NEUROtransmitter TRANSporters: from single molecules to human pathologies

Informazioni relative al progetto

NeuroTrans

ID dell’accordo di sovvenzione: 860954

DOI

10.3030/860954

Progetto chiuso

Data della firma CE 5 Febbraio 2020

Data di avvio 1 Febbraio 2020

Data di completamento 31 Luglio 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 994 422,12

Contributo UE

€ 3 994 422,12

Coordinato da

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

MOOC online

Contributions of video or other dissemination material by ESRs submitted to online teaching and training resources in the form of a Massive Open Online Course, MOOC, as hosted by FutureLearn. Each ESR contributes to at least one contribution.

Documents, reports (1)

Publication of review articles

Review articles, as joint efforts of small group, submitted to respected journals in the field. Each ESR needs to contribute to at least one review article.

Other (1)

All PhDs Complete

All ESRs have completed their PhD at their respective host universities

Pubblicazioni

Peer reviewed articles (22)

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

Autori: Ana Sofia Alberto-Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte
Pubblicato in: Journal of Neurochemistry, Numero Epub ahead of print, 2024, ISSN 0022-3042
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16149

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

Autori: Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P. Mayer, Leticia Alves da Silva, Sophie M. C. Skopec, Randy D. Blakely, Harald H. Sitte, Marko D. Mihovilovic, Thomas Stockner
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-44637-6

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API.

Autori: Kornel Ozvoldik; Thomas Stockner; Burkhard Rammner; Elmar Krieger
Pubblicato in: Journal of Chemical Information and Modeling, Numero 61, 2021, Pagina/e 5293–5303, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.1c00743

Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6

Autori: Emanuela Colucci, Zaid R. Anshari, Miyer F. Patiño-Ruiz, Mariia Nemchinova, Jacob Whittaker, Dirk J. Slotboom, Albert Guskov
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-37503-y

Structural basis of organic cation transporter-3 inhibition

Autori: Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; Chao Qi; Marion Holy; Kathrin Jäntsch; Oliver Kudlacek; Klaus Schicker; Thomas Werge; Ulrik Gether; Thomas Stockner; Volodymyr M. Korkhov; Harald H. Sitte
Pubblicato in: Nature Communications, Numero 13, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34284-8

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

Autori: Ralph Gradisch, Dániel Szöllősi, Marco Niello, Erika Lazzarin, Harald H. Sitte, Thomas Stockner
Pubblicato in: Journal Of Biological Chemistry, Numero 298, 3, 2022, Pagina/e 101613, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101613

The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research

Autori: Manan Bhatt, Angela Di Iacovo, Tiziana Romanazzi, Cristina Roseti, Raffaella Cinquetti, Elena Bossi
Pubblicato in: Membranes, Numero 12, 2024, Pagina/e 927, ISSN 2077-0375
Editore: Molecular Diversity Preservation International
DOI: 10.3390/membranes12100927

High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS

Autori: Sourav Maity, Gianluca Trinco, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, WAlter H. Roos
Pubblicato in: PNAS, Numero No. 6, 2022, ISSN 1091-6490
Editore: National academy of Science
DOI: 10.1073/pnas.2113927119

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Autori: Lerner, Eitan; Barth, Anders; Hendrix, Jelle; Ambrose, Benjamin; Birkedal, Victoria; Blanchard, Scott C.; Börner, Richard; Chung, Hoi Sung; Cordes, Thorben; Craggs, Timothy D.; Deniz, Ashok A.; Diao, Jiajia; Fei, Jingyi; Gonzalez, Ruben L.; Gopich, Irina V.; Ha, Taekjip; Hanke, Christian A.; Haran, Gilad; Hatzakis, Nikos S.; Hohng, Sungchul; Hong, Seok Cheol; Hugel, Thorsten; Ingargiola, Antonino
Pubblicato in: elife, Numero 10, 2021, Pagina/e e60416, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.60416

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Autori: Per Plenge, Dongxue Yang, Kristine Salamon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Pubblicato in: Nature Communications, Numero Nature Communications volume 12, Article number: 5063, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25363-3

Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro

Autori: Francesca R. Brugnoli, Marion Holy, Marco Niello, Julian Maier, Marcus Hanreich, Mario Menzel, Matthias Haberler, Niklas Zulus, Thomas Pickl, Christa Ivanova, Lisa D. Muiznieks, Benjamin Garlan, Harald H. Sitte
Pubblicato in: Basic & Clinical Pharmacology & Toxicology, Numero 133, 2023, Pagina/e 535-547, ISSN 1742-7835
Editore: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13940

Bile acid interactions with neurotransmitter transporters

Autori: Tiziana Romanazzi; Daniele Zanella; Manan Bhatt; Angela Di Iacovo; Aurelio Galli; Elena Bossi
Pubblicato in: Frontiers in Cellular Neuroscience, Numero Vol. 17, 2023, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1161930

Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

Autori: Manan Bhatt, Erika Lazzarin, Ana Sofia Alberto-Silva, Guido Domingo, Rocco Zerlotti, Ralph Gradisch, Andre Bazzone, Harald H. Sitte, Thomas Stockner, Elena Bossi
Pubblicato in: Cellular and Molecular Life Sciences, Numero Volume 81, article number 269, 2024, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-024-05309-w

Free energy profile of the substrate-induced occlusion of the human serotonin transporter

Autori: Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockner
Pubblicato in: Journal of Neurochemistry, Numero Epub ahead of print, 2024, ISSN 0022-3042
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16061

YASARA Model–Interactive Molecular Modeling from Two Dimensions to Virtual Realities

Autori: Kornel Ozvoldik, Thomas Stockner, Elmar Krieger
Pubblicato in: Journal of Chemical Information and Modeling, Numero 63, 2023, Pagina/e 6177-6182, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.3c01136

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

Autori: Erika Lazzarin, Ralph Gradisch, Sophie MC Skopec, Leticia Alves da Silva, Chiara Sebastianelli-Schoditsch, Dániel Szöllősi, Julian Maier, Sonja Sucic, Marko Roblek, Baruch I Kanner, Harald H Sitte, Thomas Stockner
Pubblicato in: 13:RP93271, Numero 13:RP93271, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.93271.3

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Autori: Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J. F. Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch, Marion Holy, Anand Kant Das, Mario Brameshuber, Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Amy Hauck Newman, Oliver Kudlacek, Ruth Birner-Gruenberger, Thomas Stockner, Gerhard J. Schütz, Harald H. Sitte
Pubblicato in: Communications Biology, Numero 5, 2022, ISSN 2399-3642
Editore: Nature Publishing Group
DOI: 10.1038/s42003-022-04210-1

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

Autori: Nadal-Gratacós, Nuria; Alberto-Silva, Ana Sofia; Rodríguez-Soler, Míriam; Urquizu, Edurne; Espinosa-Velasco, Maria; Jäntsch, Kathrin; Holy, Marion; Batllori, Xavier; Berzosa, Xavier; Pubill, David; Camarasa, Jordi; Sitte, Harald H.; Escubedo, Elena; López-Arnau, Raúl
Pubblicato in: Frontiers in Pharmacology, Numero Oktober 2021, Volume 12, Article 749429, 2021, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.749429

Betaine—The dark knight of the brain

Autori: Manan Bhatt, Angela Di Iacovo, Tiziana Romanazzi, Cristina Roseti, Elena Bossi
Pubblicato in: Basic & Clinical Pharmacology & Toxicology, Numero 133, 2023, Pagina/e 485-495, ISSN 1742-7835
Editore: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13839

Structure of the human dopamine transporter in complex with cocaine

Autori: Jeppe C. Nielsen, Kristine Salomon, Iris E. Kalenderoglou, Sarah Bargmeyer, Tillmann Pape, Azadeh Shahsavar, Claus J. Loland
Pubblicato in: Nature, Numero Epub ahead of print, 2024, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07804-3

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

Autori: Manan Bhatt; Laure Gauthier-Manuel; Erika Lazzarin; Rocco Zerlotti; Christine Ziegler; Andre Bazzone; Thomas Stockner; Elena Bossi
Pubblicato in: Frontiers in Physiology, Numero 14, 2023, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1145973

Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

Autori: Andre Bazzone, Rocco Zerlotti, Maria Barthmes, Niels Fertig
Pubblicato in: Frontiers in Physiology, Numero 14, 2023, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1058583