A nanovaccine Approach for the treatment of Pancreatic Cancer

Risultati finali

Project website live
ESR9: Development of nanoliposomes, PLGA and SLNPs with improved capacity and stability to obtain the best pharmacokinetics and immune response for the cancer vaccines.

ESR9 Development of nanoliposomes PLGA and SLNPs with improved capacity and stability to obtain the best pharmacokinetics and immune response for the cancer vaccines

'Train the trainers' programme completed

Train the trainers programme completed

ESR1: Standardisation of protocols and logistics for collecting, storing and transporting both fresh and biobank samples.

ESR1 Standardisation of protocols and logistics for collecting storing and transporting both fresh and biobank samples

ESR11: Deliver bioactive immune proteins, cloned cytokine and chemokine proteins, and mAbs to the proteins and their receptors (porcine model).

ESR11 Deliver bioactive immune proteins cloned cytokine and chemokine proteins and mAbs to the proteins and their receptors porcine model

15 PCDPs approved by SB

Pubblicazioni

Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice

Autori: Ozmen Cobanoglu; Lou Delval; Daniele Ferrari; Lucie Deruyter; Séverine Heumel; Isabelle Wolowczuk; Abir Hussein; Ayse Nur Menevse; David Bernard; Philip Beckhove; Frauke Alves; François Trottein
Pubblicato in: Aging Cell., Numero 22 (12), 2023, Pagina/e pp.e14007, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.14007

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Autori: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Pubblicato in: Biomaterials, Numero 268, 2021, Pagina/e 120580, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autori: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello and Yasuhiko Tabata
Pubblicato in: Polymers 2021, Numero Vol 13, 907, 2021, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym13060907

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Autori: Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3744, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

Autori: Menevse, Ayse Nur; Ammer, Laura-Marie; Vollmann-Zwerenz, Arabel; Kupczyk, Marcell; Lorenz, Julia; Weidner, Lorraine; Hussein, Abir; Sax, Julian; Mülbauer, Jasmin; Heuschneider, Nicole; Rohrmus, Celine; Mai, Laura S; Jachnik, Birgit; Stamova, Slava; Volpin, Valentina; Durst, Franziska C; Sorrentino, Antonio; Xydia, Maria; Milenkovic, Vladimir M; Bader, Stefanie; Braun, Frank K; Wetzel, Christian;
Pubblicato in: Acta neuropathologica communications., Numero 11(1), 2023, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-023-01550-9

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy

Autori: Fanny Guzmán, Adriana Gauna, Tanya Roman, Omar Luna, Claudio Álvarez, Claudia Pareja-Barrueto, Luis Mercado, Fernando Albericio, Constanza Cárdenas
Pubblicato in: Molecules, Numero 26/16, 2021, Pagina/e 5035, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26165035

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Autori: Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Pubblicato in: Cancer Gene Therapy, 2020, ISSN 0929-1903
Editore: Nature Publishing Group
DOI: 10.1038/s41417-020-00224-1

The Missing Link: Cre Pigs for Cancer Research

Autori: Daniela Kalla, Krzysztof Flisikowski, Kaiyuan Yang, Laura Beltran Sangüesa, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Eckhard Wolf, Heiko Lickert, Dieter Saur, Angelika Schnieke, Tatiana Flisikowska
Pubblicato in: Frontiers in Oncology, Numero 11, 2021, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.755746

Hierarchical progressive learning of cell identities in single-cell data

Autori: Lieke Michielsen, Marcel J. T. Reinders, Ahmed Mahfouz
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23196-8

Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

Autori: Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Valentina Volpin, Franziska Christine Durst, Julian Sax, Maria Xydia, Abir Hussein, Slava Stamova, Steffen Spoerl, Nicole Heuschneider, Jasmin Muehlbauer, Katharina Marlene Jeltsch, Anchana Rathinasamy, Melanie Werner-Klein, Marco Breinig, Damian Mikietyn, Christian Kohler, Isabel Poschke, Sabrina Purr, Olivia Reidell, Catarina Martins Freire
Pubblicato in: Journal for immunotherapy of cancer., Numero 10(5), 2022, ISSN 2051-1426
Editore: BMJ Publishing Group Ltd.
DOI: 10.1136/jitc-2021-004258

SpaGE: Spatial Gene Enhancement using scRNA-seq

Autori: Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Pubblicato in: Nucleic Acids Research, Numero 48/18, 2020, Pagina/e e107-e107, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa740

Effects of different immunomodulating liposome-based adjuvants and injection sites on immunogenicity in pigs

Autori: Evelína Šťastná, Gitte Erbs, Kerstin Skovgaard, Jeanne Toft Jakobsen, Mick Bailey, Gabriel Kristian Pedersen, Gregers Jungersen
Pubblicato in: Microbes and infection / Institut Pasteur., Numero 105346, 2024, ISSN 1286-4579
Editore: Elsevier BV
DOI: 10.1016/j.micinf.2024.105346

An Alternative Technique for Monitoring the Live Interaction of Monocytes and Tumor Cells with Nanoparticles in the Mouse Lung

Autori: Fernanda Ramos-Gomes, Nathalia Ferreira, Frauke Alves, M Andrea Markus
Pubblicato in: Bio-protocol., Numero 12(2), 2022, ISSN 2331-8325
Editore: Sunnyvale, CA, USA : Bio-protocol LLC, [2011]-
DOI: 10.21769/bioprotoc.4293

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Autori: Zili Gu, Candido G. Da Silva, Koen Van der Maaden, Ferry Ossendorp, Luis J. Cruz
Pubblicato in: Pharmaceutics, Numero 12/11, 2020, Pagina/e 1054, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111054

Emerging tools for bioluminescence imaging

Autori: Giorgia Zambito, Chintan Chawda, Laura Mezzanotte
Pubblicato in: Current Opinion in Chemical Biology, Numero 63, 2021, Pagina/e 86-94, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2021.02.005

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging

Autori: Ruben D. Houvast, Mireille Vankemmelbeke, Lindy G. Durrant, Manfred Wuhrer, Victor M. Baart, Peter J. K. Kuppen, Lioe-Fee de Geus-Oei, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3870, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123870

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Autori: Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Pubblicato in: International Journal of Molecular Sciences, Numero 22/2, 2021, Pagina/e 755, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

Autori: Hayden Pearce; Wayne Croft; Sandra Margielewska-Davies; Lindsay Lim; Samantha M Nicol; Fouzia Zayou; Daniel Blakeway; Francesca Marcon; Sarah Powell-Brett; Brinder Mahon; Reena Merard; Jianmin Zuo; Gary Middleton; Keith Roberts; Rachel M Brown; Paul Moss
Pubblicato in: eLife., Numero 12, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.86125

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Autori: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Pubblicato in: Molecules, Numero 25/5, 2020, Pagina/e 1181, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autori: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Pubblicato in: Molecules, Numero 25/9, 2020, Pagina/e 2219, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Autori: Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Pubblicato in: International Journal of Molecular Sciences, Numero 21/7, 2020, Pagina/e 2313, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072313

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autori: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, ISSN 2296-2646
Editore: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Autori: Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Pubblicato in: Pharmaceuticals, Numero 13/8, 2020, Pagina/e 172, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

Autori: Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Pubblicato in: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Editore: Elsevier BV
DOI: 10.1007/s11307-020-01522-8

Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release.

Autori: Srinivasa Rao Manne; Omar Luna; Omar Luna; Gerardo A. Acosta; Gerardo A. Acosta; Miriam Royo; Miriam Royo; Ayman El-Faham; Gyorgy Orosz; Beatriz G. de la Torre; Fernando Albericio; Fernando Albericio; Fernando Albericio
Pubblicato in: Organic letters., Numero 23(17), 2021, Pagina/e 6900-6904, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.1c02466

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Autori: Scognamiglio, Iolanda; Cocca, Lorenza; Puoti, Ilaria; Palma, Francesco; Ingenito, Francesco; Quintavalle, Cristina; Affinito, Alessandra; Roscigno, Giuseppina; Nuzzo, Silvia; Chianese, Rosario Vincenzo; Belli, Stefania; Thomas, Guglielmo; Schomann, Timo; Chan, Alan; Stoppelli, Maria Patrizia; Condorelli, Gerolama
Pubblicato in: Molecular Therapy: Nucleic Acids, Numero 28, 2022, Pagina/e 17-31, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.02.013

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Autori: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Pubblicato in: International Journal of Molecular Sciences, Numero 22/11, 2021, Pagina/e 5730, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Autori: Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Pubblicato in: International Journal of Molecular Sciences, Numero 21/16, 2020, Pagina/e 5834, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

Ex vivo Live Cell Imaging of Nanoparticle-Cell Interactions in the Mouse Lung

Autori: Fernanda Ramos-Gomes, Nathalia Ferreira, Alexander Kraupner, Frauke Alves, M. Andrea Markus
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2020.588922

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer

Autori: Ana Luiza C. de S.L. Oliveira, Luana Zerillo, Luis J. Cruz, Timo Schomann, Alan B. Chan, Thaís Gomes de Carvalho, Shirley Vitória de P. Souza, Aurigena A. Araújo, Lioe-Fee de Geus-Oei, Raimundo F. de Araújo Júnior
Pubblicato in: Materials Science and Engineering: C, Numero 120, 2021, Pagina/e 111678, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma

Autori: Krog, R.T.; Miranda, N.F.C.C. de; Vahrmeijer, A.L.; Kooreman, N.G.
Pubblicato in: Cancer, Numero 13(22), 5789;, 2021, Pagina/e 5789, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225789

Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging

Autori: Markus, M. Andrea; Ferrari, Daniele P.; Alves, Frauke; Ramos-Gomes, Fernanda
Pubblicato in: Biomedical Optics Express, Numero 14(8), 2023, Pagina/e 3988–4002, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.488453

Untangling biological factors influencing trajectory inference from single cell data

Autori: Mohammed Charrout, Marcel J T Reinders, Ahmed Mahfouz
Pubblicato in: NAR Genomics and Bioinformatics, Numero 2/3, 2020, Pagina/e lqaa053, ISSN 2631-9268
Editore: Oxford Academic
DOI: 10.1093/nargab/lqaa053

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Autori: Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Pubblicato in: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Autori: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Pubblicato in: Molecules, Numero 26/11, 2021, Pagina/e 3272, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

SCHNEL: scalable clustering of high dimensional single-cell data

Autori: Tamim Abdelaal, Paul de Raadt, Boudewijn P F Lelieveldt, Marcel J T Reinders, Ahmed Mahfouz
Pubblicato in: Bioinformatics, Numero 36/Supplement_2, 2020, Pagina/e i849-i856, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btaa816

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