Translational SYStemics: Personalised Medicine at the Interface of Translational Research and Systems Medicine

Project Information

TranSYS

Grant agreement ID: 860895

DOI 10.3030/860895

Project closed

EC signature date 19 August 2019

Start date 1 September 2019

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 916 285,67

EU contribution € 3 916 285,67

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

TranSYS guidelines & recommendations for CT design

TranSYS guidelines & recommendations for clinical trials design for Personalized Medicine and targeted drug treatment modalities

TranSYS white paper II

TranSYS white paper II: Road Map to develop an omics data-integrative PGx panel enhancing early molecular diagnosis of patients (WP1) and stratified PM in practice (WP3)

TranSYS white paper I

TranSYS white paper I: data integrative analytic strategies and hybrid approaches, implementations and role in PM

Economic model of the developed and validated preemptive pharmacogenomics genotyping panels

ESR14: Economic model of the developed and validated preemptive pharmacogenomics genotyping panels

Ethics plan and recommendations regarding emerging moral questions in personalized medicine

ESR4: Ethics plan and recommendations regarding emerging moral questions in personalized medicine

Open Science summary of all ETN research results

Open Science summary of all ETN research results via website

Demonstrators, pilots, prototypes (5)

A multi-level data integrative framework and tool for validation, interpretation and translation of multi-level patient subtyping

ESR2: A multi-level data integrative framework and tool for validation, interpretation and translation of multi-level patient subtyping

A multi-omics patient stratification strategy and tool using advanced pattern recognition for PM

ESR3: A multi-omics patient stratification strategy and tool using advanced pattern recognition for PM

User friendly app for LifeLines-Deep participants to consult a personal pharmacogenetic passport

ESR12: User friendly app for LifeLines-Deep participants to consult a personal pharmacogenetic passport

Pipeline for individual-specific network construction and corresponding module detection/comparison schemes

ESR1: Pipeline for individual-specific network construction and corresponding module detection/comparison schemes

Description of decentralized software ecosystem and acquired understanding of clinical trial related blockchain technology

ESR10: Description of decentralized software ecosystem and acquired understanding of clinical trial related blockchain technology

Other (5)

TranSYS School 1

Lead overlooking Body Training Council Natasa Przulj Details Annex 1 Part B Table 22b

Doctoral Schools

ESRs enrolled in doctoral school programmes regulated by M12

TranSYS School 3

Lead overlooking Body: Training Council (Natasa Przulj); Details Annex 1 - Part B - Table 2.2b

TranSYS Flagship conference event

Closing conference

TranSYS School 2

Lead overlooking Body: Training Council (Natasa Przulj); Details Annex 1 - Part B - Table 2.2b

Websites, patent fillings, videos etc. (2)

TranSYS intranet and extranet / SharePoint in place

Website for data sharing internal CO external PU Sharepoint for easy filling of reports and sharing documents within WGs within TranSYS Boards within TranSYS at large

TranSYS recruitment pages online with ESR vacancies posted (recruitment process+gender plan)

Publications

Peer reviewed articles (12)

Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections

Author(s): Katz, Sonja; Suijker, Jaco; Hardt, Christopher; Madsen, Martin Bruun; Meij de Vries, Annebeth; Pijpe, Anouk; Skrede, Steinar; Hyldegaard, Ole; Solligård, Erik; Norrby-Teglund, Anna; Saccenti, Edoardo; Martins dos Santos, Vitor A.P.
Published in: Int J Med Inform., Issue 167, 2022, ISSN 1386-5056
Publisher: Elsevier BV
DOI: 10.1016/j.ijmedinf.2022.104878

Economic evaluation in psychiatric pharmacogenomics: a systematic review

Author(s): Kariofyllis Karamperis, Maria Koromina, Panagiotis Papantoniou, Maria Skokou, Filippos Kanellakis, Konstantinos Mitropoulos, Athanassios Vozikis, Daniel J. Müller, George P. Patrinos, Christina Mitropoulou
Published in: The Pharmacogenomics Journal, Issue 21/4, 2021, Page(s) 533-541, ISSN 1470-269X
Publisher: Nature Publishing Group
DOI: 10.1038/s41397-021-00249-1

Guided extraction of genome-scale metabolic models for the integration and analysis of omics data

Author(s): Andrew Walakira, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon
Published in: Computational and Structural Biotechnology Journal, Issue 19, 2021, Page(s) 3521-3530, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2021.06.009

Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics

Author(s): Maria Koromina, Stefania Koutsilieri, George P. Patrinos
Published in: Human Genomics, Issue 14/1, 2020, ISSN 1479-7364
Publisher: Springer Nature
DOI: 10.1186/s40246-019-0254-y

Individual-specific networks for prediction modelling – A scoping review of methods

Author(s): Gregorich, Mariella; Melograna, Federico; Sunqvist, Martina; Michiels, Stefan; van Steen, Kristel; Heinze, Georg
Published in: BMC Med Res Methodol, Issue 22, 2022, Page(s) 62, ISSN 1471-2288
Publisher: BioMed Central
DOI: 10.1186/s12874-022-01544-6

Integrative computational modeling to unravel novel potential biomarkers in hepatocellular carcinoma

Author(s): Andrew Walakira, Cene Skubic, Nejc Nadižar, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon,
Published in: Computers in Biology and Medicine, 2023, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.106957

The AIMe registry for artificial intelligence in biomedical research.

Author(s): Julian Matschinske; Julian Matschinske; Nicolas Alcaraz; Arriel Benis; Martin Golebiewski; Dominik G. Grimm; Dominik G. Grimm; Lukas Heumos; Tim Kacprowski; Tim Kacprowski; Tim Kacprowski; Olga Lazareva; Markus List; Zakaria Louadi; Zakaria Louadi; Josch Konstantin Pauling; Nico Pfeifer; Richard Röttger; Veit Schwämmle; Gregor Sturm; Alberto Traverso; Kristel Van Steen; Kristel Van Steen; Martie
Published in: VOLUME=18;ISSUE=10;STARTPAGE=1128;ENDPAGE=1131;ISSN=1548-7091;TITLE=Nature Methods, Issue 2, 2021, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01241-0

Taking the risk. A systematic review of ethical reasons and moral arguments in the clinical use of polygenic risk scores

Author(s): Lara Andreoli, Hilde Peeters, Kristel Van Steen, Kris Dierickx
Published in: American Journal of medical genetics, Issue 194 issue 7, 2024, ISSN 1552-4825
Publisher: Wiley-Liss Inc
DOI: 10.1002/ajmg.a.63584

Detecting gene–gene interactions from GWAS using diffusion kernel principal components

Author(s): Andrew Walakira; Junior Ocira; Diane Duroux; Ramouna Fouladi; Miha Moškon; Damjana Rozman; Kristel Van Steen
Published in: BMC Bioinformatics 23, Issue 1, 2022, Page(s) Article number: 57 (2022), ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-022-04580-7

An overview of machine learning methods for monotherapy drug response prediction

Author(s): Farzaneh Firoozbakht, Behnam Yousefi, Benno Schwikowski
Published in: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbab408

PLEX.I: a tool to discover features in multiplex networks that reflect clinical variation

Author(s): Behnam Yousefi; Behnam Yousefi; Behnam Yousefi; Farzaneh Firoozbakht; Federico Melograna; Benno Schwikowski; Kristel Van Steen; Kristel Van Steen
Published in: Frontiers in Genetics, Issue 3, 2023, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2023.1274637

Capturing the dynamics of microbial interactions through individual-specific networks

Author(s): Behnam Yousefi; Behnam Yousefi; Behnam Yousefi; Federico Melograna; Gianluca Galazzo; Niels van Best; Niels van Best; Monique Mommers; John Penders; John Penders; Benno Schwikowski; Kristel Van Steen; Kristel Van Steen
Published in: Frontiers in microbiology., Issue 14:1170391, 2023, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1170391