j.cca.2023.117750

Complement-pentraxins synergy: Navigating the immune battlefield and beyond

Auteurs: Ma YJ, Parente R, Zhong H, Sun Y, Garlanda C, Doni A
Publié dans: Biomed Pharmacother, 2023, ISSN 1950-6007
Éditeur: Elsevier
DOI: 10.1016/j.biopha.2023.115878

Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa

Auteurs: Manon Janet-Maitre 1, Stéphane Pont 1, Frerich M Masson 2, Serena Sleiman 1, Julian Trouillon 1, Mylène Robert-Genthon 1, Benoît Gallet 3, Chantal Dumestre-Perard 4 5, Sylvie Elsen 1, Christine Moriscot 3, Bart W Bardoel 2, Suzan H M Rooijakkers 2, François Cretin 1, Ina Attrée 1
Publié dans: Plos Pathogens, 2023, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1011023

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

Auteurs: Cyranka L, Mariegaard I, Skjødt MO, Bayarri-Olmos R, Mollnes TE, Garred P, Rosbjerg A
Publié dans: J Innate Immun, 2023, ISSN 1662-811X
Éditeur: Karger AG
DOI: 10.1159/000535084

Associations between the von Willebrand Factor-ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality

Auteurs: Sinkovits G, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Mező B, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z
Publié dans: Thrombosis and Haemostasis, Numéro 03406245, 2022, ISSN 0340-6245
Éditeur: Schattauer
DOI: 10.1055/s-0041-1740182

Humoral complementomics - exploration of noninvasive complement biomarkers as predictors of renal cancer progression

Auteurs: Revel M, Rezola Artero M, Hamidi H, Grunenwald A, Blasco L, Vano YA, Marie Oudard S, Sanchez-Salas R, Macek P, Rodriguez Sanchez L, Cathelineau X, Vedié B, Sautes-Fridman C, Herman Fridman W, Roumenina LT, Dragon-Durey MA
Publié dans: Oncoimmunology, 2024, ISSN 2162-4011
Éditeur: Landes Bioscience
DOI: 10.1080/2162402x.2024.2328433

Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus – When Incubated in Human Whole Blood

Auteurs: Medeiros, Pedro Miguel Coelho - Schjalm, Camilla - Christiansen, Dorte - Sokolova, Marina - Pischke, Soeren Erik - Würzner, Reinhard - Mollnes, Tom Eirik - Barratt-Due, Andreas
Publié dans: Shock, 2021, ISSN 1540-0514
Éditeur: Lippincott Williams & Wilkins
DOI: 10.1097/shk.0000000000001834

HIV-1 Trans Infection via TNTs Is Impeded by Targeting C5aR

Auteurs: Bertacchi G, Posch W, Wilflingseder D
Publié dans: Biomolecules, Numéro 2218273X, 2022, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom12020313

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Auteurs: György Sinkovits - Blanka Mező - Marienn Réti - Veronika Müller - Zsolt Iványi - János Gál - László Gopcsa - Péter Reményi - Beáta Szathmáry - Botond Lakatos - János Szlávik - Ilona Bobek - Zita Z Prohászka - Zsolt Förhécz - Dorottya Csuka - Lisa Hurler - Erika Kajdácsi - László Cervenak - Petra Kiszel - Tamás Masszi - István Vályi-Nagy - Zoltán Prohászka
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2021.663187

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Auteurs: Khattab A, Rezola M, Barroso M, Kyrklund M, Pihlajamaa T, Freitag TL, van Gemert G-J, Bousema T, Permi P, Turunen O, Sauerwein R, Luty AJF and Meri S
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.1051161

C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia

Auteurs: Posch W, Vosper J, Noureen A, Zaderer V, Witting C, Bertacchi G, Gstir R, Filipek PA, Bonn GK, Huber LA, Bellmann-Weiler R, Lass-Flörl C, Wilflingseder D
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 00916749, 2021, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2021.03.038

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19

Auteurs: Götz MP, Skjoedt MO, Bayarri-Olmos R, Hansen CB, Pérez-Alós L, Jarlhelt I, Benfield T, Rosbjerg A, Garred P
Publié dans: Journal of Innate Immunity, Numéro 16628128, 2022, ISSN 1662-8128
Éditeur: Karger
DOI: 10.1159/000525508

Comprehensive Update and Revision of Nomenclature on Complement C6 and C7 Variants

Auteurs: Massri M, Foco L, Würzner R
Publié dans: Journal of Immunology, Numéro 00221767, 2022, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.2200045

Transient Binding Dynamics of Complement System Pattern Recognition Molecules on Pathogens

Auteurs: Götz MP, Duque Villegas MA, Fageräng B, Kerfin A, Skjoedt MO, Garred P, Rosbjerg A
Publié dans: Journal of Immunology, 2024, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.2300768

A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli

Auteurs: Fageräng B, Lau C, Mc Adam KE, Schjalm C, Christiansen D, Garred P, Nilsson PH, Mollnes TE
Publié dans: J Leukoc Biol, 2023, ISSN 1938-3673
Éditeur: John Wiley & Sons Inc
DOI: 10.1093/jleuko/qiad151

Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study

Auteurs: Henry BM, Sinkovits G, Szergyuk I, de Oliveira MHS, Lippi G, Benoit JL, Favaloro EJ, Pode-Shakked N, Benoit SW, Cooper DS, Müller V, Iványi Z, Gál J, Réti M, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Mező B, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z
Publié dans: Frontiers in Medicine, Numéro 2296858X, 2022, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/fmed.2022.796109

Droits de propriété intellectuelle

Patent (1)

METHODS FOR PREDICTING THE RISK OF DEVELOPING MULTISYSTEM INFLAMMATORY SYNDROME (MIS) FOLLOWING EXPOSURE TO AN INFECTIOUS AGENT AND FOR DIAGNOSING MIS FOLLOWING EXPOSURE TO AN INFECTIOUS AGENT

Numéro de demande/publication: 20 22050039
Date: 2022-05-02
Demandeur(s): UNIVERSITA HUMANITAS