ONCOgenic Receptor Network of Excellence and Training 2.0

Deliverables

Websites, patent fillings, videos etc. (1)

ONCORNET2.0 website

ONCORNET website updated and online wwwoncorneteu

Publications

Peer reviewed articles (12)

Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies.

Author(s): Mark Soave; Mark Soave; Raimond Heukers; Barrie Kellam; Barrie Kellam; Jeanette Woolard; Jeanette Woolard; Martine J. Smit; Stephen J. Briddon; Stephen J. Briddon; Stephen J. Hill; Stephen J. Hill
Published in: VOLUME=27;ISSUE=10;STARTPAGE=1250;ENDPAGE=1261.e5;ISSN=2451-9456;TITLE=Cell Chemical Biology, 15;27(10), 2020, Page(s) 1250-1261, ISSN 2451-9448
Publisher: Elsevier Inc.
DOI: 10.1016/j.chembiol.2020.06.006

The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy.

Author(s): Schlecht-Louf G, Deback C, Bachelerie F.
Published in: Cancers, 14(3), 2022, Page(s) 848, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030848

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors

Author(s): Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A.
Published in: J Leukoc Biol, 107(6), 2020, Page(s) 1123-1135, ISSN 1938-3673
Publisher: Wiley Online Library
DOI: 10.1002/jlb.2ma0320-383rr

The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology.

Author(s): Laganà M, Schlecht-Louf G, Bachelerie F.
Published in: Cells, 10(1), 2021, Page(s) 75, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010075

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2.

Author(s): Maria Neves; Cristina Perpiñá-Viciano; Petronila Penela; Petronila Penela; Carsten Hoffmann; Carsten Hoffmann; Federico Mayor; Federico Mayor
Published in: ACS Pharmacology & Translational Science, 1, 2020, Page(s) 627-634, ISSN 2575-9108
Publisher: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.0c00021

Optical control of Class A G protein-coupled receptors with photoswitchable ligands.

Author(s): Wijtmans M, Josimovic I, Vischer HF, Leurs R.
Published in: Curr Opin Pharmacol., 63, 2022, Page(s) 102192, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2022.102192

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

Author(s): Martine J. Smit, Géraldine Schlecht-Louf, Maria Neves, Jelle van den Bor, Petronila Penela, Marco Siderius, Françoise Bachelerie, Federico Mayor
Published in: Annual Review of Pharmacology and Toxicology, 61/1, 2021, Page(s) 541-563, ISSN 0362-1642
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-010919-023340

G protein-coupled receptors as promising targets in cancer

Author(s): Claudia V. Perez Almeria, Irfan M. Setiawan, Marco Siderius, Martine J. Smit
Published in: Current Opinion in Endocrine and Metabolic Research, 16, 2021, Page(s) 119-127, ISSN 2451-9650
Publisher: Elsevier
DOI: 10.1016/j.coemr.2020.10.005

A new wrinkle for skin dendritic cell migration.

Author(s): Cook DN, Nakano H.
Published in: Blood, 137(20), 2021, Page(s) 2716-2717, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020010619

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4

Author(s): Cristina Perpiñá-Viciano, Ali Işbilir, Aurélien Zarca, Birgit Caspar, Laura E. Kilpatrick, Stephen J. Hill, Martine J. Smit, Martin J. Lohse, Carsten Hoffmann
Published in: Molecular Pharmacology, 98/2, 2020, Page(s) 72-87, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.118448

CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation.

Author(s): Gallego C, Vétillard M, Calmette J, Roriz M, Marin-Esteban V, Evrard M, Aknin ML, Pionnier N, Lefrançois M, Mercier-Nomé F, Bertrand Y, Suarez F, Donadieu J, Ng LG, Balabanian K, Bachelerie F, Schlecht-Louf G.
Published in: Blood, 137(20), 2021, Page(s) 2770-2784, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020006675

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.

Author(s): Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P.
Published in: Nat Commun., 11(1), 2020, Page(s) 4855, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18634-y