NEUROtransmitter TRANSporters: from single molecules to human pathologies

Project Information

NeuroTrans

Grant agreement ID: 860954

DOI 10.3030/860954

EC signature date 5 February 2020

Start date 1 February 2020

End date 31 July 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 994 422,12

EU contribution € 3 994 422,12

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

Publications

Peer reviewed articles (21)

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Author(s): Dino Luethi; Julian Maier; Deborah Rudin; Dániel Szöllősi; Thomas J. F. Angenoorth; Stevan Stankovic; Matthias Schittmayer; Isabella Burger; Jae-Won Yang; Kathrin Jaentsch; Marion Holy; Anand Kant Das; Mario Brameshuber; Gisela Andrea Camacho-Hernandez; Andrea Casiraghi; Amy Hauck Newman; Oliver Kudlacek; Ruth Birner-Gruenberger; Thomas Stockner; Gerhard J. Schütz; Harald H. Sitte
Published in: Communications Biology, Issue 5, 1259, 2022, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-022-04210-1

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

Author(s): Ana Sofia Alberto-Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte
Published in: Journal of Neurochemistry, Issue Epub ahead of print, 2024, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16149

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

Author(s): Ralph Gradisch; Katharina Schlögl; Erika Lazzarin; Marco Niello; Julian Maier; Felix P. Mayer; Leticia Alves da Silva; Sophie M. C. Skopec; Randy D. Blakely; Harald H. Sitte; Marko D. Mihovilovic; Thomas Stockner
Published in: Nature Communications, Issue Vol 15, Iss 1, Pp 1-15 (2024), 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44637-6

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API.

Author(s): Kornel Ozvoldik; Thomas Stockner; Burkhard Rammner; Elmar Krieger
Published in: Journal of Chemical Information and Modeling, Issue 61, 2021, Page(s) 5293–5303, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.1c00743

Structural basis of organic cation transporter-3 inhibition

Author(s): Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; Chao Qi; Marion Holy; Kathrin Jäntsch; Oliver Kudlacek; Klaus Schicker; Thomas Werge; Ulrik Gether; Thomas Stockner; Volodymyr M. Korkhov; Harald H. Sitte
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34284-8

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

Author(s): Ralph Gradisch, Dániel Szöllősi, Marco Niello, Erika Lazzarin, Harald H. Sitte, Thomas Stockner
Published in: Journal Of Biological Chemistry, Issue 298, 3, 2022, Page(s) 101613, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101613

High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS

Author(s): Sourav Maity, Gianluca Trinco, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, WAlter H. Roos
Published in: PNAS, Issue No. 6, 2022, ISSN 1091-6490
Publisher: National academy of Science
DOI: 10.1073/pnas.2113927119

The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research

Author(s): Manan Bhatt; Angela Di Iacovo; Tiziana Romanazzi; Cristina Roseti; Raffaella Cinquetti; Elena Bossi
Published in: Membranes, Issue 20770375, 2022, Page(s) membranes12100927, ISSN 2077-0375
Publisher: Molecular Diversity Preservation International
DOI: 10.3390/membranes12100927

Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro

Author(s): Francesca R. Brugnoli; Marion Holy; Marco Niello; Julian Maier; Marcus Hanreich; Mario Menzel; Matthias Haberler; Niklas Zulus; Thomas Pickl; Christa Ivanova; Lisa D. Muiznieks; Benjamin Garlan; Harald H. Sitte
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 133 (5), 2023, Page(s) 535-547, ISSN 1742-7835
Publisher: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13940

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Author(s): Lerner, Eitan; Barth, Anders; Hendrix, Jelle; Ambrose, Benjamin; Birkedal, Victoria; Blanchard, Scott C.; Börner, Richard; Chung, Hoi Sung; Cordes, Thorben; Craggs, Timothy D.; Deniz, Ashok A.; Diao, Jiajia; Fei, Jingyi; Gonzalez, Ruben L.; Gopich, Irina V.; Ha, Taekjip; Hanke, Christian A.; Haran, Gilad; Hatzakis, Nikos S.; Hohng, Sungchul; Hong, Seok Cheol; Hugel, Thorsten; Ingargiola, Antonino
Published in: elife, Issue 10, 2021, Page(s) e60416, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60416

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Author(s): Per Plenge, Dongxue Yang, Kristine Salamon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Published in: Nature Communications, Issue Nature Communications volume 12, Article number: 5063, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25363-3

SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1

Author(s): Andre Bazzone, Alexander Körner, Melanie Meincke, Manan Bhatt, Srujan Dondapati, Maria Barthmes, Stefan Kubick, Niels Fertig
Published in: Biosensors and Bioelectronics, Elsevier, Issue Vol. 197, 2022, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2021.113763

Bile acid interactions with neurotransmitter transporters

Author(s): Tiziana Romanazzi; Daniele Zanella; Manan Bhatt; Angela Di Iacovo; Aurelio Galli; Elena Bossi
Published in: Frontiers in Cellular Neuroscience, Issue Vol. 17, 2023, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1161930

Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

Author(s): Manan Bhatt, Erika Lazzarin, Ana Sofia Alberto-Silva, Guido Domingo, Rocco Zerlotti, Ralph Gradisch, Andre Bazzone, Harald H. Sitte, Thomas Stockner, Elena Bossi
Published in: Cellular and Molecular Life Sciences, Issue Volume 81, article number 269, 2024, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-024-05309-w

Free energy profile of the substrate-induced occlusion of the human serotonin transporter

Author(s): Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockner
Published in: Journal of Neurochemistry, Issue Epub ahead of print, 2024, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16061

YASARA Model–Interactive Molecular Modeling from Two Dimensions to Virtual Realities

Author(s): Kornel Ozvoldik; Thomas Stockner; Elmar Krieger
Published in: Journal of Chemical Information and Modeling, Issue 63 (20), 2023, Page(s) 6177-6182, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.3c01136

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

Author(s): Nadal-Gratacós, Nuria; Alberto-Silva, Ana Sofia; Rodríguez-Soler, Míriam; Urquizu, Edurne; Espinosa-Velasco, Maria; Jäntsch, Kathrin; Holy, Marion; Batllori, Xavier; Berzosa, Xavier; Pubill, David; Camarasa, Jordi; Sitte, Harald H.; Escubedo, Elena; López-Arnau, Raúl
Published in: Frontiers in Pharmacology, Issue Oktober 2021, Volume 12, Article 749429, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.749429

Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

Author(s): Andre Bazzone; Rocco Zerlotti; Maria Barthmes; Niels Fertig
Published in: Frontiers in Physiology, Issue 14, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1058583

Betaine—The dark knight of the brain

Author(s): Manan Bhatt, Angela Di Iacovo, Tiziana Romanazzi, Cristina Roseti, Elena Bossi
Published in: Basic and Clinical Pharmacolgy and Toxicology, Issue 12 issues/year, 2023, ISSN 1742-7843
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/bcpt.13839

Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6

Author(s): Emanuela Colucci; Zaid R. Anshari; Miyer F. Patiño-Ruiz; Mariia Nemchinova; Jacob Whittaker; Dirk J. Slotboom; Albert Guskov
Published in: Nature Communications, Issue 14, 1799, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37503-y

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

Author(s): Manan Bhatt; Laure Gauthier-Manuel; Erika Lazzarin; Rocco Zerlotti; Christine Ziegler; Andre Bazzone; Thomas Stockner; Elena Bossi
Published in: Frontiers in Physiology, Issue 14, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1145973