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ONCOgenic Receptor Network of Excellence and Training 2.0


ONCORNET2.0 website

ONCORNET website updated and online wwwoncorneteu


Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies.

Author(s): Mark Soave; Mark Soave; Raimond Heukers; Barrie Kellam; Barrie Kellam; Jeanette Woolard; Jeanette Woolard; Martine J. Smit; Stephen J. Briddon; Stephen J. Briddon; Stephen J. Hill; Stephen J. Hill
Published in: VOLUME=27;ISSUE=10;STARTPAGE=1250;ENDPAGE=1261.e5;ISSN=2451-9456;TITLE=Cell Chemical Biology, 15;27(10), 2020, Page(s) 1250-1261, ISSN 2451-9448
Publisher: Elsevier Inc.
DOI: 10.1016/j.chembiol.2020.06.006

The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy.

Author(s): Schlecht-Louf G, Deback C, Bachelerie F.
Published in: Cancers, 14(3), 2022, Page(s) 848, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030848

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors

Author(s): Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A.
Published in: J Leukoc Biol, 107(6), 2020, Page(s) 1123-1135, ISSN 1938-3673
Publisher: Wiley Online Library
DOI: 10.1002/jlb.2ma0320-383rr

The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology.

Author(s): Laganà M, Schlecht-Louf G, Bachelerie F.
Published in: Cells, 10(1), 2021, Page(s) 75, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010075

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2.

Author(s): Maria Neves; Cristina Perpiñá-Viciano; Petronila Penela; Petronila Penela; Carsten Hoffmann; Carsten Hoffmann; Federico Mayor; Federico Mayor
Published in: ACS Pharmacology & Translational Science, 1, 2020, Page(s) 627-634, ISSN 2575-9108
Publisher: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.0c00021

Optical control of Class A G protein-coupled receptors with photoswitchable ligands.

Author(s): Wijtmans M, Josimovic I, Vischer HF, Leurs R.
Published in: Curr Opin Pharmacol., 63, 2022, Page(s) 102192, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2022.102192

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

Author(s): Martine J. Smit, Géraldine Schlecht-Louf, Maria Neves, Jelle van den Bor, Petronila Penela, Marco Siderius, Françoise Bachelerie, Federico Mayor
Published in: Annual Review of Pharmacology and Toxicology, 61/1, 2021, Page(s) 541-563, ISSN 0362-1642
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-010919-023340

G protein-coupled receptors as promising targets in cancer

Author(s): Claudia V. Perez Almeria, Irfan M. Setiawan, Marco Siderius, Martine J. Smit
Published in: Current Opinion in Endocrine and Metabolic Research, 16, 2021, Page(s) 119-127, ISSN 2451-9650
Publisher: Elsevier
DOI: 10.1016/j.coemr.2020.10.005

A new wrinkle for skin dendritic cell migration.

Author(s): Cook DN, Nakano H.
Published in: Blood, 137(20), 2021, Page(s) 2716-2717, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020010619

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4

Author(s): Cristina Perpiñá-Viciano, Ali Işbilir, Aurélien Zarca, Birgit Caspar, Laura E. Kilpatrick, Stephen J. Hill, Martine J. Smit, Martin J. Lohse, Carsten Hoffmann
Published in: Molecular Pharmacology, 98/2, 2020, Page(s) 72-87, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.118448

CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation.

Author(s): Gallego C, Vétillard M, Calmette J, Roriz M, Marin-Esteban V, Evrard M, Aknin ML, Pionnier N, Lefrançois M, Mercier-Nomé F, Bertrand Y, Suarez F, Donadieu J, Ng LG, Balabanian K, Bachelerie F, Schlecht-Louf G.
Published in: Blood, 137(20), 2021, Page(s) 2770-2784, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020006675

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.

Author(s): Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P.
Published in: Nat Commun., 11(1), 2020, Page(s) 4855, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18634-y