A nanovaccine Approach for the treatment of Pancreatic Cancer

Informacje na temat projektu

PAVE

Identyfikator umowy o grant: 861190

DOI

10.3030/861190

Projekt został zamknięty

Data podpisania przez KE 12 Września 2019

Data rozpoczęcia 1 Października 2019

Data zakończenia 31 Marca 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 4 023 616,68

Wkład UE

€ 4 023 616,68

Koordynowany przez

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (22)

Project website live
Methods for visual and quantitative analysis of immune responses.
ESR13: The induction of antigen specific human T cells by the selected nanovaccine formulations.
ESR9: Development of nanoliposomes, PLGA and SLNPs with improved capacity and stability to obtain the best pharmacokinetics and immune response for the cancer vaccines.

ESR9 Development of nanoliposomes PLGA and SLNPs with improved capacity and stability to obtain the best pharmacokinetics and immune response for the cancer vaccines

ESR10: NP functionalization: an optimised combination of encapsulated and surface conjugated components to induce DC stimulation.
Public engagement activities completed, and report shared
'Train the trainers' programme completed

Train the trainers programme completed

Show immune cell and pathway differences in the TME both before and after its disruption in order to identify translational biomarkers.
ESR2: State-of-the-art pCLE single cell resolution imaging, together with target-specific fluorescent probes, to study PDAC carcinogenesis.
Methods for automatic partitioning of high-dimensional CYTOF2 data into immune cell lineages generalised across immune panels.
ESR1: Standardisation of protocols and logistics for collecting, storing and transporting both fresh and biobank samples.

ESR1 Standardisation of protocols and logistics for collecting storing and transporting both fresh and biobank samples

ESR14: Evaluation of the protective capacity of the desired nanovaccine formulations via in vivo T cell proliferation studies.
ESR11: Deliver bioactive immune proteins, cloned cytokine and chemokine proteins, and mAbs to the proteins and their receptors (porcine model).

ESR11 Deliver bioactive immune proteins cloned cytokine and chemokine proteins and mAbs to the proteins and their receptors porcine model

Project publications including review articles written by ESRs
ESR7: Development of nanovaccine-based strategies to induce anti-tumor responses in the aged population
ESR3: Selection of PDAC-associated immunogenic antigens in mouse, human and porcine systems.

ESR3: Selection of PDAC–associated immunogenic antigens in mouse, human and porcine systems.

ESR8: T cell specific reporter system for the pig for optoacoustic/optical visualisation of proliferation and trafficking of T cells.
ESR1: Accurately differentiate cancerous and pre-cancerous changes in tissue as well as characterise cells from the tumour / stromal interface.
ESR15: Determination of specific CD4+-, CD8+- and Treg-responses in healthy and tumour bearing pigs for each nanovaccine formulation.
ESR6: Development of a pig expressing PDX1-Cre and establishment of triple transgenic KRASG12D/TP53R167H/PDX1-Cre pigs.
ESR12: Identified vaccine formulations in their ability to increase the co-stimulatory capacity of DCs in human, murine and porcine systems.
ESR4: A platform of immune components, including synthetic epitopes, ready for incorporation in WP5.

Other (1)

15 PCDPs approved by SB

Open Research Data Pilot (1)

A data management plan

A data management plan submitted to REA

Publikacje

Peer reviewed articles (42)

Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice

Autorzy: Ozmen Cobanoglu; Lou Delval; Daniele Ferrari; Lucie Deruyter; Séverine Heumel; Isabelle Wolowczuk; Abir Hussein; Ayse Nur Menevse; David Bernard; Philip Beckhove; Frauke Alves; François Trottein
Opublikowane w: Aging Cell., Numer 22 (12), 2023, Strona(/y) pp.e14007, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.14007

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Autorzy: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Opublikowane w: Biomaterials, Numer 268, 2021, Strona(/y) 120580, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

KPC-luciferase-expressing cells elicit an anti-tumor immune response in a mouse model of pancreatic cancer

Autorzy: Daniele Pereira Ferrari, Fernanda Ramos-Gomes, Frauke Alves, M. Andrea Markus
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-024-64053-0

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autorzy: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello and Yasuhiko Tabata
Opublikowane w: Polymers 2021, Numer Vol 13, 907, 2021, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym13060907

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Autorzy: Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Opublikowane w: Cancers, Numer 12/12, 2020, Strona(/y) 3744, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

Autorzy: Menevse, Ayse Nur; Ammer, Laura-Marie; Vollmann-Zwerenz, Arabel; Kupczyk, Marcell; Lorenz, Julia; Weidner, Lorraine; Hussein, Abir; Sax, Julian; Mülbauer, Jasmin; Heuschneider, Nicole; Rohrmus, Celine; Mai, Laura S; Jachnik, Birgit; Stamova, Slava; Volpin, Valentina; Durst, Franziska C; Sorrentino, Antonio; Xydia, Maria; Milenkovic, Vladimir M; Bader, Stefanie; Braun, Frank K; Wetzel, Christian;
Opublikowane w: Acta neuropathologica communications., Numer 11(1), 2023, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-023-01550-9

A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models

Autorzy: Ajinkya Kulkarni, Nathalia Ferreira, Riccardo Scodellaro, Dolma Choezom, Frauke Alves
Opublikowane w: Scientific Data, Numer 11, 2024, ISSN 2052-4463
Wydawca: Nature Publishing Group
DOI: 10.1038/s41597-024-03631-3

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy

Autorzy: Fanny Guzmán, Adriana Gauna, Tanya Roman, Omar Luna, Claudio Álvarez, Claudia Pareja-Barrueto, Luis Mercado, Fernando Albericio, Constanza Cárdenas
Opublikowane w: Molecules, Numer 26/16, 2021, Strona(/y) 5035, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26165035

Benchmarking variational AutoEncoders on cancer transcriptomics data

Autorzy: Mostafa Eltager, Tamim Abdelaal, Mohammed Charrout, Ahmed Mahfouz, Marcel J. T. Reinders, Stavros Makrodimitris
Opublikowane w: Plos One, 2023, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0292126

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Autorzy: Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Opublikowane w: Cancer Gene Therapy, 2020, ISSN 0929-1903
Wydawca: Nature Publishing Group
DOI: 10.1038/s41417-020-00224-1

The Missing Link: Cre Pigs for Cancer Research

Autorzy: Daniela Kalla, Krzysztof Flisikowski, Kaiyuan Yang, Laura Beltran Sangüesa, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Eckhard Wolf, Heiko Lickert, Dieter Saur, Angelika Schnieke, Tatiana Flisikowska
Opublikowane w: Frontiers in Oncology, Numer 11, 2021, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.755746

Hierarchical progressive learning of cell identities in single-cell data

Autorzy: Lieke Michielsen, Marcel J. T. Reinders, Ahmed Mahfouz
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23196-8

Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

Autorzy: Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Valentina Volpin, Franziska Christine Durst, Julian Sax, Maria Xydia, Abir Hussein, Slava Stamova, Steffen Spoerl, Nicole Heuschneider, Jasmin Muehlbauer, Katharina Marlene Jeltsch, Anchana Rathinasamy, Melanie Werner-Klein, Marco Breinig, Damian Mikietyn, Christian Kohler, Isabel Poschke, Sabrina Purr, Olivia Reidell, Catarina Martins Freire
Opublikowane w: Journal for immunotherapy of cancer., Numer 10(5), 2022, ISSN 2051-1426
Wydawca: BMJ Publishing Group Ltd.
DOI: 10.1136/jitc-2021-004258

SpaGE: Spatial Gene Enhancement using scRNA-seq

Autorzy: Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Opublikowane w: Nucleic Acids Research, Numer 48/18, 2020, Strona(/y) e107-e107, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkaa740

Effects of different immunomodulating liposome-based adjuvants and injection sites on immunogenicity in pigs

Autorzy: Evelína Šťastná, Gitte Erbs, Kerstin Skovgaard, Jeanne Toft Jakobsen, Mick Bailey, Gabriel Kristian Pedersen, Gregers Jungersen
Opublikowane w: Microbes and infection / Institut Pasteur., Numer 105346, 2024, ISSN 1286-4579
Wydawca: Elsevier BV
DOI: 10.1016/j.micinf.2024.105346

An Alternative Technique for Monitoring the Live Interaction of Monocytes and Tumor Cells with Nanoparticles in the Mouse Lung

Autorzy: Fernanda Ramos-Gomes, Nathalia Ferreira, Frauke Alves, M Andrea Markus
Opublikowane w: Bio-protocol., Numer 12(2), 2022, ISSN 2331-8325
Wydawca: Sunnyvale, CA, USA : Bio-protocol LLC, [2011]-
DOI: 10.21769/bioprotoc.4293

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Autorzy: Zili Gu, Candido G. Da Silva, Koen Van der Maaden, Ferry Ossendorp, Luis J. Cruz
Opublikowane w: Pharmaceutics, Numer 12/11, 2020, Strona(/y) 1054, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111054

Emerging tools for bioluminescence imaging

Autorzy: Giorgia Zambito, Chintan Chawda, Laura Mezzanotte
Opublikowane w: Current Opinion in Chemical Biology, Numer 63, 2021, Strona(/y) 86-94, ISSN 1367-5931
Wydawca: Elsevier BV
DOI: 10.1016/j.cbpa.2021.02.005

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging

Autorzy: Ruben D. Houvast, Mireille Vankemmelbeke, Lindy G. Durrant, Manfred Wuhrer, Victor M. Baart, Peter J. K. Kuppen, Lioe-Fee de Geus-Oei, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Opublikowane w: Cancers, Numer 12/12, 2020, Strona(/y) 3870, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123870

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Autorzy: Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Opublikowane w: International Journal of Molecular Sciences, Numer 22/2, 2021, Strona(/y) 755, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data

Autorzy: Nathalia Ferreira, Ajinkya Kulkarni, David Agorku, Teona Midelashvili, Olaf Hardt, Tobias J. Legler, Philipp Ströbel, Lena-Christin Conradi, Frauke Alves, Fernanda Ramos-Gomes, M. Andrea Markus
Opublikowane w: Cellular Oncology, 2024, ISSN 2211-3428
Wydawca: Springer Verlag
DOI: 10.1007/s13402-024-00958-2

Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

Autorzy: Hayden Pearce; Wayne Croft; Sandra Margielewska-Davies; Lindsay Lim; Samantha M Nicol; Fouzia Zayou; Daniel Blakeway; Francesca Marcon; Sarah Powell-Brett; Brinder Mahon; Reena Merard; Jianmin Zuo; Gary Middleton; Keith Roberts; Rachel M Brown; Paul Moss
Opublikowane w: eLife., Numer 12, 2023, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.86125

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Autorzy: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Opublikowane w: Molecules, Numer 25/5, 2020, Strona(/y) 1181, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autorzy: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Opublikowane w: Molecules, Numer 25/9, 2020, Strona(/y) 2219, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Autorzy: Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Opublikowane w: International Journal of Molecular Sciences, Numer 21/7, 2020, Strona(/y) 2313, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072313

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autorzy: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Opublikowane w: Frontiers in Chemistry, Numer 8, 2020, ISSN 2296-2646
Wydawca: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Autorzy: Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Opublikowane w: Pharmaceuticals, Numer 13/8, 2020, Strona(/y) 172, ISSN 1424-8247
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

Autorzy: Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Opublikowane w: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Wydawca: Elsevier BV
DOI: 10.1007/s11307-020-01522-8

Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release.

Autorzy: Srinivasa Rao Manne; Omar Luna; Omar Luna; Gerardo A. Acosta; Gerardo A. Acosta; Miriam Royo; Miriam Royo; Ayman El-Faham; Gyorgy Orosz; Beatriz G. de la Torre; Fernando Albericio; Fernando Albericio; Fernando Albericio
Opublikowane w: Organic letters., Numer 23(17), 2021, Strona(/y) 6900-6904, ISSN 1523-7060
Wydawca: American Chemical Society
DOI: 10.1021/acs.orglett.1c02466

Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models

Autorzy: Chintan Chawda, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito, Laura Mezzanotte
Opublikowane w: Molecular Imaging and Biology, Numer 24, 2024, Strona(/y) 250-263, ISSN 1536-1632
Wydawca: Elsevier BV
DOI: 10.1007/s11307-021-01662-5

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Autorzy: Scognamiglio, Iolanda; Cocca, Lorenza; Puoti, Ilaria; Palma, Francesco; Ingenito, Francesco; Quintavalle, Cristina; Affinito, Alessandra; Roscigno, Giuseppina; Nuzzo, Silvia; Chianese, Rosario Vincenzo; Belli, Stefania; Thomas, Guglielmo; Schomann, Timo; Chan, Alan; Stoppelli, Maria Patrizia; Condorelli, Gerolama
Opublikowane w: Molecular Therapy: Nucleic Acids, Numer 28, 2022, Strona(/y) 17-31, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.02.013

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Autorzy: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Opublikowane w: International Journal of Molecular Sciences, Numer 22/11, 2021, Strona(/y) 5730, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Autorzy: Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Opublikowane w: International Journal of Molecular Sciences, Numer 21/16, 2020, Strona(/y) 5834, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

Ex vivo Live Cell Imaging of Nanoparticle-Cell Interactions in the Mouse Lung

Autorzy: Fernanda Ramos-Gomes, Nathalia Ferreira, Alexander Kraupner, Frauke Alves, M. Andrea Markus
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 8, 2020, ISSN 2296-4185
Wydawca: Frontiers Media SA
DOI: 10.3389/fbioe.2020.588922

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer

Autorzy: Ana Luiza C. de S.L. Oliveira, Luana Zerillo, Luis J. Cruz, Timo Schomann, Alan B. Chan, Thaís Gomes de Carvalho, Shirley Vitória de P. Souza, Aurigena A. Araújo, Lioe-Fee de Geus-Oei, Raimundo F. de Araújo Júnior
Opublikowane w: Materials Science and Engineering: C, Numer 120, 2021, Strona(/y) 111678, ISSN 0928-4931
Wydawca: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma

Autorzy: Krog, R.T.; Miranda, N.F.C.C. de; Vahrmeijer, A.L.; Kooreman, N.G.
Opublikowane w: Cancer, Numer 13(22), 5789;, 2021, Strona(/y) 5789, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225789

Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging

Autorzy: Markus, M. Andrea; Ferrari, Daniele P.; Alves, Frauke; Ramos-Gomes, Fernanda
Opublikowane w: Biomedical Optics Express, Numer 14(8), 2023, Strona(/y) 3988–4002, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.488453

Untangling biological factors influencing trajectory inference from single cell data

Autorzy: Mohammed Charrout, Marcel J T Reinders, Ahmed Mahfouz
Opublikowane w: NAR Genomics and Bioinformatics, Numer 2/3, 2020, Strona(/y) lqaa053, ISSN 2631-9268
Wydawca: Oxford Academic
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Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Autorzy: Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Opublikowane w: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

scMoC: single-cell multi-omics clustering

Autorzy: Mostafa Eltager, Tamim Abdelaal, Ahmed Mahfouz, Marcel J. T. Reinders
Opublikowane w: Bioinformatics Advances, 2022, ISSN 2635-0041
Wydawca: Oxford University Press
DOI: 10.1093/bioadv/vbac011

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Autorzy: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Opublikowane w: Molecules, Numer 26/11, 2021, Strona(/y) 3272, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

SCHNEL: scalable clustering of high dimensional single-cell data

Autorzy: Tamim Abdelaal, Paul de Raadt, Boudewijn P F Lelieveldt, Marcel J T Reinders, Ahmed Mahfouz
Opublikowane w: Bioinformatics, Numer 36/Supplement_2, 2020, Strona(/y) i849-i856, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btaa816