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Heating triggered drug release from nanometric inorganic-metal organic framework composites

Project description

Nanomissiles will target tumours for destruction

Nanotechnology has fostered intensive biomedical research focused on the development of miniaturised drug delivery 'missiles' to treat numerous diseases where they strike. Loaded with highly specific drugs, the nanocarriers are induced to release their payloads only upon locking on the target. Rapid advances have led to the discovery of many types of carriers for drug delivery as well as a myriad of ways to release the drugs, including both externally applied and internally sensed signals. However, many challenges still exist. HeatNMof is training the next generation of materials scientists in nanomedicine to exploit heat-triggered release for delivery of anti-tumour drugs. The network is focusing on one of the most promising classes of carriers, inorganic-metal organic framework (MOF) composites.

Objective

Although recent advances in nanotechnology have provided an excellent platform to revolutionize the domain of health, the efficient and target delivery of many potent drugs in the body still remains an important challenge due to important drawbacks either from the drug (bioavailability, toxicity, etc.) and/or from the nanocarrier (biocompatibility, reproducibility, insufficient targeting). Consequently, there is currently a real demand for drug nanocarriers able to solve these matters for the different administration routes.
HeatNMof project aims to develop smart multifunctional nanocarriers of challenging antitumoral drugs based on versatile highly porous biocompatible nanometric Metal Organic Frameworks, associated with exceptional drug payloads and controlled releases, and photo- and/or magnetic inorganic nanoparticles, providing both a specific control of reactions inside living entities (i.e. heating-triggered drug release) and additional properties such as imaging (magnetic resonance, thermal or optoacoustic imaging) and/ or hyperthermia therapy.
The successful development of this project, involving academic and industrial partners, will contribute to the improvement of the highly societal relevant cancer therapy. This research objective is strongly related with the prime training/networking aim of HeatNMof: to train the next generation of materials scientists in a highly interdisciplinary and intersectorial research environment, such that they can soundly address upcoming challenges concerning nanomedicine, from the development, optimization and (physicochemical and biological) characterization of inorganic and hybrid materials, as well as their interaction with living entities, with a strong focus on drug delivery platforms based on nanomaterials. HeatNMof will train the next generation of material scientists with sound expertise in nanomedicine, highly needed to bring advanced materials as proposed from the bench to society.

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

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Call for proposal

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(opens in new window) H2020-MSCA-ITN-2019

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Coordinator

Fundacion IMDEA Energia
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 529 688,09
Address
AVENIDA RAMON DE LA SAGRA 3
28935 Mostoles Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 529 688,09

Participants (9)

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