Deliverables Other (1) ESR recruitment: All 15 ESRs are recruited; individual contracts are signed Management and overall coordination by VUMC will enable MIRIADE activities in all work packages to be performed timely coherently and efficiently One of these activities will be coordination of ESR recruitment Websites, patent fillings, videos etc. (1) Project website: The project website (intranet as well as internet) is up and running Secure efficient internal communication within the MIRIADE consortium Publications Peer reviewed articles (13) A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies Author(s): Sara Mravinacova, Malin Jönsson, Wanda Christ, Jonas Klingström, Jamil Yousef, Cecilia Hellström, My Hedhammar, Sebastian Havervall, Charlotte Thålin, Elisa Pin, Hanna Tegel, Peter Nilsson, Anna Månberg, Sophia Hober Published in: New Biotechnology, 2022, ISSN 1871-6784 Publisher: Elsevier BV DOI: 10.1016/j.nbt.2021.10.002 Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies Author(s): Maria C Gonzalez, Nicholas J Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas K Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E-DLB) Consortium Published in: JAMA Neurology, 2022, ISSN 2168-6149 Publisher: American Medical Association DOI: 10.1001/jamaneurol.2021.4222 Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome Author(s): Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Da Published in: Nature Communications, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-24319-x Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology Author(s): Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow Published in: Acta Neuropathologica, 2021, ISSN 0001-6322 Publisher: Springer Verlag DOI: 10.1007/s00401-021-02275-6 Fluid biomarkers in frontotemporal dementia: past,present and future Author(s): Imogen Joanna Swift, Aitana Sogorb-Esteve, Carolin Heller, Matthis Synofzik, Markus Otto, Caroline Graff, Daniela Galimberti, Emily Todd, Amanda J Heslegrave, Emma Louise van der Ende, John Cornelis Van Swieten, Henrik Zetterberg, Jonathan Daniel Rohrer Published in: Journal of neurology, neurosurgery, and psychiatry., 2021, ISSN 0022-3050 Publisher: BMJ Publishing Group DOI: 10.1136/jnnp-2020-323520 Blood-based biomarkers for Alzheimer's disease: towards clinical implementation Author(s): Charlotte E Teunissen, Inge M W Verberk, Elisabeth H Thijssen, Lisa Vermunt, Oskar Hansson, Henrik Zetterberg, Wiesje M van der Flier, Michelle M Mielke, Marta Del Campo Published in: The Lancet Neurology, 2022, ISSN 1474-4422 Publisher: The Lancet Publishing Group DOI: 10.1016/s1474-4422(21)00361-6 Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias Author(s): Daniel Alcolea, Constance Delaby, Laia Muñoz, Soraya Torres, Teresa Estellés, Nuole Zhu, Isabel Barroeta , María Carmona-Iragui, Ignacio Illán-Gala, Miguel Ángel Santos-Santos, Miren Altuna, Isabel Sala, Mª Belén Sánchez-Saudinós, Laura Videla, Sílvia Valldeneu, Andrea Subirana, Jordi Pegueroles, Christophe Hirtz, Jérôme Vialaret, Sylvain Lehmann, Thomas K Karikari, Nicholas J Ashton, Published in: Journal of Neurology, Neurosurgery and Psychiatry, 2021, ISSN 0022-3050 Publisher: BMJ Publishing Group DOI: 10.1136/jnnp-2021-326603 Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer’s disease Author(s): Sofia Bergström, Julia Remnestål, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Löwenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgård, Frederic Brosseron, Michael T Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Månberg, Per Svenningsson, Peter Nilsson Published in: Annals of Clinical and Translational Neurology, 2021, ISSN 2328-9503 Publisher: John Wiley and Sons Inc. DOI: 10.1002/acn3.51402 Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration Author(s): Nerea Gómez de San José; Federico Massa; Steffen Halbgebauer; Patrick Oeckl; Petra Steinacker; Markus Otto Published in: Neural Transmission, 2021, ISSN 0300-9564 Publisher: Springer Verlag DOI: 10.1007/s00702-021-02411-2 Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome Author(s): Alexandre Bejanin, Maria Florencia Iulita, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernandez, Miren Altuna, Jordi Pegueroles, Victor Montal, Silvia Valldeneu, Sandra Giménez, Sofía González-Ortiz, Laia Muñoz, Concepción Padilla, Mateus Rozalem Aranha, Teresa Estellés, Ignacio Illán-Gala, Olivia Belbin, Valle Camacho, Liam Reese Wilson, Ti Published in: JAMA Neurology, 2021, ISSN 2168-6149 Publisher: American Medical Association DOI: 10.1001/jamaneurol.2021.1893 Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview. Author(s): Constance Delaby, Charlotte E Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurélie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Céline Blanc-Quintin, Mercè Boada, Olivier Bousiges, Miles D Chapman, Mari L DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gab Published in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279 Publisher: John Wiley & Sons, Ltd DOI: 10.1002/alz.12545 Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group. Author(s): Inge M W Verberk, Els O Misdorp, Jannet Koelewijn, Andrew J Ball, Kaj Blennow, Jeffrey L Dage, Noelia Fandos, Oskar Hansson, Christophe Hirtz, Shorena Janelidze, Sungmin Kang, Kristopher Kirmess, Jana Kindermans, Ryan Lee, Matthew R Meyer, Dandan Shan, Leslie M Shaw, Teresa Waligorska, Tim West, Henrik Zetterberg, Rebecca M Edelmayer, Charlotte E Teunissen Published in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279 Publisher: John Wiley & Sons, Ltd DOI: 10.1002/alz.12510 Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217 and P-tau231 Author(s): Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen Published in: Alzheimer's Research & Therapy, 2021, ISSN 1758-9193 Publisher: BioMed Central DOI: 10.1186/s13195-021-00939-9 Conference proceedings (1) Clinical and analytical comparison of three assays for plasma p-tau isoforms on an ultrasensitive platform Author(s): Sherif Bayoumy, Ben Den Dulk, Zulaiga Hussainali, Inge M.W. Verberk, Wiesje M van der Flier, Marissa D. Zwan, Jeffrey L. Dage, Charlotte E. Teunissen Published in: Alzheimer’s and Dementia, 2021 Publisher: John Wiley & Sons, Ltd DOI: 10.1002/alz.054044 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
