NEUROtransmitter TRANSporters: from single molecules to human pathologies

Resultado final

Contributions of video or other dissemination material by ESRs submitted to online teaching and training resources in the form of a Massive Open Online Course, MOOC, as hosted by FutureLearn. Each ESR contributes to at least one contribution.

Publication of review articles

Review articles, as joint efforts of small group, submitted to respected journals in the field. Each ESR needs to contribute to at least one review article.

All PhDs Complete

All ESRs have completed their PhD at their respective host universities

Publicaciones

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

Autores: Ana Sofia Alberto-Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte
Publicado en: Journal of Neurochemistry, Edición Epub ahead of print, 2024, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16149

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

Autores: Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P. Mayer, Leticia Alves da Silva, Sophie M. C. Skopec, Randy D. Blakely, Harald H. Sitte, Marko D. Mihovilovic, Thomas Stockner
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-44637-6

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API.

Autores: Kornel Ozvoldik; Thomas Stockner; Burkhard Rammner; Elmar Krieger
Publicado en: Journal of Chemical Information and Modeling, Edición 61, 2021, Página(s) 5293–5303, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.1c00743

Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6

Autores: Emanuela Colucci, Zaid R. Anshari, Miyer F. Patiño-Ruiz, Mariia Nemchinova, Jacob Whittaker, Dirk J. Slotboom, Albert Guskov
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-37503-y

Structural basis of organic cation transporter-3 inhibition

Autores: Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; Chao Qi; Marion Holy; Kathrin Jäntsch; Oliver Kudlacek; Klaus Schicker; Thomas Werge; Ulrik Gether; Thomas Stockner; Volodymyr M. Korkhov; Harald H. Sitte
Publicado en: Nature Communications, Edición 13, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34284-8

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

Autores: Ralph Gradisch, Dániel Szöllősi, Marco Niello, Erika Lazzarin, Harald H. Sitte, Thomas Stockner
Publicado en: Journal Of Biological Chemistry, Edición 298, 3, 2022, Página(s) 101613, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101613

The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research

Autores: Manan Bhatt, Angela Di Iacovo, Tiziana Romanazzi, Cristina Roseti, Raffaella Cinquetti, Elena Bossi
Publicado en: Membranes, Edición 12, 2024, Página(s) 927, ISSN 2077-0375
Editor: Molecular Diversity Preservation International
DOI: 10.3390/membranes12100927

High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS

Autores: Sourav Maity, Gianluca Trinco, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, WAlter H. Roos
Publicado en: PNAS, Edición No. 6, 2022, ISSN 1091-6490
Editor: National academy of Science
DOI: 10.1073/pnas.2113927119

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Autores: Lerner, Eitan; Barth, Anders; Hendrix, Jelle; Ambrose, Benjamin; Birkedal, Victoria; Blanchard, Scott C.; Börner, Richard; Chung, Hoi Sung; Cordes, Thorben; Craggs, Timothy D.; Deniz, Ashok A.; Diao, Jiajia; Fei, Jingyi; Gonzalez, Ruben L.; Gopich, Irina V.; Ha, Taekjip; Hanke, Christian A.; Haran, Gilad; Hatzakis, Nikos S.; Hohng, Sungchul; Hong, Seok Cheol; Hugel, Thorsten; Ingargiola, Antonino
Publicado en: elife, Edición 10, 2021, Página(s) e60416, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.60416

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Autores: Per Plenge, Dongxue Yang, Kristine Salamon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Publicado en: Nature Communications, Edición Nature Communications volume 12, Article number: 5063, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25363-3

Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro

Autores: Francesca R. Brugnoli, Marion Holy, Marco Niello, Julian Maier, Marcus Hanreich, Mario Menzel, Matthias Haberler, Niklas Zulus, Thomas Pickl, Christa Ivanova, Lisa D. Muiznieks, Benjamin Garlan, Harald H. Sitte
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 133, 2023, Página(s) 535-547, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13940

Bile acid interactions with neurotransmitter transporters

Autores: Tiziana Romanazzi; Daniele Zanella; Manan Bhatt; Angela Di Iacovo; Aurelio Galli; Elena Bossi
Publicado en: Frontiers in Cellular Neuroscience, Edición Vol. 17, 2023, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1161930

Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

Autores: Manan Bhatt, Erika Lazzarin, Ana Sofia Alberto-Silva, Guido Domingo, Rocco Zerlotti, Ralph Gradisch, Andre Bazzone, Harald H. Sitte, Thomas Stockner, Elena Bossi
Publicado en: Cellular and Molecular Life Sciences, Edición Volume 81, article number 269, 2024, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-024-05309-w

Free energy profile of the substrate-induced occlusion of the human serotonin transporter

Autores: Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockner
Publicado en: Journal of Neurochemistry, Edición Epub ahead of print, 2024, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16061

YASARA Model–Interactive Molecular Modeling from Two Dimensions to Virtual Realities

Autores: Kornel Ozvoldik, Thomas Stockner, Elmar Krieger
Publicado en: Journal of Chemical Information and Modeling, Edición 63, 2023, Página(s) 6177-6182, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.3c01136

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

Autores: Erika Lazzarin, Ralph Gradisch, Sophie MC Skopec, Leticia Alves da Silva, Chiara Sebastianelli-Schoditsch, Dániel Szöllősi, Julian Maier, Sonja Sucic, Marko Roblek, Baruch I Kanner, Harald H Sitte, Thomas Stockner
Publicado en: 13:RP93271, Edición 13:RP93271, 2024, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.93271.3

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Autores: Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J. F. Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch, Marion Holy, Anand Kant Das, Mario Brameshuber, Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Amy Hauck Newman, Oliver Kudlacek, Ruth Birner-Gruenberger, Thomas Stockner, Gerhard J. Schütz, Harald H. Sitte
Publicado en: Communications Biology, Edición 5, 2022, ISSN 2399-3642
Editor: Nature Publishing Group
DOI: 10.1038/s42003-022-04210-1

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

Autores: Nadal-Gratacós, Nuria; Alberto-Silva, Ana Sofia; Rodríguez-Soler, Míriam; Urquizu, Edurne; Espinosa-Velasco, Maria; Jäntsch, Kathrin; Holy, Marion; Batllori, Xavier; Berzosa, Xavier; Pubill, David; Camarasa, Jordi; Sitte, Harald H.; Escubedo, Elena; López-Arnau, Raúl
Publicado en: Frontiers in Pharmacology, Edición Oktober 2021, Volume 12, Article 749429, 2021, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.749429

Betaine—The dark knight of the brain

Autores: Manan Bhatt, Angela Di Iacovo, Tiziana Romanazzi, Cristina Roseti, Elena Bossi
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 133, 2023, Página(s) 485-495, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.13839

Structure of the human dopamine transporter in complex with cocaine

Autores: Jeppe C. Nielsen, Kristine Salomon, Iris E. Kalenderoglou, Sarah Bargmeyer, Tillmann Pape, Azadeh Shahsavar, Claus J. Loland
Publicado en: Nature, Edición Epub ahead of print, 2024, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-024-07804-3

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

Autores: Manan Bhatt; Laure Gauthier-Manuel; Erika Lazzarin; Rocco Zerlotti; Christine Ziegler; Andre Bazzone; Thomas Stockner; Elena Bossi
Publicado en: Frontiers in Physiology, Edición 14, 2023, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1145973

Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

Autores: Andre Bazzone, Rocco Zerlotti, Maria Barthmes, Niels Fertig
Publicado en: Frontiers in Physiology, Edición 14, 2023, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1058583

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