ONCOgenic Receptor Network of Excellence and Training 2.0

Livrables

Kick-off GPCR symposium [month 7]; Final meeting [m42].

All ESRs have obtained a doctoral degree

Abstracts for international conferences and publications submitted; Publications submitted to appropriate journals. Website and social media presence built, maintained and operated. Appropriate reporting and production of content delivered on time and in full

ONCORNET2.0 website

ONCORNET website updated and online wwwoncorneteu

Publications

Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies.

Auteurs: Mark Soave; Mark Soave; Raimond Heukers; Barrie Kellam; Barrie Kellam; Jeanette Woolard; Jeanette Woolard; Martine J. Smit; Stephen J. Briddon; Stephen J. Briddon; Stephen J. Hill; Stephen J. Hill
Publié dans: VOLUME=27;ISSUE=10;STARTPAGE=1250;ENDPAGE=1261.e5;ISSN=2451-9456;TITLE=Cell Chemical Biology, Numéro 15;27(10), 2020, Page(s) 1250-1261, ISSN 2451-9448
Éditeur: Elsevier Inc.
DOI: 10.1016/j.chembiol.2020.06.006

The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy.

Auteurs: Schlecht-Louf G, Deback C, Bachelerie F.
Publié dans: Cancers, Numéro 14(3), 2022, Page(s) 848, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030848

Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts.

Auteurs: Docq M, Vétillard M, Gallego C, Jaracz-Ros A, Mercier-Nomé F, Bachelerie F, Schlecht-Louf G.
Publié dans: Cells, Numéro 2021 Nov 13;10(11):3153, 2021, Page(s) 3153-, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10113153

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors

Auteurs: Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A.
Publié dans: J Leukoc Biol, Numéro 107(6), 2020, Page(s) 1123-1135, ISSN 1938-3673
Éditeur: Wiley Online Library
DOI: 10.1002/jlb.2ma0320-383rr

The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology.

Auteurs: Laganà M, Schlecht-Louf G, Bachelerie F.
Publié dans: Cells, Numéro 10(1), 2021, Page(s) 75, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10010075

Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization.

Auteurs: Zarca A, Perez C, van den Bor J, Bebelman JP, Heuninck J, de Jonker RJF, Durroux T, Vischer HF, Siderius M, Smit MJ.
Publié dans: Cells, Numéro 2021 Mar 11;10(3):618, 2021, Page(s) 618-, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10030618

Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia

Auteurs: Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ.
Publié dans: Cells, Numéro 2020 Feb 14;9(2), 2020, Page(s) 444, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells9020444

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2.

Auteurs: Maria Neves; Cristina Perpiñá-Viciano; Petronila Penela; Petronila Penela; Carsten Hoffmann; Carsten Hoffmann; Federico Mayor; Federico Mayor
Publié dans: ACS Pharmacology & Translational Science, Numéro 1, 2020, Page(s) 627-634, ISSN 2575-9108
Éditeur: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.0c00021

New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance

Auteurs: Martyna Szpakowska, Giulia D’Uonnolo, Rafael Luı, Ana Alonso Bartolome, Marcus Thelen, Daniel F. Legler and Andy Chevigne
Publié dans: Front. Immunol., Numéro 14, 2023, Page(s) 01-11, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2023.1133394

Optical control of Class A G protein-coupled receptors with photoswitchable ligands.

Auteurs: Wijtmans M, Josimovic I, Vischer HF, Leurs R.
Publié dans: Curr Opin Pharmacol., Numéro 63, 2022, Page(s) 102192, ISSN 1471-4892
Éditeur: Elsevier BV
DOI: 10.1016/j.coph.2022.102192

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

Auteurs: Martine J. Smit, Géraldine Schlecht-Louf, Maria Neves, Jelle van den Bor, Petronila Penela, Marco Siderius, Françoise Bachelerie, Federico Mayor
Publié dans: Annual Review of Pharmacology and Toxicology, Numéro 61/1, 2021, Page(s) 541-563, ISSN 0362-1642
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-010919-023340

G protein-coupled receptors as promising targets in cancer

Auteurs: Claudia V. Perez Almeria, Irfan M. Setiawan, Marco Siderius, Martine J. Smit
Publié dans: Current Opinion in Endocrine and Metabolic Research, Numéro 16, 2021, Page(s) 119-127, ISSN 2451-9650
Éditeur: Elsevier
DOI: 10.1016/j.coemr.2020.10.005

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells

Auteurs: Comez Dehan, Glenn Jacqueline, Anbuhl Stephanie M., Heukers Raimond, Smit Martine J., Hill Stephen J., Kilpatrick Laura E.
Publié dans: Frontiers in Immunology, Numéro 13, 2022, Page(s) e, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.1006718

A new wrinkle for skin dendritic cell migration.

Auteurs: Cook DN, Nakano H.
Publié dans: Blood, Numéro 137(20), 2021, Page(s) 2716-2717, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020010619

HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources

Auteurs: Alizee Lebeau, Diane Bruyere, Patrick Roncarati, Paul Peixoto, Eric Hervouet, Gael Cobraiville, Bernard Taminiau, Murielle Masson, Carmen Gallego, Gabriel Mazzucchelli, Nicolas Smargiasso, Maximilien Fleron, Dominique Baiwir, Elodie Hendrick, Charlotte Pilard, Thomas Lerho, Celia Reynders, Marie Ancion, Roland Greimers, Jean-Claude Twizere, Georges Daube, Geraldine Schlecht-Louf, Françoise Bachel
Publié dans: Nature Communications, Numéro 2022 February 28, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-28724-8

CXCR4 as a novel target in immunology: moving away from typical antagonists

Auteurs: Birgit Caspar; Pietro Cocchiara; Armelle Melet; Kristof Van Emelen; Annegret Van der Aa; Graeme Milligan; Jean-Philippe Herbeuval
Publié dans: Future Science, Numéro 2, 2022, Page(s) e, ISSN 2056-5623
Éditeur: Future Science Ltd
DOI: 10.4155/fdd-2022-0007

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4

Auteurs: Cristina Perpiñá-Viciano, Ali Işbilir, Aurélien Zarca, Birgit Caspar, Laura E. Kilpatrick, Stephen J. Hill, Martine J. Smit, Martin J. Lohse, Carsten Hoffmann
Publié dans: Molecular Pharmacology, Numéro 98/2, 2020, Page(s) 72-87, ISSN 0026-895X
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.118448

Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.

Auteurs: Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ.
Publié dans: Proc Natl Acad Sci U S A., Numéro 2020 Nov 4:202013319, 117 (46), 2020, Page(s) 29144-29154, ISSN 1091-6490
Éditeur: National Academy of Science
DOI: 10.1073/pnas.2013319117

NanoB2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET

Auteurs: Jelle van den Bor, Nick D. Bergkamp, Stephanie M. Anbuhl, Françoise Dekker, Dehan Comez, Claudia V. Perez Almeria, Reggie Bosma, Carl W. White, Laura E. Kilpatrick, Stephen J. Hill, Marco Siderius, Martine J. Smit, and Raimond Heukers
Publié dans: Cell Rep Methods., Numéro 2023 Mar 27; 3(3): 100422., 2023, ISSN 2667-2375
Éditeur: Cell Press
DOI: 10.1016/j.crmeth.2023.100422

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor

Auteurs: Sebastian Dekkers, Birgit Caspar, Joëlle Goulding, Nicholas D. Kindon, Laura E. Kilpatrick, Leigh A. Stoddart, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill, and Michael J. Stocks
Publié dans: J. Med.Chem, Numéro 66, 2023, Page(s) 5208−5222, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00151

CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation.

Auteurs: Gallego C, Vétillard M, Calmette J, Roriz M, Marin-Esteban V, Evrard M, Aknin ML, Pionnier N, Lefrançois M, Mercier-Nomé F, Bertrand Y, Suarez F, Donadieu J, Ng LG, Balabanian K, Bachelerie F, Schlecht-Louf G.
Publié dans: Blood, Numéro 137(20), 2021, Page(s) 2770-2784, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020006675

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins.

Auteurs: Lambey P., Otun O., Cong X., Hoh F., Brunel L., Verdie P., Grison CM., Peysson F., Jeannot S., Durroux T., Bechara C., Granier S. and Leyrat C.
Publié dans: Elife, Numéro 2022 Mar 21;11:e72555, 2022, Page(s) e72555, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.72555

Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor.

Auteurs: Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, Babu MM, Volkman BF.
Publié dans: Science, Numéro 2022 Jul 8;377(6602), 2022, Page(s) 222-228, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.abj4922

Optimized protocol for 3D epithelial cultures supporting human papillomavirus replication.

Auteurs: Laganà M, Margolles GC, Jaracz-Ros A, et al.
Publié dans: STAR Protoc., Numéro 5(1), 2024, Page(s) 102828, ISSN 2666-1667
Éditeur: Elsevier
DOI: 10.1016/j.xpro.2023.102828

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3)

Auteurs: Sebastian Dekkers, Dehan Comez, Noemi Karsai, Marta Arimont-Segura, Meritxell Canals, Birgit Caspar, Chris de Graaf, Laura E. Kilpatrick, Rob Leurs, Barrie Kellam, Stephen J. Hill, Stephen J. Briddon, and Michael J. Stocks
Publié dans: ACS Med. Chem. Lett., Numéro 8 dec 2023, 2023, Page(s) online, ISSN 1948-5875
Éditeur: American Chemical Society
DOI: 10.1021/acsmedchemlett.3c00469

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.

Auteurs: Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P.
Publié dans: Nat Commun., Numéro 11(1), 2020, Page(s) 4855, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-18634-y

Crosstalk between CXCR4/ACKR3 and EGFR Signaling in Breast Cancer Cells.

Auteurs: Neves M, Marolda V, Mayor F Jr, Penela P.
Publié dans: Int J Mol Sci., Numéro 2022 Oct 6;23(19):11887, 2022, Page(s) 11887-, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911887

Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates.2023;. Published 2023 Nov 23. doi:10.1186/s40164-023-00460-9

Auteurs: Wakileh GA, Bierholz P, Kotthoff M, Skowron MA, Bremmer F, Stephan A, Anbuhl SM, Heukers R, Smit MJ, Ströbel P, Nettersheim D
Publié dans: Exp Hematol Oncol., Numéro 12(1):96, 2023, Page(s) online, ISSN 2162-3619
Éditeur: Springer Nature
DOI: 10.1186/s40164-023-00460-9

Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome.

Auteurs: Kumar R, Milanesi S, Szpakowska M, et al.
Publié dans: JCI Insight, Numéro 8(5), 2023, Page(s) e145688, ISSN 2379-3708
Éditeur: ASCI
DOI: 10.1172/jci.insight.145688

Reprogramming of connexin landscape fosters fast gap junction intercellular communication in human papillomavirus-infected epithelia

Auteurs: Carmen Gallego, Agnieszka Jaracz-Ros, Marta Laganà, Françoise Mercier-Nomé, Séverine Domenichini, Amos Fumagalli, Philippe Roingeard, Michael Herfs, Guillaume Pidoux, Françoise Bachelerie, Géraldine Schlecht-Louf
Publié dans: Front Cell Infect Microbiol ., Numéro 2023 May 16;13:1138232., 2023, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1138232

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions

Auteurs: Fasciani I, Petragnano F, Wang Z, Edwards R, Telugu N, Pietrantoni I, et al.
Publié dans: PLoS Biol, Numéro 22(4), 2024, Page(s) e3002582, ISSN 1545-7885
Éditeur: x
DOI: 10.1371/journal.pbio.3002582

Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist for the atypical chemokine receptor ACKR3

Auteurs: Aurelien M. Zarca, Ilze Adlere, Cristina P. Viciano, Marta Arimont-Segura, Max Meyrath, Icaro A. Simon, Jan Paul Bebelman, Dennis Laan, Hans G. J. Custers, Elwin Janssen, Kobus L. Versteegh, Reggie Bosma, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans, Martyna Szpakowska, Andy Chevigné, Carsten Hoffmann, Chris de Graaf, Barbara A. Zarzycka, Albert D. Windhorst, Martine J. Sm
Publié dans: Molecular Pharmacology, Numéro 2024 Feb 12:MOLPHARM-AR-2023-000835, 2024, Page(s) online, ISSN 1521-0111
Éditeur: ASPET
DOI: 10.1124/molpharm.123.000835

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation.

Auteurs: Omolade Otun, Christelle Aljamous, Elise Del Nero, Marta Arimont-Segura, Reggie Bosma, Barbara Zarzycka, Tristan Girbau, Cédric Leyrat, Chris de Graaf, Rob Leurs, Thierry Durroux, Sebastien Granier, Xiaojing Cong, Cherine Bechara.
Publié dans: BioRxiv, 2023, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.07.17.549382

GRK specificity and Gβγ dependency determines a GPCR’s potential in biased agonism

Auteurs: Edda S. F. Matthees, Jenny C. Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Julia Drube, Amod Godbole, Carsten Hoffmann
Publié dans: BioRxiv, 2023, ISSN 2692-8205
Éditeur: Cold Sprink Harbor Laboratory
DOI: 10.1101/2023.07.14.548990

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