A nanovaccine Approach for the treatment of Pancreatic Cancer

Deliverables

Project website live
ESR9: Development of nanoliposomes, PLGA and SLNPs with improved capacity and stability to obtain the best pharmacokinetics and immune response for the cancer vaccines.

ESR9 Development of nanoliposomes PLGA and SLNPs with improved capacity and stability to obtain the best pharmacokinetics and immune response for the cancer vaccines

'Train the trainers' programme completed

Train the trainers programme completed

ESR1: Standardisation of protocols and logistics for collecting, storing and transporting both fresh and biobank samples.

ESR1 Standardisation of protocols and logistics for collecting storing and transporting both fresh and biobank samples

ESR11: Deliver bioactive immune proteins, cloned cytokine and chemokine proteins, and mAbs to the proteins and their receptors (porcine model).

ESR11 Deliver bioactive immune proteins cloned cytokine and chemokine proteins and mAbs to the proteins and their receptors porcine model

15 PCDPs approved by SB

Publications

Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice

Author(s): Ozmen Cobanoglu; Lou Delval; Daniele Ferrari; Lucie Deruyter; Séverine Heumel; Isabelle Wolowczuk; Abir Hussein; Ayse Nur Menevse; David Bernard; Philip Beckhove; Frauke Alves; François Trottein
Published in: Aging Cell., Issue 22 (12), 2023, Page(s) pp.e14007, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14007

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Author(s): Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Published in: Biomaterials, Issue 268, 2021, Page(s) 120580, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

KPC-luciferase-expressing cells elicit an anti-tumor immune response in a mouse model of pancreatic cancer

Author(s): Daniele Pereira Ferrari, Fernanda Ramos-Gomes, Frauke Alves, M. Andrea Markus
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-64053-0

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Author(s): Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello and Yasuhiko Tabata
Published in: Polymers 2021, Issue Vol 13, 907, 2021, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym13060907

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Author(s): Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Published in: Cancers, Issue 12/12, 2020, Page(s) 3744, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

Author(s): Menevse, Ayse Nur; Ammer, Laura-Marie; Vollmann-Zwerenz, Arabel; Kupczyk, Marcell; Lorenz, Julia; Weidner, Lorraine; Hussein, Abir; Sax, Julian; Mülbauer, Jasmin; Heuschneider, Nicole; Rohrmus, Celine; Mai, Laura S; Jachnik, Birgit; Stamova, Slava; Volpin, Valentina; Durst, Franziska C; Sorrentino, Antonio; Xydia, Maria; Milenkovic, Vladimir M; Bader, Stefanie; Braun, Frank K; Wetzel, Christian;
Published in: Acta neuropathologica communications., Issue 11(1), 2023, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-023-01550-9

A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models

Author(s): Ajinkya Kulkarni, Nathalia Ferreira, Riccardo Scodellaro, Dolma Choezom, Frauke Alves
Published in: Scientific Data, Issue 11, 2024, ISSN 2052-4463
Publisher: Nature Publishing Group
DOI: 10.1038/s41597-024-03631-3

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy

Author(s): Fanny Guzmán, Adriana Gauna, Tanya Roman, Omar Luna, Claudio Álvarez, Claudia Pareja-Barrueto, Luis Mercado, Fernando Albericio, Constanza Cárdenas
Published in: Molecules, Issue 26/16, 2021, Page(s) 5035, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26165035

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Author(s): Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Published in: Cancer Gene Therapy, 2020, ISSN 0929-1903
Publisher: Nature Publishing Group
DOI: 10.1038/s41417-020-00224-1

The Missing Link: Cre Pigs for Cancer Research

Author(s): Daniela Kalla, Krzysztof Flisikowski, Kaiyuan Yang, Laura Beltran Sangüesa, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Eckhard Wolf, Heiko Lickert, Dieter Saur, Angelika Schnieke, Tatiana Flisikowska
Published in: Frontiers in Oncology, Issue 11, 2021, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.755746

Hierarchical progressive learning of cell identities in single-cell data

Author(s): Lieke Michielsen, Marcel J. T. Reinders, Ahmed Mahfouz
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23196-8

Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

Author(s): Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Valentina Volpin, Franziska Christine Durst, Julian Sax, Maria Xydia, Abir Hussein, Slava Stamova, Steffen Spoerl, Nicole Heuschneider, Jasmin Muehlbauer, Katharina Marlene Jeltsch, Anchana Rathinasamy, Melanie Werner-Klein, Marco Breinig, Damian Mikietyn, Christian Kohler, Isabel Poschke, Sabrina Purr, Olivia Reidell, Catarina Martins Freire
Published in: Journal for immunotherapy of cancer., Issue 10(5), 2022, ISSN 2051-1426
Publisher: BMJ Publishing Group Ltd.
DOI: 10.1136/jitc-2021-004258

SpaGE: Spatial Gene Enhancement using scRNA-seq

Author(s): Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Published in: Nucleic Acids Research, Issue 48/18, 2020, Page(s) e107-e107, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa740

Effects of different immunomodulating liposome-based adjuvants and injection sites on immunogenicity in pigs

Author(s): Evelína Šťastná, Gitte Erbs, Kerstin Skovgaard, Jeanne Toft Jakobsen, Mick Bailey, Gabriel Kristian Pedersen, Gregers Jungersen
Published in: Microbes and infection / Institut Pasteur., Issue 105346, 2024, ISSN 1286-4579
Publisher: Elsevier BV
DOI: 10.1016/j.micinf.2024.105346

An Alternative Technique for Monitoring the Live Interaction of Monocytes and Tumor Cells with Nanoparticles in the Mouse Lung

Author(s): Fernanda Ramos-Gomes, Nathalia Ferreira, Frauke Alves, M Andrea Markus
Published in: Bio-protocol., Issue 12(2), 2022, ISSN 2331-8325
Publisher: Sunnyvale, CA, USA : Bio-protocol LLC, [2011]-
DOI: 10.21769/bioprotoc.4293

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Author(s): Zili Gu, Candido G. Da Silva, Koen Van der Maaden, Ferry Ossendorp, Luis J. Cruz
Published in: Pharmaceutics, Issue 12/11, 2020, Page(s) 1054, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111054

Emerging tools for bioluminescence imaging

Author(s): Giorgia Zambito, Chintan Chawda, Laura Mezzanotte
Published in: Current Opinion in Chemical Biology, Issue 63, 2021, Page(s) 86-94, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2021.02.005

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging

Author(s): Ruben D. Houvast, Mireille Vankemmelbeke, Lindy G. Durrant, Manfred Wuhrer, Victor M. Baart, Peter J. K. Kuppen, Lioe-Fee de Geus-Oei, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Cancers, Issue 12/12, 2020, Page(s) 3870, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123870

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Author(s): Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Published in: International Journal of Molecular Sciences, Issue 22/2, 2021, Page(s) 755, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

Author(s): Hayden Pearce; Wayne Croft; Sandra Margielewska-Davies; Lindsay Lim; Samantha M Nicol; Fouzia Zayou; Daniel Blakeway; Francesca Marcon; Sarah Powell-Brett; Brinder Mahon; Reena Merard; Jianmin Zuo; Gary Middleton; Keith Roberts; Rachel M Brown; Paul Moss
Published in: eLife., Issue 12, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.86125

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Author(s): Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Published in: Molecules, Issue 25/5, 2020, Page(s) 1181, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Published in: Molecules, Issue 25/9, 2020, Page(s) 2219, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Author(s): Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2313, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072313

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
Publisher: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Author(s): Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Pharmaceuticals, Issue 13/8, 2020, Page(s) 172, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

Author(s): Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-020-01522-8

Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release.

Author(s): Srinivasa Rao Manne; Omar Luna; Omar Luna; Gerardo A. Acosta; Gerardo A. Acosta; Miriam Royo; Miriam Royo; Ayman El-Faham; Gyorgy Orosz; Beatriz G. de la Torre; Fernando Albericio; Fernando Albericio; Fernando Albericio
Published in: Organic letters., Issue 23(17), 2021, Page(s) 6900-6904, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.1c02466

Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models

Author(s): Chintan Chawda, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito, Laura Mezzanotte
Published in: Molecular Imaging and Biology, Issue 24, 2024, Page(s) 250-263, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-021-01662-5

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Author(s): Scognamiglio, Iolanda; Cocca, Lorenza; Puoti, Ilaria; Palma, Francesco; Ingenito, Francesco; Quintavalle, Cristina; Affinito, Alessandra; Roscigno, Giuseppina; Nuzzo, Silvia; Chianese, Rosario Vincenzo; Belli, Stefania; Thomas, Guglielmo; Schomann, Timo; Chan, Alan; Stoppelli, Maria Patrizia; Condorelli, Gerolama
Published in: Molecular Therapy: Nucleic Acids, Issue 28, 2022, Page(s) 17-31, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.02.013

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Author(s): Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Published in: International Journal of Molecular Sciences, Issue 22/11, 2021, Page(s) 5730, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Author(s): Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Published in: International Journal of Molecular Sciences, Issue 21/16, 2020, Page(s) 5834, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

Ex vivo Live Cell Imaging of Nanoparticle-Cell Interactions in the Mouse Lung

Author(s): Fernanda Ramos-Gomes, Nathalia Ferreira, Alexander Kraupner, Frauke Alves, M. Andrea Markus
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2020.588922

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer

Author(s): Ana Luiza C. de S.L. Oliveira, Luana Zerillo, Luis J. Cruz, Timo Schomann, Alan B. Chan, Thaís Gomes de Carvalho, Shirley Vitória de P. Souza, Aurigena A. Araújo, Lioe-Fee de Geus-Oei, Raimundo F. de Araújo Júnior
Published in: Materials Science and Engineering: C, Issue 120, 2021, Page(s) 111678, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma

Author(s): Krog, R.T.; Miranda, N.F.C.C. de; Vahrmeijer, A.L.; Kooreman, N.G.
Published in: Cancer, Issue 13(22), 5789;, 2021, Page(s) 5789, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225789

Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging

Author(s): Markus, M. Andrea; Ferrari, Daniele P.; Alves, Frauke; Ramos-Gomes, Fernanda
Published in: Biomedical Optics Express, Issue 14(8), 2023, Page(s) 3988–4002, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.488453

Untangling biological factors influencing trajectory inference from single cell data

Author(s): Mohammed Charrout, Marcel J T Reinders, Ahmed Mahfouz
Published in: NAR Genomics and Bioinformatics, Issue 2/3, 2020, Page(s) lqaa053, ISSN 2631-9268
Publisher: Oxford Academic
DOI: 10.1093/nargab/lqaa053

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Author(s): Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Published in: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Author(s): Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Published in: Molecules, Issue 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

SCHNEL: scalable clustering of high dimensional single-cell data

Author(s): Tamim Abdelaal, Paul de Raadt, Boudewijn P F Lelieveldt, Marcel J T Reinders, Ahmed Mahfouz
Published in: Bioinformatics, Issue 36/Supplement_2, 2020, Page(s) i849-i856, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btaa816

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