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ONCOgenic Receptor Network of Excellence and Training 2.0

Deliverables

ONCORNET2.0 website

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Publications

Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies.

Author(s): Mark Soave; Mark Soave; Raimond Heukers; Barrie Kellam; Barrie Kellam; Jeanette Woolard; Jeanette Woolard; Martine J. Smit; Stephen J. Briddon; Stephen J. Briddon; Stephen J. Hill; Stephen J. Hill
Published in: VOLUME=27;ISSUE=10;STARTPAGE=1250;ENDPAGE=1261.e5;ISSN=2451-9456;TITLE=Cell Chemical Biology, 15;27(10), 2020, Page(s) 1250-1261, ISSN 2451-9448
Publisher: Elsevier Inc.
DOI: 10.1016/j.chembiol.2020.06.006

The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy.

Author(s): Schlecht-Louf G, Deback C, Bachelerie F.
Published in: Cancers, 14(3), 2022, Page(s) 848, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030848

Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts. 

Author(s): Docq M, Vétillard M, Gallego C, Jaracz-Ros A, Mercier-Nomé F, Bachelerie F, Schlecht-Louf G.
Published in: Cells, 2021 Nov 13;10(11):3153, 2021, Page(s) 3153-, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10113153

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors

Author(s): Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A.
Published in: J Leukoc Biol, 107(6), 2020, Page(s) 1123-1135, ISSN 1938-3673
Publisher: Wiley Online Library
DOI: 10.1002/jlb.2ma0320-383rr

The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology.

Author(s): Laganà M, Schlecht-Louf G, Bachelerie F.
Published in: Cells, 10(1), 2021, Page(s) 75, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010075

Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization.

Author(s): Zarca A, Perez C, van den Bor J, Bebelman JP, Heuninck J, de Jonker RJF, Durroux T, Vischer HF, Siderius M, Smit MJ.
Published in: Cells, 2021 Mar 11;10(3):618, 2021, Page(s) 618-, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10030618

Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia

Author(s): Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ.
Published in: Cells, 2020 Feb 14;9(2), 2020, Page(s) 444, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells9020444

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2.

Author(s): Maria Neves; Cristina Perpiñá-Viciano; Petronila Penela; Petronila Penela; Carsten Hoffmann; Carsten Hoffmann; Federico Mayor; Federico Mayor
Published in: ACS Pharmacology & Translational Science, 1, 2020, Page(s) 627-634, ISSN 2575-9108
Publisher: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.0c00021

Optical control of Class A G protein-coupled receptors with photoswitchable ligands.

Author(s): Wijtmans M, Josimovic I, Vischer HF, Leurs R.
Published in: Curr Opin Pharmacol., 63, 2022, Page(s) 102192, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2022.102192

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

Author(s): Martine J. Smit, Géraldine Schlecht-Louf, Maria Neves, Jelle van den Bor, Petronila Penela, Marco Siderius, Françoise Bachelerie, Federico Mayor
Published in: Annual Review of Pharmacology and Toxicology, 61/1, 2021, Page(s) 541-563, ISSN 0362-1642
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-010919-023340

G protein-coupled receptors as promising targets in cancer

Author(s): Claudia V. Perez Almeria, Irfan M. Setiawan, Marco Siderius, Martine J. Smit
Published in: Current Opinion in Endocrine and Metabolic Research, 16, 2021, Page(s) 119-127, ISSN 2451-9650
Publisher: Elsevier
DOI: 10.1016/j.coemr.2020.10.005

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells

Author(s): Comez Dehan, Glenn Jacqueline, Anbuhl Stephanie M., Heukers Raimond, Smit Martine J., Hill Stephen J., Kilpatrick Laura E.
Published in: Frontiers in Immunology, 13, 2022, Page(s) e, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.1006718

A new wrinkle for skin dendritic cell migration.

Author(s): Cook DN, Nakano H.
Published in: Blood, 137(20), 2021, Page(s) 2716-2717, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020010619

CXCR4 as a novel target in immunology: moving away from typical antagonists

Author(s): Birgit Caspar; Pietro Cocchiara; Armelle Melet; Kristof Van Emelen; Annegret Van der Aa; Graeme Milligan; Jean-Philippe Herbeuval
Published in: Future Science, 2, 2022, Page(s) e, ISSN 2056-5623
Publisher: Future Science Ltd
DOI: 10.4155/fdd-2022-0007

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4

Author(s): Cristina Perpiñá-Viciano, Ali Işbilir, Aurélien Zarca, Birgit Caspar, Laura E. Kilpatrick, Stephen J. Hill, Martine J. Smit, Martin J. Lohse, Carsten Hoffmann
Published in: Molecular Pharmacology, 98/2, 2020, Page(s) 72-87, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.118448

Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.

Author(s): Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ. 
Published in: Proc Natl Acad Sci U S A., 2020 Nov 4:202013319, 117 (46), 2020, Page(s) 29144-29154, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2013319117

CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation.

Author(s): Gallego C, Vétillard M, Calmette J, Roriz M, Marin-Esteban V, Evrard M, Aknin ML, Pionnier N, Lefrançois M, Mercier-Nomé F, Bertrand Y, Suarez F, Donadieu J, Ng LG, Balabanian K, Bachelerie F, Schlecht-Louf G.
Published in: Blood, 137(20), 2021, Page(s) 2770-2784, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020006675

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins.

Author(s): Lambey P., Otun O., Cong X., Hoh F., Brunel L., Verdie P., Grison CM., Peysson F., Jeannot S., Durroux T., Bechara C., Granier S. and  Leyrat C.
Published in: Elife, 2022 Mar 21;11:e72555, 2022, Page(s) e72555, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.72555

Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. 

Author(s): Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, Babu MM, Volkman BF.
Published in: Science, 2022 Jul 8;377(6602), 2022, Page(s) 222-228, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abj4922

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.

Author(s): Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P.
Published in: Nat Commun., 11(1), 2020, Page(s) 4855, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18634-y

Crosstalk between CXCR4/ACKR3 and EGFR Signaling in Breast Cancer Cells.

Author(s): Neves M, Marolda V, Mayor F Jr, Penela P.
Published in: Int J Mol Sci., 2022 Oct 6;23(19):11887, 2022, Page(s) 11887-, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911887