PancREatic Cancer OrganoiDs rEsearch Network

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Catalogue of stromal and cancer cell-specific genes changed by anti-cancer treatment
Procedures and protocols for establishment of organoid cultures from rare histologies

Procedures and protocols for establishment of organoid cultures from rare histologies in conjunction with WP1

List of metastasis associated genes in GEPOs
Report on a modification of the consensus classifier for use on organoids and knowledge on the corresponding tumour cell biology
Report on functional characterisation of selected stromal and cancer cell-specific genes
Report on genome-scale CIRSPR/Cas9 essentiality screening of 25 cancers to discover vulnerabilities and integration of genomic data
Design of the microfluidics for combinatorial dispensing
Publication of at least 15 high quality manuscripts in scientific journals

Report on publication of at least 15 high quality manuscripts in scientific journals

Report on a rational strategy for combinatorial therapy based on PaCa organoid co-cultures
Report on a metabolomics signature for drug screening
Report on the role of single genes in EMT of PaCa

Internet distribution channels operational
PRECODE website set-up and running

PRECODE website setup and running

Report on 2nd series of activities – Hands-on training – ESR project reports

Report on 2nd series of activities Handson training ESR project reports

Report on 1st series of activities - Teambuilding - Hands-on training

Report on 1st series of activities Teambuilding Handson training

Adoption of a exploitation strategy
Adoption of IP policy

Adoption of IP policy as part of the CA

Distribution of news on internet channels

Distribution of news on internet channels News will be continually distributed through the diverse internet channels at least until month 48

Report on 4th series of activities- Entrepreneurship
Report on 3rd series of activities - ESR transferable skills – IPR – midterm review on ESR projects

Report on 3rd series of activities ESR transferable skills IPR midterm review on ESR projects

Report on 6th series of activities - Review of ESRs success in the job market
Report on 5th series of activities - Final review of ESR progress - career fair

Publications

Targeting Tumor-Stromal Interactions in Pancreatic Cancer: Impact of Collagens and Mechanical Traits

Auteurs: Parniyan Maneshi, James Mason, Mitesh Dongre, Daniel Öhlund
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.787485

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer Growth

Auteurs: Paul Manoukian, Maarten Bijlsma, Hanneke van Laarhoven
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.743907

PDAC as an Immune Evasive Disease: Can 3D Model Systems Aid to Tackle This Clinical Problem?

Auteurs: Shruthi Narayanan, Silve Vicent, Mariano Ponz-Sarvisé
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.787249

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression

Auteurs: Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Publié dans: Nature Communications, Numéro 14, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-40822-9

Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer

Auteurs: Hai Yang, Bin Liu, Dongxue Liu, Zhirong Yang, Shuman Zhang, Pengyan Xu, Yuming Xing, Isabella Kutschick, Susanne Pfeffer, Nathalie Britzen-Laurent, Robert Grützmann, Christian Pilarsky
Publié dans: Cancers, Numéro 14, 2023, Page(s) 3152, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14133152

Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development

Auteurs: Shannon R. Nelson, Chenxi Zhang, Sandra Roche, Fiona O’Neill, Niall Swan, Yonglun Luo, AnneMarie Larkin, John Crown, Naomi Walsh
Publié dans: Scientific Reports, Numéro 10, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-59368-7

Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer

Auteurs: Shuman Zhang, Duo Yun, Hao Yang, Markus Eckstein, Gihan Daw Elbait, Yaxing Zhou, Yanxi Lu, Hai Yang, Jinping Zhang, Isabella Dörflein, Nathalie Britzen-Laurent, Susanne Pfeffer, Marc P. Stemmler, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Hang He, Siyuan Zeng, Bin Lan, Benjamin Frey, Chuanpit Hampel, Eva Lentsch, Paradesi Naidu Gollavilli, Christian Büttner, Arif B. Ekici, Andrew Biankin
Publié dans: Cell Death Discovery, Numéro 10, 2024, ISSN 2058-7716
Éditeur: SpringerNature
DOI: 10.1038/s41420-024-01890-y

Pre-clinical Models of Metastasis in Pancreatic Cancer

Auteurs: Maria Miquel, Shuman Zhang, Christian Pilarsky
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.748631

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

Auteurs: Joscha Griger, Sebastian A. Widholz, Moritz Jesinghaus, Niklas de Andrade Krätzig, Sebastian Lange, Thomas Engleitner, Juan José Montero, Ekaterina Zhigalova, Rupert Öllinger, Veveeyan Suresh, Wiebke Winkler, Svenja Lier, Olga Baranov, Riccardo Trozzo, Najib Ben Khaled, Shounak Chakraborty, Jiakun Yu, Björn Konukiewitz, Katja Steiger, Nicole Pfarr, Ashish Rajput, David Sailer, Gisela Keller, P
Publié dans: Cancer Cell, Numéro 41, 2024, Page(s) 1327-1344.e10, ISSN 1535-6108
Éditeur: Cell Press
DOI: 10.1016/j.ccell.2023.06.001

Editorial: Translational Insights Into Pancreatic Ductal Adenocarcinoma

Auteurs: Maarten F. Bijlsma, Peter J. Bailey, Marc P. Stemmler
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 10, 2022, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2022.875836

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

Auteurs: Mónica P de Andrés, Richard J Jackson, Irene Felipe, Sladjana Zagorac, Christian Pilarsky, Anna Melissa Schlitter, Jaime Martinez de Villareal, Gun Ho Jang, Eithne Costello, Steve Gallinger, Paula Ghaneh, William Greenhalf, Thomas Knösel, Daniel H Palmer, Petra Ruemmele, Wilko Weichert, Markus Buechler, Thilo Hackert, John P Neoptolemos, Faiyaz Notta, Núria Malats, Paola Martinelli, Francisco
Publié dans: Gut, Numéro 72, 2023, Page(s) 535-548, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325803

Loss of FGFR4 promotes the malignant phenotype of PDAC

Auteurs: Sabrina D’Agosto, Francesco Pezzini, Lisa Veghini, Pietro Delfino, Claudia Fiorini, Gael D. Temgue Tane, Anais Del Curatolo, Caterina Vicentini, Giorgia Ferrari, Davide Pasini, Silvia Andreani, Francesca Lupo, Elena Fiorini, Giulia Lorenzon, Rita T. Lawlor, Borislav Rusev, Antonia Malinova, Claudio Luchini, Michele Milella, Elisabetta Sereni, Antonio Pea, Claudio Bassi, Peter Bailey, Aldo Scarpa
Publié dans: Oncogene, Numéro 41, 2022, Page(s) 4371-4384, ISSN 0950-9232
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-022-02432-5

Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

Auteurs: Francesca Lupo, Francesco Pezzini, Davide Pasini, Elena Fiorini, Annalisa Adamo, Lisa Veghini, Michele Bevere, Cristina Frusteri, Pietro Delfino, Sabrina D'agosto, Silvia Andreani, Geny Piro, Antonia Malinova, Tian Wang, Francesco De Sanctis, Rita Teresa Lawlor, Chang-il Hwang, Carmine Carbone, Ivano Amelio, Peter Bailey, Vincenzo Bronte, David Tuveson, Aldo Scarpa, Stefano Ugel, Vincenzo Corbo
Publié dans: Gut, Numéro 73, 2024, Page(s) 1321-1335, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-329807

Microfluidics and Organoids, the Power Couple of Developmental Biology and Oncology Studies

Auteurs: Laura Ann Hetzel, Ahmed Ali, Vincenzo Corbo, Thomas Hankemeier
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, Page(s) 10882, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241310882

Deconstructing Pancreatic Cancer Using Next Generation-Omic Technologies–From Discovery to Knowledge-Guided Platforms for Better Patient Management

Auteurs: Daniel Schreyer, John P. Neoptolemos, Simon T. Barry, Peter Bailey
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2022, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.795735

3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma

Auteurs: Xinyuan Liu, Beate Gündel, Xidan Li, Jianping Liu, Anthony Wright, Matthias Löhr, Gustav Arvidsson, Rainer Heuchel
Publié dans: Translational Oncology, Numéro 14, 2021, Page(s) 101107, ISSN 1936-5233
Éditeur: Neoplasia Press
DOI: 10.1016/j.tranon.2021.101107

Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx

Auteurs: Juan J. Montero, Riccardo Trozzo, Maya Sugden, Rupert Öllinger, Alexander Belka, Ekaterina Zhigalova, Paul Waetzig, Thomas Engleitner, Marc Schmidt-Supprian, Dieter Saur, Roland Rad
Publié dans: Nature Methods, Numéro 21, 2024, Page(s) 584-596, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-024-02190-0

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

Auteurs: Bhavana Gupta, Adam C. Errington, Ana Jimenez-Pascual, Vasileios Eftychidis, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz, David Petrik, Florian A. Siebzehnrubl
Publié dans: Cell Reports, Numéro 36, 2022, Page(s) 109588, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.109588

Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic Cancer

Auteurs: Ruthger van Roey, Thomas Brabletz, Marc P. Stemmler, Isabell Armstark
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.753456

Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells

Auteurs: Michele Simbolo, Nicola Silvestris, Giuseppe Malleo, Andrea Mafficini, Laura Maggino, Alessandra Cocomazzi, Lisa Veghini, Aldo Mombello, Francesco Pezzini, Elisabetta Sereni, Filippo M. Martelli, Anastasios Gkountakos, Chiara Ciaparrone, Maria L. Piredda, Giuseppe Ingravallo, Gaetano Paolino, Floriana Nappo, Ilario G. Rapposelli, Luca Frassinetti, Luca Saragoni, Sara Lonardi, Antonio Pea, Salvator
Publié dans: Modern Pathology, Numéro 36, 2024, Page(s) 100251, ISSN 0893-3952
Éditeur: Nature Publishing Group
DOI: 10.1016/j.modpat.2023.100251

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Auteurs: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi
Publié dans: Journal of Experimental & Clinical Cancer Research, Numéro 40, 2022, ISSN 1756-9966
Éditeur: SpingerNature
DOI: 10.1186/s13046-021-02049-8

Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma

Auteurs: Andrea Vallés-Martí, Giulia Mantini, Paul Manoukian, Cynthia Waasdorp, Arantza Fariña Sarasqueta, Richard R. de Goeij-de Haas, Alex A. Henneman, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Elisa Giovannetti, Maarten F. Bijlsma, Connie R. Jiménez
Publié dans: Cell Reports, Numéro 42, 2024, Page(s) 112581, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.112581

LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth

Auteurs: Oihane Erice, Shruthi Narayanan, Iker Feliu, Rodrigo Entrialgo-Cadierno, Antonia Malinova, Caterina Vicentini, Elizabeth Guruceaga, Pietro Delfino, Marija Trajkovic-Arsic, Haritz Moreno, Karmele Valencia, Ester Blanco, Irati Macaya, Daniel Öhlund, Purvesh Khatri, Fernando Lecanda, Aldo Scarpa, Jens T. Siveke, Vincenzo Corbo, Mariano Ponz-Sarvise, Silve Vicent
Publié dans: Clinical Cancer Research, Numéro 29, 2023, Page(s) 1137-1154, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-0794

A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment

Auteurs: Marlene Geyer, Daniel Schreyer, Lisa-Marie Gaul, Susanne Pfeffer, Christian Pilarsky, Karla Queiroz
Publié dans: Cell Death Discovery, Numéro 9, 2023, ISSN 2058-7716
Éditeur: SpringerNature
DOI: 10.1038/s41420-023-01334-z

Refining the Treatment of Pancreatic Cancer From Big Data to Improved Individual Survival

Auteurs: Peter Bailey, Xu Zhou, Jingyu An, Teresa Peccerella, Kai Hu, Christoph Springfeld, Markus Büchler, John P Neoptolemos
Publié dans: Function, Numéro 4, 2023, ISSN 2633-8823
Éditeur: american physiological society
DOI: 10.1093/function/zqad011

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Auteurs: Markus Breunig, Jessica Merkle, Martin Wagner, Michael K. Melzer, Thomas F.E. Barth, Thomas Engleitner, Johannes Krumm, Sandra Wiedenmann, Christian M. Cohrs, Lukas Perkhofer, Gaurav Jain, Jana Krüger, Patrick C. Hermann, Maximilian Schmid, Tamara Madácsy, Árpád Varga, Joscha Griger, Ninel Azoitei, Martin Müller, Oliver Wessely, Pamela G. Robey, Sandra Heller, Zahra Dantes, Maximilian Reicher
Publié dans: Cell Stem Cell, Numéro 28, 2023, Page(s) 1105-1124.e19, ISSN 1934-5909
Éditeur: Cell Press
DOI: 10.1016/j.stem.2021.03.005

Graphene Oxide Nanoparticles and Organoids: A Prospective Advanced Model for Pancreatic Cancer Research

Auteurs: Shaoshan Mai, Iwona Inkielewicz-Stepniak
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2024, Page(s) 1066, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25021066

Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator

Auteurs: Hang He, Shuman Zhang, Hai Yang, Pengyan Xu, Isabella Kutschick, Susanne Pfeffer, Nathalie Britzen-Laurent, Robert Grützmann, Deliang Fu, Christian Pilarsky
Publié dans: Cancers, Numéro 15, 2023, Page(s) 241, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010241

Serum levels of <scp>iCAF</scp>‐derived osteoglycin predict favorable outcome in pancreatic cancer

Auteurs: Mark P. G. Dings, Paul Manoukian, Cynthia Waasdorp, Judith S. E. Quik, Marin Strijker, Sophie C. Lodestijn, Sanne M. van Neerven, Leandro F. Moreno, Rodrigo Leite de Oliveira, Bert A. Bonsing, Marco J. Bruno, Olivier R. Busch, Michael Doukas, Casper H. van Eijck, Nadia Haj Mohammad, Ignace H. de Hingh, Quintus I. Molenaar, Marc G. Besselink, Louis Vermeulen, Jan Paul Medema, Hanneke W. M. van Laar
Publié dans: International Journal of Cancer, Numéro 152, 2023, Page(s) 511-523, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34276

Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening

Auteurs: Marlene Geyer, Karla Queiroz
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.761807

Assessing the Layer-by-Layer Assembly of Cellulose Nanofibrils and Polyelectrolytes in Pancreatic Tumor Spheroid Formation

Auteurs: Negar Abbasi Aval, Ekeram Lahchaichi, Oana Tudoran, Farzaneh Fayazbakhsh, Rainer Heuchel, Matthias Löhr, Torbjörn Pettersson, Aman Russom
Publié dans: Biomedicines, Numéro 11, 2023, Page(s) 3061, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines11113061

CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer

Auteurs: Siyuan Zeng, Bin Lan, Xiaofan Ren, Shuman Zhang, Daniel Schreyer, Markus Eckstein, Hai Yang, Nathalie Britzen-Laurent, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Isabella Kutschick, Susanne Pfeffer, Peter Bailey, Andrew Biankin, Robert Grützmann, Christian Pilarsky
Publié dans: Journal of Experimental & Clinical Cancer Research, Numéro 41, 2023, ISSN 1756-9966
Éditeur: SpringerNature
DOI: 10.1186/s13046-022-02443-w

Analysis pipelines for cancer genome sequencing in mice

Auteurs: Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S. Vassiliou, Mathias J. Friedrich, Dieter Saur, Ignacio Varela, Roland Rad
Publié dans: Nature Protocols, Numéro 15, 2023, Page(s) 266-315, ISSN 1754-2189
Éditeur: Nature Publishing Group
DOI: 10.1038/s41596-019-0234-7

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance

Auteurs: Antonia Malinova, Lisa Veghini, Francisco X. Real, Vincenzo Corbo
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.795251

CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

Auteurs: Bin Lan, Siyuan Zeng, Shuman Zhang, Xiaofan Ren, Yuming Xing, Isabella Kutschick, Susanne Pfeffer, Benjamin Frey, Nathalie Britzen-Laurent, Robert Grützmann, Nils Cordes, Christian Pilarsky
Publié dans: Cancers, Numéro 14, 2024, Page(s) 326, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14020326

Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer

Auteurs: Sushmitha Sankarasubramanian, Ulrike Pfohl, Christian R. A. Regenbrecht, Christoph Reinhard, Lena Wedeken
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.760705

Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells

Auteurs: María Lasierra Losada, Melissa Pauler, Niels Vandamme, Steven Goossens, Geert Berx, Moritz Leppkes, Harald Schuhwerk, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler
Publié dans: Cell Death Discovery, Numéro 7, 2022, ISSN 2058-7716
Éditeur: SpringerNature
DOI: 10.1038/s41420-021-00522-z

The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model

Auteurs: Marlene Geyer, Lisa-Marie Gaul, Sabrina Luigia D`Agosto, Vincenzo Corbo, Karla Queiroz
Publié dans: Frontiers in Immunology, Numéro 14, 2023, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2023.1155085

Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC

Auteurs: Carlotta Cattolico, Peter Bailey, Simon T. Barry
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 10, 2023, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2022.816517

Dynamic EMT: a multi‐tool for tumor progression

Auteurs: Simone Brabletz, Harald Schuhwerk, Thomas Brabletz, Marc P. Stemmler
Publié dans: The EMBO Journal, Numéro 40, 2023, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.2021108647

The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

Auteurs: Harald Schuhwerk, Julia Kleemann, Pooja Gupta, Ruthger van Roey, Isabell Armstark, Martina Kreileder, Nora Feldker, Vignesh Ramesh, Yussuf Hajjaj, Kathrin Fuchs, Mousumi Mahapatro, Mojca Hribersek, Marco Volante, Arwin Groenewoud, Felix B. Engel, Paolo Ceppi, Markus Eckstein, Arndt Hartmann, Fabian Müller, Torsten Kroll, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz
Publié dans: Cell Reports, Numéro 41, 2024, Page(s) 111819, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111819

Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models

Auteurs: Beate Gündel, Xinyuan Liu, Matthias Löhr, Rainer Heuchel
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.741162

Long-term organoid culture of a small intestinal neuroendocrine tumor

Auteurs: Sabrina D’Agosto, Elena Fiorini, Francesco Pezzini, Pietro Delfino, Michele Simbolo, Caterina Vicentini, Silvia Andreani, Paola Capelli, Borislav Rusev, Rita T. Lawlor, Claudio Bassi, Luca Landoni, Antonio Pea, Claudio Luchini, Aldo Scarpa, Vincenzo Corbo
Publié dans: Frontiers in Endocrinology, Numéro 14, 2023, ISSN 1664-2392
Éditeur: Frontiers
DOI: 10.3389/fendo.2023.999792

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