Translational SYStemics: Personalised Medicine at the Interface of Translational Research and Systems Medicine

Información del proyecto

TranSYS

Identificador del acuerdo de subvención: 860895

DOI

10.3030/860895

Proyecto cerrado

Fecha de la firma de la CE 19 Agosto 2019

Fecha de inicio 1 Septiembre 2019

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 916 285,67

Aportación de la UE

€ 3 916 285,67

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

TranSYS guidelines & recommendations for CT design

TranSYS guidelines & recommendations for clinical trials design for Personalized Medicine and targeted drug treatment modalities

TranSYS white paper II

TranSYS white paper II: Road Map to develop an omics data-integrative PGx panel enhancing early molecular diagnosis of patients (WP1) and stratified PM in practice (WP3)

TranSYS white paper I

TranSYS white paper I: data integrative analytic strategies and hybrid approaches, implementations and role in PM

Economic model of the developed and validated preemptive pharmacogenomics genotyping panels

ESR14: Economic model of the developed and validated preemptive pharmacogenomics genotyping panels

Ethics plan and recommendations regarding emerging moral questions in personalized medicine

ESR4: Ethics plan and recommendations regarding emerging moral questions in personalized medicine

Open Science summary of all ETN research results

Open Science summary of all ETN research results via website

Demonstrators, pilots, prototypes (5)

A multi-level data integrative framework and tool for validation, interpretation and translation of multi-level patient subtyping

ESR2: A multi-level data integrative framework and tool for validation, interpretation and translation of multi-level patient subtyping

A multi-omics patient stratification strategy and tool using advanced pattern recognition for PM

ESR3: A multi-omics patient stratification strategy and tool using advanced pattern recognition for PM

User friendly app for LifeLines-Deep participants to consult a personal pharmacogenetic passport

ESR12: User friendly app for LifeLines-Deep participants to consult a personal pharmacogenetic passport

Pipeline for individual-specific network construction and corresponding module detection/comparison schemes

ESR1: Pipeline for individual-specific network construction and corresponding module detection/comparison schemes

Description of decentralized software ecosystem and acquired understanding of clinical trial related blockchain technology

ESR10: Description of decentralized software ecosystem and acquired understanding of clinical trial related blockchain technology

Other (5)

TranSYS School 1

Lead overlooking Body Training Council Natasa Przulj Details Annex 1 Part B Table 22b

Doctoral Schools

ESRs enrolled in doctoral school programmes regulated by M12

TranSYS School 3

Lead overlooking Body: Training Council (Natasa Przulj); Details Annex 1 - Part B - Table 2.2b

TranSYS Flagship conference event

Closing conference

TranSYS School 2

Lead overlooking Body: Training Council (Natasa Przulj); Details Annex 1 - Part B - Table 2.2b

Websites, patent fillings, videos etc. (2)

TranSYS intranet and extranet / SharePoint in place

Website for data sharing internal CO external PU Sharepoint for easy filling of reports and sharing documents within WGs within TranSYS Boards within TranSYS at large

TranSYS recruitment pages online with ESR vacancies posted (recruitment process+gender plan)

Publicaciones

Peer reviewed articles (12)

Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections

Autores: Katz, Sonja; Suijker, Jaco; Hardt, Christopher; Madsen, Martin Bruun; Meij de Vries, Annebeth; Pijpe, Anouk; Skrede, Steinar; Hyldegaard, Ole; Solligård, Erik; Norrby-Teglund, Anna; Saccenti, Edoardo; Martins dos Santos, Vitor A.P.
Publicado en: Int J Med Inform., Edición 167, 2022, ISSN 1386-5056
Editor: Elsevier BV
DOI: 10.1016/j.ijmedinf.2022.104878

Economic evaluation in psychiatric pharmacogenomics: a systematic review

Autores: Kariofyllis Karamperis, Maria Koromina, Panagiotis Papantoniou, Maria Skokou, Filippos Kanellakis, Konstantinos Mitropoulos, Athanassios Vozikis, Daniel J. Müller, George P. Patrinos, Christina Mitropoulou
Publicado en: The Pharmacogenomics Journal, Edición 21/4, 2021, Página(s) 533-541, ISSN 1470-269X
Editor: Nature Publishing Group
DOI: 10.1038/s41397-021-00249-1

Guided extraction of genome-scale metabolic models for the integration and analysis of omics data

Autores: Andrew Walakira, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon
Publicado en: Computational and Structural Biotechnology Journal, Edición 19, 2021, Página(s) 3521-3530, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2021.06.009

Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics

Autores: Maria Koromina, Stefania Koutsilieri, George P. Patrinos
Publicado en: Human Genomics, Edición 14/1, 2020, ISSN 1479-7364
Editor: Springer Nature
DOI: 10.1186/s40246-019-0254-y

Individual-specific networks for prediction modelling – A scoping review of methods

Autores: Gregorich, Mariella; Melograna, Federico; Sunqvist, Martina; Michiels, Stefan; van Steen, Kristel; Heinze, Georg
Publicado en: BMC Med Res Methodol, Edición 22, 2022, Página(s) 62, ISSN 1471-2288
Editor: BioMed Central
DOI: 10.1186/s12874-022-01544-6

Integrative computational modeling to unravel novel potential biomarkers in hepatocellular carcinoma

Autores: Andrew Walakira, Cene Skubic, Nejc Nadižar, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon,
Publicado en: Computers in Biology and Medicine, 2023, ISSN 0010-4825
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.106957

The AIMe registry for artificial intelligence in biomedical research.

Autores: Julian Matschinske; Julian Matschinske; Nicolas Alcaraz; Arriel Benis; Martin Golebiewski; Dominik G. Grimm; Dominik G. Grimm; Lukas Heumos; Tim Kacprowski; Tim Kacprowski; Tim Kacprowski; Olga Lazareva; Markus List; Zakaria Louadi; Zakaria Louadi; Josch Konstantin Pauling; Nico Pfeifer; Richard Röttger; Veit Schwämmle; Gregor Sturm; Alberto Traverso; Kristel Van Steen; Kristel Van Steen; Martie
Publicado en: VOLUME=18;ISSUE=10;STARTPAGE=1128;ENDPAGE=1131;ISSN=1548-7091;TITLE=Nature Methods, Edición 2, 2021, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-021-01241-0

Taking the risk. A systematic review of ethical reasons and moral arguments in the clinical use of polygenic risk scores

Autores: Lara Andreoli, Hilde Peeters, Kristel Van Steen, Kris Dierickx
Publicado en: American Journal of medical genetics, Edición 194 issue 7, 2024, ISSN 1552-4825
Editor: Wiley-Liss Inc
DOI: 10.1002/ajmg.a.63584

Detecting gene–gene interactions from GWAS using diffusion kernel principal components

Autores: Andrew Walakira; Junior Ocira; Diane Duroux; Ramouna Fouladi; Miha Moškon; Damjana Rozman; Kristel Van Steen
Publicado en: BMC Bioinformatics 23, Edición 1, 2022, Página(s) Article number: 57 (2022), ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-022-04580-7

An overview of machine learning methods for monotherapy drug response prediction

Autores: Farzaneh Firoozbakht, Behnam Yousefi, Benno Schwikowski
Publicado en: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Editor: Oxford University Press
DOI: 10.1093/bib/bbab408

PLEX.I: a tool to discover features in multiplex networks that reflect clinical variation

Autores: Behnam Yousefi; Behnam Yousefi; Behnam Yousefi; Farzaneh Firoozbakht; Federico Melograna; Benno Schwikowski; Kristel Van Steen; Kristel Van Steen
Publicado en: Frontiers in Genetics, Edición 3, 2023, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2023.1274637

Capturing the dynamics of microbial interactions through individual-specific networks

Autores: Behnam Yousefi; Behnam Yousefi; Behnam Yousefi; Federico Melograna; Gianluca Galazzo; Niels van Best; Niels van Best; Monique Mommers; John Penders; John Penders; Benno Schwikowski; Kristel Van Steen; Kristel Van Steen
Publicado en: Frontiers in microbiology., Edición 14:1170391, 2023, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2023.1170391