Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis

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ESR recruitment: All 15 ESRs are recruited; individual contracts are signed

Management and overall coordination by VUMC will enable MIRIADE activities in all work packages to be performed timely coherently and efficiently One of these activities will be coordination of ESR recruitment

Project website: The project website (intranet as well as internet) is up and running

Secure efficient internal communication within the MIRIADE consortium

Publications

A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies

Auteurs: Sara Mravinacova, Malin Jönsson, Wanda Christ, Jonas Klingström, Jamil Yousef, Cecilia Hellström, My Hedhammar, Sebastian Havervall, Charlotte Thålin, Elisa Pin, Hanna Tegel, Peter Nilsson, Anna Månberg, Sophia Hober
Publié dans: New Biotechnology, 2022, ISSN 1871-6784
Éditeur: Elsevier BV
DOI: 10.1016/j.nbt.2021.10.002

Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies

Auteurs: Maria C Gonzalez, Nicholas J Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas K Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E-DLB) Consortium
Publié dans: JAMA Neurology, 2022, ISSN 2168-6149
Éditeur: American Medical Association
DOI: 10.1001/jamaneurol.2021.4222

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome

Auteurs: Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Da
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-24319-x

Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology

Auteurs: Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Publié dans: Acta Neuropathologica, 2021, ISSN 0001-6322
Éditeur: Springer Verlag
DOI: 10.1007/s00401-021-02275-6

Fluid biomarkers in frontotemporal dementia: past,present and future

Auteurs: Imogen Joanna Swift, Aitana Sogorb-Esteve, Carolin Heller, Matthis Synofzik, Markus Otto, Caroline Graff, Daniela Galimberti, Emily Todd, Amanda J Heslegrave, Emma Louise van der Ende, John Cornelis Van Swieten, Henrik Zetterberg, Jonathan Daniel Rohrer
Publié dans: Journal of neurology, neurosurgery, and psychiatry., 2021, ISSN 0022-3050
Éditeur: BMJ Publishing Group
DOI: 10.1136/jnnp-2020-323520

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Auteurs: Charlotte E Teunissen, Inge M W Verberk, Elisabeth H Thijssen, Lisa Vermunt, Oskar Hansson, Henrik Zetterberg, Wiesje M van der Flier, Michelle M Mielke, Marta Del Campo
Publié dans: The Lancet Neurology, 2022, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(21)00361-6

Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias

Auteurs: Daniel Alcolea, Constance Delaby, Laia Muñoz, Soraya Torres, Teresa Estellés, Nuole Zhu, Isabel Barroeta , María Carmona-Iragui, Ignacio Illán-Gala, Miguel Ángel Santos-Santos, Miren Altuna, Isabel Sala, Mª Belén Sánchez-Saudinós, Laura Videla, Sílvia Valldeneu, Andrea Subirana, Jordi Pegueroles, Christophe Hirtz, Jérôme Vialaret, Sylvain Lehmann, Thomas K Karikari, Nicholas J Ashton,
Publié dans: Journal of Neurology, Neurosurgery and Psychiatry, 2021, ISSN 0022-3050
Éditeur: BMJ Publishing Group
DOI: 10.1136/jnnp-2021-326603

Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer’s disease

Auteurs: Sofia Bergström, Julia Remnestål, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Löwenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgård, Frederic Brosseron, Michael T Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Månberg, Per Svenningsson, Peter Nilsson
Publié dans: Annals of Clinical and Translational Neurology, 2021, ISSN 2328-9503
Éditeur: John Wiley and Sons Inc.
DOI: 10.1002/acn3.51402

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Auteurs: Nerea Gómez de San José; Federico Massa; Steffen Halbgebauer; Patrick Oeckl; Petra Steinacker; Markus Otto
Publié dans: Neural Transmission, 2021, ISSN 0300-9564
Éditeur: Springer Verlag
DOI: 10.1007/s00702-021-02411-2

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

Auteurs: Alexandre Bejanin, Maria Florencia Iulita, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernandez, Miren Altuna, Jordi Pegueroles, Victor Montal, Silvia Valldeneu, Sandra Giménez, Sofía González-Ortiz, Laia Muñoz, Concepción Padilla, Mateus Rozalem Aranha, Teresa Estellés, Ignacio Illán-Gala, Olivia Belbin, Valle Camacho, Liam Reese Wilson, Ti
Publié dans: JAMA Neurology, 2021, ISSN 2168-6149
Éditeur: American Medical Association
DOI: 10.1001/jamaneurol.2021.1893

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview.

Auteurs: Constance Delaby, Charlotte E Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurélie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Céline Blanc-Quintin, Mercè Boada, Olivier Bousiges, Miles D Chapman, Mari L DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gab
Publié dans: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Éditeur: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12545

Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group.

Auteurs: Inge M W Verberk, Els O Misdorp, Jannet Koelewijn, Andrew J Ball, Kaj Blennow, Jeffrey L Dage, Noelia Fandos, Oskar Hansson, Christophe Hirtz, Shorena Janelidze, Sungmin Kang, Kristopher Kirmess, Jana Kindermans, Ryan Lee, Matthew R Meyer, Dandan Shan, Leslie M Shaw, Teresa Waligorska, Tim West, Henrik Zetterberg, Rebecca M Edelmayer, Charlotte E Teunissen
Publié dans: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Éditeur: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12510

Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217 and P-tau231

Auteurs: Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen
Publié dans: Alzheimer's Research & Therapy, 2021, ISSN 1758-9193
Éditeur: BioMed Central
DOI: 10.1186/s13195-021-00939-9

Clinical and analytical comparison of three assays for plasma p-tau isoforms on an ultrasensitive platform

Auteurs: Sherif Bayoumy, Ben Den Dulk, Zulaiga Hussainali, Inge M.W. Verberk, Wiesje M van der Flier, Marissa D. Zwan, Jeffrey L. Dage, Charlotte E. Teunissen
Publié dans: Alzheimer’s and Dementia, 2021
Éditeur: John Wiley & Sons, Ltd
DOI: 10.1002/alz.054044

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