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NEUROtransmitter TRANSporters: from single molecules to human pathologies

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Publications

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API.

Author(s): Kornel Ozvoldik; Thomas Stockner; Burkhard Rammner; Elmar Krieger
Published in: Journal of Chemical Information and Modeling, 61, 2021, Page(s) 5293–5303, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.1c00743

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

Author(s): Ralph Gradisch, Dániel Szöllősi, Marco Niello, Erika Lazzarin, Harald H. Sitte, Thomas Stockner
Published in: Journal Of Biological Chemistry, 298, 3, 2022, Page(s) 101613, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101613

High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS

Author(s): Sourav Maity, Gianluca Trinco, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, WAlter H. Roos
Published in: PNAS, No. 6, 2022, ISSN 1091-6490
Publisher: National academy of Science
DOI: 10.1073/pnas.2113927119

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Author(s): Lerner, Eitan; Barth, Anders; Hendrix, Jelle; Ambrose, Benjamin; Birkedal, Victoria; Blanchard, Scott C.; Börner, Richard; Chung, Hoi Sung; Cordes, Thorben; Craggs, Timothy D.; Deniz, Ashok A.; Diao, Jiajia; Fei, Jingyi; Gonzalez, Ruben L.; Gopich, Irina V.; Ha, Taekjip; Hanke, Christian A.; Haran, Gilad; Hatzakis, Nikos S.; Hohng, Sungchul; Hong, Seok Cheol; Hugel, Thorsten; Ingargiola, Antonino
Published in: elife, 10, 2021, Page(s) e60416, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60416

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Author(s): Per Plenge, Dongxue Yang, Kristine Salamon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Published in: Nature Communications, Nature Communications volume 12, Article number: 5063, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25363-3

SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1

Author(s): Andre Bazzone, Alexander Körner, Melanie Meincke, Manan Bhatt, Srujan Dondapati, Maria Barthmes, Stefan Kubick, Niels Fertig
Published in: Biosensors and Bioelectronics, Elsevier, Number 197, 2021, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2021.113763

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

Author(s): Nadal-Gratacós, Nuria; Alberto-Silva, Ana Sofia; Rodríguez-Soler, Míriam; Urquizu, Edurne; Espinosa-Velasco, Maria; Jäntsch, Kathrin; Holy, Marion; Batllori, Xavier; Berzosa, Xavier; Pubill, David; Camarasa, Jordi; Sitte, Harald H.; Escubedo, Elena; López-Arnau, Raúl
Published in: Frontiers in Pharmacology, Oktober 2021, Volume 12, Article 749429, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.749429