Translational SYStemics: Personalised Medicine at the Interface of Translational Research and Systems Medicine

Informations projet

TranSYS

N° de convention de subvention: 860895

DOI

10.3030/860895

Projet clôturé

Date de signature de la CE 19 Août 2019

Date de début 1 Septembre 2019

Date de fin 30 Juin 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 916 285,67

Contribution de l’UE

€ 3 916 285,67

Coordonné par

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

TranSYS guidelines & recommendations for CT design

TranSYS guidelines & recommendations for clinical trials design for Personalized Medicine and targeted drug treatment modalities

TranSYS white paper II

TranSYS white paper II: Road Map to develop an omics data-integrative PGx panel enhancing early molecular diagnosis of patients (WP1) and stratified PM in practice (WP3)

TranSYS white paper I

TranSYS white paper I: data integrative analytic strategies and hybrid approaches, implementations and role in PM

Economic model of the developed and validated preemptive pharmacogenomics genotyping panels

ESR14: Economic model of the developed and validated preemptive pharmacogenomics genotyping panels

Ethics plan and recommendations regarding emerging moral questions in personalized medicine

ESR4: Ethics plan and recommendations regarding emerging moral questions in personalized medicine

Open Science summary of all ETN research results

Open Science summary of all ETN research results via website

Demonstrators, pilots, prototypes (5)

A multi-level data integrative framework and tool for validation, interpretation and translation of multi-level patient subtyping

ESR2: A multi-level data integrative framework and tool for validation, interpretation and translation of multi-level patient subtyping

A multi-omics patient stratification strategy and tool using advanced pattern recognition for PM

ESR3: A multi-omics patient stratification strategy and tool using advanced pattern recognition for PM

User friendly app for LifeLines-Deep participants to consult a personal pharmacogenetic passport

ESR12: User friendly app for LifeLines-Deep participants to consult a personal pharmacogenetic passport

Pipeline for individual-specific network construction and corresponding module detection/comparison schemes

ESR1: Pipeline for individual-specific network construction and corresponding module detection/comparison schemes

Description of decentralized software ecosystem and acquired understanding of clinical trial related blockchain technology

ESR10: Description of decentralized software ecosystem and acquired understanding of clinical trial related blockchain technology

Other (5)

TranSYS School 1

Lead overlooking Body Training Council Natasa Przulj Details Annex 1 Part B Table 22b

Doctoral Schools

ESRs enrolled in doctoral school programmes regulated by M12

TranSYS School 3

Lead overlooking Body: Training Council (Natasa Przulj); Details Annex 1 - Part B - Table 2.2b

TranSYS Flagship conference event

Closing conference

TranSYS School 2

Lead overlooking Body: Training Council (Natasa Przulj); Details Annex 1 - Part B - Table 2.2b

Websites, patent fillings, videos etc. (2)

TranSYS intranet and extranet / SharePoint in place

Website for data sharing internal CO external PU Sharepoint for easy filling of reports and sharing documents within WGs within TranSYS Boards within TranSYS at large

TranSYS recruitment pages online with ESR vacancies posted (recruitment process+gender plan)

Publications

Peer reviewed articles (12)

Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections

Auteurs: Katz, Sonja; Suijker, Jaco; Hardt, Christopher; Madsen, Martin Bruun; Meij de Vries, Annebeth; Pijpe, Anouk; Skrede, Steinar; Hyldegaard, Ole; Solligård, Erik; Norrby-Teglund, Anna; Saccenti, Edoardo; Martins dos Santos, Vitor A.P.
Publié dans: Int J Med Inform., Numéro 167, 2022, ISSN 1386-5056
Éditeur: Elsevier BV
DOI: 10.1016/j.ijmedinf.2022.104878

Economic evaluation in psychiatric pharmacogenomics: a systematic review

Auteurs: Kariofyllis Karamperis, Maria Koromina, Panagiotis Papantoniou, Maria Skokou, Filippos Kanellakis, Konstantinos Mitropoulos, Athanassios Vozikis, Daniel J. Müller, George P. Patrinos, Christina Mitropoulou
Publié dans: The Pharmacogenomics Journal, Numéro 21/4, 2021, Page(s) 533-541, ISSN 1470-269X
Éditeur: Nature Publishing Group
DOI: 10.1038/s41397-021-00249-1

Guided extraction of genome-scale metabolic models for the integration and analysis of omics data

Auteurs: Andrew Walakira, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon
Publié dans: Computational and Structural Biotechnology Journal, Numéro 19, 2021, Page(s) 3521-3530, ISSN 2001-0370
Éditeur: Elsevier
DOI: 10.1016/j.csbj.2021.06.009

Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics

Auteurs: Maria Koromina, Stefania Koutsilieri, George P. Patrinos
Publié dans: Human Genomics, Numéro 14/1, 2020, ISSN 1479-7364
Éditeur: Springer Nature
DOI: 10.1186/s40246-019-0254-y

Individual-specific networks for prediction modelling – A scoping review of methods

Auteurs: Gregorich, Mariella; Melograna, Federico; Sunqvist, Martina; Michiels, Stefan; van Steen, Kristel; Heinze, Georg
Publié dans: BMC Med Res Methodol, Numéro 22, 2022, Page(s) 62, ISSN 1471-2288
Éditeur: BioMed Central
DOI: 10.1186/s12874-022-01544-6

Integrative computational modeling to unravel novel potential biomarkers in hepatocellular carcinoma

Auteurs: Andrew Walakira, Cene Skubic, Nejc Nadižar, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon,
Publié dans: Computers in Biology and Medicine, 2023, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.106957

The AIMe registry for artificial intelligence in biomedical research.

Auteurs: Julian Matschinske; Julian Matschinske; Nicolas Alcaraz; Arriel Benis; Martin Golebiewski; Dominik G. Grimm; Dominik G. Grimm; Lukas Heumos; Tim Kacprowski; Tim Kacprowski; Tim Kacprowski; Olga Lazareva; Markus List; Zakaria Louadi; Zakaria Louadi; Josch Konstantin Pauling; Nico Pfeifer; Richard Röttger; Veit Schwämmle; Gregor Sturm; Alberto Traverso; Kristel Van Steen; Kristel Van Steen; Martie
Publié dans: VOLUME=18;ISSUE=10;STARTPAGE=1128;ENDPAGE=1131;ISSN=1548-7091;TITLE=Nature Methods, Numéro 2, 2021, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-021-01241-0

Taking the risk. A systematic review of ethical reasons and moral arguments in the clinical use of polygenic risk scores

Auteurs: Lara Andreoli, Hilde Peeters, Kristel Van Steen, Kris Dierickx
Publié dans: American Journal of medical genetics, Numéro 194 issue 7, 2024, ISSN 1552-4825
Éditeur: Wiley-Liss Inc
DOI: 10.1002/ajmg.a.63584

Detecting gene–gene interactions from GWAS using diffusion kernel principal components

Auteurs: Andrew Walakira; Junior Ocira; Diane Duroux; Ramouna Fouladi; Miha Moškon; Damjana Rozman; Kristel Van Steen
Publié dans: BMC Bioinformatics 23, Numéro 1, 2022, Page(s) Article number: 57 (2022), ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-022-04580-7

An overview of machine learning methods for monotherapy drug response prediction

Auteurs: Farzaneh Firoozbakht, Behnam Yousefi, Benno Schwikowski
Publié dans: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbab408

PLEX.I: a tool to discover features in multiplex networks that reflect clinical variation

Auteurs: Behnam Yousefi; Behnam Yousefi; Behnam Yousefi; Farzaneh Firoozbakht; Federico Melograna; Benno Schwikowski; Kristel Van Steen; Kristel Van Steen
Publié dans: Frontiers in Genetics, Numéro 3, 2023, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2023.1274637

Capturing the dynamics of microbial interactions through individual-specific networks

Auteurs: Behnam Yousefi; Behnam Yousefi; Behnam Yousefi; Federico Melograna; Gianluca Galazzo; Niels van Best; Niels van Best; Monique Mommers; John Penders; John Penders; Benno Schwikowski; Kristel Van Steen; Kristel Van Steen
Publié dans: Frontiers in microbiology., Numéro 14:1170391, 2023, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2023.1170391