Descripción del proyecto
Comprender la regulación de las células embrionarias podría arrojar luz sobre numerosas patologías
Las células de la cresta neural son un grupo transitorio de células embrionarias que migran ampliamente, formando no solo la mayor parte del sistema nervioso periférico, sino también células de las glándulas suprarrenales, células musculares del sistema cardiovascular, células pigmentarias de la piel y huesos craneofaciales, cartílago y tejido conjuntivo. Las neurocristopatías (NCP, por sus siglas en inglés) son el resultado de anomalías en las células de la cresta neural, y algunos cánceres, como el melanoma y el neuroblastoma, están vinculados con ellas. Sin embargo, es difícil seguir las patologías hasta mutaciones específicas en estas células. NEUcrest aprovecha los recursos de investigadores noveles para desentrañar los aspectos complejos de la formación de las células neurales y los tumores y, más en general, la regulación del tejido de las células neurales en la salud humana.
Objetivo
Neurocristopathies caused by defects in the neural crest (NC) encompass a broad group of diseases from birth defects (cleftvpalate) to complex syndromes affecting systems such as heart, gut and adrenals. Because NC derivatives are diverse, mutations affecting this lineage can lead to pleiotropic phenotypes making it difficult to understand the causative events. Furthermore, NC-derived cancers, (e.g. melanoma and neuroblastoma) reactivate embryonic programs during tumour initiation. Our aim is to create a unique interdisciplinary network of scientists and clinicians partners from academia, healthcare, industry and the public sector with experience in gene discovery, genetics, functional studies and in vivo phenotyping aimed at training creative and innovative ESRs to study the overall genetic, molecular and environmental regulation of NC tissue in human health. To study each of complex aspects of NC and tumour formation, NEUcrest provides a synergistic framework for comprehensive analysis of candidate genes and biological processes, from patients to model systems to pharma and back to the clinic. With the aim to develop a unified strategy to identify new genetic and environmental factors that contribute to disease and to develop new drug targets for therapeutics, ESRs will address following scientific challenges: undertake novel gene discovery approaches; establish cellular/animal models of disease; establish integrative strategies for understanding neurocristopathies; optimise computational modelling of NC gene networks; establish translational strategies for drug screening in NC-related diseases; improve clinical management strategies of NC-disease and interface with patients and the public. Our training program takes into account training through research as well as multidisciplinary partnerships and networking opportunities. All together, this will improve our understanding of the fundamentals of neurocristopathy and contribute to improvements in healthcare.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
75231 Paris
Francia