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NEUROtransmitter TRANSporters: from single molecules to human pathologies

Publications

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Author(s): Dino Luethi; Julian Maier; Deborah Rudin; Dániel Szöllősi; Thomas J. F. Angenoorth; Stevan Stankovic; Matthias Schittmayer; Isabella Burger; Jae-Won Yang; Kathrin Jaentsch; Marion Holy; Anand Kant Das; Mario Brameshuber; Gisela Andrea Camacho-Hernandez; Andrea Casiraghi; Amy Hauck Newman; Oliver Kudlacek; Ruth Birner-Gruenberger; Thomas Stockner; Gerhard J. Schütz; Harald H. Sitte
Published in: Communications Biology, Issue 5, 1259, 2022, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-022-04210-1

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API.

Author(s): Kornel Ozvoldik; Thomas Stockner; Burkhard Rammner; Elmar Krieger
Published in: Journal of Chemical Information and Modeling, Issue 61, 2021, Page(s) 5293–5303, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.1c00743

Structural basis of organic cation transporter-3 inhibition

Author(s): Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; Chao Qi; Marion Holy; Kathrin Jäntsch; Oliver Kudlacek; Klaus Schicker; Thomas Werge; Ulrik Gether; Thomas Stockner; Volodymyr M. Korkhov; Harald H. Sitte
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34284-8

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

Author(s): Ralph Gradisch, Dániel Szöllősi, Marco Niello, Erika Lazzarin, Harald H. Sitte, Thomas Stockner
Published in: Journal Of Biological Chemistry, Issue 298, 3, 2022, Page(s) 101613, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101613

High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS

Author(s): Sourav Maity, Gianluca Trinco, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, WAlter H. Roos
Published in: PNAS, Issue No. 6, 2022, ISSN 1091-6490
Publisher: National academy of Science
DOI: 10.1073/pnas.2113927119

The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research

Author(s): Manan Bhatt; Angela Di Iacovo; Tiziana Romanazzi; Cristina Roseti; Raffaella Cinquetti; Elena Bossi
Published in: Membranes, Issue 20770375, 2022, Page(s) membranes12100927, ISSN 2077-0375
Publisher: Molecular Diversity Preservation International
DOI: 10.3390/membranes12100927

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Author(s): Lerner, Eitan; Barth, Anders; Hendrix, Jelle; Ambrose, Benjamin; Birkedal, Victoria; Blanchard, Scott C.; Börner, Richard; Chung, Hoi Sung; Cordes, Thorben; Craggs, Timothy D.; Deniz, Ashok A.; Diao, Jiajia; Fei, Jingyi; Gonzalez, Ruben L.; Gopich, Irina V.; Ha, Taekjip; Hanke, Christian A.; Haran, Gilad; Hatzakis, Nikos S.; Hohng, Sungchul; Hong, Seok Cheol; Hugel, Thorsten; Ingargiola, Antonino
Published in: elife, Issue 10, 2021, Page(s) e60416, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60416

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Author(s): Per Plenge, Dongxue Yang, Kristine Salamon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Published in: Nature Communications, Issue Nature Communications volume 12, Article number: 5063, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25363-3

SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1

Author(s): Andre Bazzone, Alexander Körner, Melanie Meincke, Manan Bhatt, Srujan Dondapati, Maria Barthmes, Stefan Kubick, Niels Fertig
Published in: Biosensors and Bioelectronics, Elsevier, Issue Vol. 197, 2022, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2021.113763

Bile acid interactions with neurotransmitter transporters

Author(s): Tiziana Romanazzi; Daniele Zanella; Manan Bhatt; Angela Di Iacovo; Aurelio Galli; Elena Bossi
Published in: Frontiers in Cellular Neuroscience, Issue Vol. 17, 2023, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1161930

SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1

Author(s): Andre Bazzone, Alexander Körner, Melanie Meincke, Manan Bhatt, Srujan Dondapati, Maria Barthmes, Stefan Kubick, Niels Fertig
Published in: Biosensors and Bioelectronics, Elsevier, Issue Number 197, 2021, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2021.113763

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

Author(s): Nadal-Gratacós, Nuria; Alberto-Silva, Ana Sofia; Rodríguez-Soler, Míriam; Urquizu, Edurne; Espinosa-Velasco, Maria; Jäntsch, Kathrin; Holy, Marion; Batllori, Xavier; Berzosa, Xavier; Pubill, David; Camarasa, Jordi; Sitte, Harald H.; Escubedo, Elena; López-Arnau, Raúl
Published in: Frontiers in Pharmacology, Issue Oktober 2021, Volume 12, Article 749429, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.749429

Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

Author(s): Andre Bazzone; Rocco Zerlotti; Maria Barthmes; Niels Fertig
Published in: Frontiers in Physiology, Issue 14, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1058583

Betaine—The dark knight of the brain

Author(s): Manan Bhatt, Angela Di Iacovo, Tiziana Romanazzi, Cristina Roseti, Elena Bossi
Published in: Basic and Clinical Pharmacolgy and Toxicology, Issue 12 issues/year, 2023, ISSN 1742-7843
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/bcpt.13839

Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6

Author(s): Emanuela Colucci; Zaid R. Anshari; Miyer F. Patiño-Ruiz; Mariia Nemchinova; Jacob Whittaker; Dirk J. Slotboom; Albert Guskov
Published in: Nature Communications, Issue 14, 1799, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37503-y

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

Author(s): Manan Bhatt; Laure Gauthier-Manuel; Erika Lazzarin; Rocco Zerlotti; Christine Ziegler; Andre Bazzone; Thomas Stockner; Elena Bossi
Published in: Frontiers in Physiology, Issue 14, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1145973

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