PancREatic Cancer OrganoiDs rEsearch Network

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Catalogue of stromal and cancer cell-specific genes changed by anti-cancer treatment
Procedures and protocols for establishment of organoid cultures from rare histologies

Procedures and protocols for establishment of organoid cultures from rare histologies in conjunction with WP1

List of metastasis associated genes in GEPOs
Report on a modification of the consensus classifier for use on organoids and knowledge on the corresponding tumour cell biology
Report on functional characterisation of selected stromal and cancer cell-specific genes
Report on genome-scale CIRSPR/Cas9 essentiality screening of 25 cancers to discover vulnerabilities and integration of genomic data
Design of the microfluidics for combinatorial dispensing
Publication of at least 15 high quality manuscripts in scientific journals

Report on publication of at least 15 high quality manuscripts in scientific journals

Report on a rational strategy for combinatorial therapy based on PaCa organoid co-cultures
Report on a metabolomics signature for drug screening
Report on the role of single genes in EMT of PaCa

Internet distribution channels operational
PRECODE website set-up and running

PRECODE website setup and running

Report on 2nd series of activities – Hands-on training – ESR project reports

Report on 2nd series of activities Handson training ESR project reports

Report on 1st series of activities - Teambuilding - Hands-on training

Report on 1st series of activities Teambuilding Handson training

Adoption of a exploitation strategy
Adoption of IP policy

Adoption of IP policy as part of the CA

Distribution of news on internet channels

Distribution of news on internet channels News will be continually distributed through the diverse internet channels at least until month 48

Report on 4th series of activities- Entrepreneurship
Report on 3rd series of activities - ESR transferable skills – IPR – midterm review on ESR projects

Report on 3rd series of activities ESR transferable skills IPR midterm review on ESR projects

Report on 6th series of activities - Review of ESRs success in the job market
Report on 5th series of activities - Final review of ESR progress - career fair

Pubblicazioni

Targeting Tumor-Stromal Interactions in Pancreatic Cancer: Impact of Collagens and Mechanical Traits

Autori: Parniyan Maneshi, James Mason, Mitesh Dongre, Daniel Öhlund
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.787485

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer Growth

Autori: Paul Manoukian, Maarten Bijlsma, Hanneke van Laarhoven
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.743907

PDAC as an Immune Evasive Disease: Can 3D Model Systems Aid to Tackle This Clinical Problem?

Autori: Shruthi Narayanan, Silve Vicent, Mariano Ponz-Sarvisé
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.787249

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression

Autori: Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40822-9

Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer

Autori: Hai Yang, Bin Liu, Dongxue Liu, Zhirong Yang, Shuman Zhang, Pengyan Xu, Yuming Xing, Isabella Kutschick, Susanne Pfeffer, Nathalie Britzen-Laurent, Robert Grützmann, Christian Pilarsky
Pubblicato in: Cancers, Numero 14, 2023, Pagina/e 3152, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14133152

Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development

Autori: Shannon R. Nelson, Chenxi Zhang, Sandra Roche, Fiona O’Neill, Niall Swan, Yonglun Luo, AnneMarie Larkin, John Crown, Naomi Walsh
Pubblicato in: Scientific Reports, Numero 10, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-59368-7

Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer

Autori: Shuman Zhang, Duo Yun, Hao Yang, Markus Eckstein, Gihan Daw Elbait, Yaxing Zhou, Yanxi Lu, Hai Yang, Jinping Zhang, Isabella Dörflein, Nathalie Britzen-Laurent, Susanne Pfeffer, Marc P. Stemmler, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Hang He, Siyuan Zeng, Bin Lan, Benjamin Frey, Chuanpit Hampel, Eva Lentsch, Paradesi Naidu Gollavilli, Christian Büttner, Arif B. Ekici, Andrew Biankin
Pubblicato in: Cell Death Discovery, Numero 10, 2024, ISSN 2058-7716
Editore: SpringerNature
DOI: 10.1038/s41420-024-01890-y

Pre-clinical Models of Metastasis in Pancreatic Cancer

Autori: Maria Miquel, Shuman Zhang, Christian Pilarsky
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.748631

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

Autori: Joscha Griger, Sebastian A. Widholz, Moritz Jesinghaus, Niklas de Andrade Krätzig, Sebastian Lange, Thomas Engleitner, Juan José Montero, Ekaterina Zhigalova, Rupert Öllinger, Veveeyan Suresh, Wiebke Winkler, Svenja Lier, Olga Baranov, Riccardo Trozzo, Najib Ben Khaled, Shounak Chakraborty, Jiakun Yu, Björn Konukiewitz, Katja Steiger, Nicole Pfarr, Ashish Rajput, David Sailer, Gisela Keller, P
Pubblicato in: Cancer Cell, Numero 41, 2024, Pagina/e 1327-1344.e10, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2023.06.001

Editorial: Translational Insights Into Pancreatic Ductal Adenocarcinoma

Autori: Maarten F. Bijlsma, Peter J. Bailey, Marc P. Stemmler
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 10, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.875836

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

Autori: Mónica P de Andrés, Richard J Jackson, Irene Felipe, Sladjana Zagorac, Christian Pilarsky, Anna Melissa Schlitter, Jaime Martinez de Villareal, Gun Ho Jang, Eithne Costello, Steve Gallinger, Paula Ghaneh, William Greenhalf, Thomas Knösel, Daniel H Palmer, Petra Ruemmele, Wilko Weichert, Markus Buechler, Thilo Hackert, John P Neoptolemos, Faiyaz Notta, Núria Malats, Paola Martinelli, Francisco
Pubblicato in: Gut, Numero 72, 2023, Pagina/e 535-548, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325803

Loss of FGFR4 promotes the malignant phenotype of PDAC

Autori: Sabrina D’Agosto, Francesco Pezzini, Lisa Veghini, Pietro Delfino, Claudia Fiorini, Gael D. Temgue Tane, Anais Del Curatolo, Caterina Vicentini, Giorgia Ferrari, Davide Pasini, Silvia Andreani, Francesca Lupo, Elena Fiorini, Giulia Lorenzon, Rita T. Lawlor, Borislav Rusev, Antonia Malinova, Claudio Luchini, Michele Milella, Elisabetta Sereni, Antonio Pea, Claudio Bassi, Peter Bailey, Aldo Scarpa
Pubblicato in: Oncogene, Numero 41, 2022, Pagina/e 4371-4384, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-022-02432-5

Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

Autori: Francesca Lupo, Francesco Pezzini, Davide Pasini, Elena Fiorini, Annalisa Adamo, Lisa Veghini, Michele Bevere, Cristina Frusteri, Pietro Delfino, Sabrina D'agosto, Silvia Andreani, Geny Piro, Antonia Malinova, Tian Wang, Francesco De Sanctis, Rita Teresa Lawlor, Chang-il Hwang, Carmine Carbone, Ivano Amelio, Peter Bailey, Vincenzo Bronte, David Tuveson, Aldo Scarpa, Stefano Ugel, Vincenzo Corbo
Pubblicato in: Gut, Numero 73, 2024, Pagina/e 1321-1335, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-329807

Microfluidics and Organoids, the Power Couple of Developmental Biology and Oncology Studies

Autori: Laura Ann Hetzel, Ahmed Ali, Vincenzo Corbo, Thomas Hankemeier
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 10882, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241310882

Deconstructing Pancreatic Cancer Using Next Generation-Omic Technologies–From Discovery to Knowledge-Guided Platforms for Better Patient Management

Autori: Daniel Schreyer, John P. Neoptolemos, Simon T. Barry, Peter Bailey
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.795735

3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma

Autori: Xinyuan Liu, Beate Gündel, Xidan Li, Jianping Liu, Anthony Wright, Matthias Löhr, Gustav Arvidsson, Rainer Heuchel
Pubblicato in: Translational Oncology, Numero 14, 2021, Pagina/e 101107, ISSN 1936-5233
Editore: Neoplasia Press
DOI: 10.1016/j.tranon.2021.101107

Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx

Autori: Juan J. Montero, Riccardo Trozzo, Maya Sugden, Rupert Öllinger, Alexander Belka, Ekaterina Zhigalova, Paul Waetzig, Thomas Engleitner, Marc Schmidt-Supprian, Dieter Saur, Roland Rad
Pubblicato in: Nature Methods, Numero 21, 2024, Pagina/e 584-596, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-024-02190-0

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

Autori: Bhavana Gupta, Adam C. Errington, Ana Jimenez-Pascual, Vasileios Eftychidis, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz, David Petrik, Florian A. Siebzehnrubl
Pubblicato in: Cell Reports, Numero 36, 2022, Pagina/e 109588, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109588

Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic Cancer

Autori: Ruthger van Roey, Thomas Brabletz, Marc P. Stemmler, Isabell Armstark
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.753456

Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells

Autori: Michele Simbolo, Nicola Silvestris, Giuseppe Malleo, Andrea Mafficini, Laura Maggino, Alessandra Cocomazzi, Lisa Veghini, Aldo Mombello, Francesco Pezzini, Elisabetta Sereni, Filippo M. Martelli, Anastasios Gkountakos, Chiara Ciaparrone, Maria L. Piredda, Giuseppe Ingravallo, Gaetano Paolino, Floriana Nappo, Ilario G. Rapposelli, Luca Frassinetti, Luca Saragoni, Sara Lonardi, Antonio Pea, Salvator
Pubblicato in: Modern Pathology, Numero 36, 2024, Pagina/e 100251, ISSN 0893-3952
Editore: Nature Publishing Group
DOI: 10.1016/j.modpat.2023.100251

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Autori: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 40, 2022, ISSN 1756-9966
Editore: SpingerNature
DOI: 10.1186/s13046-021-02049-8

Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma

Autori: Andrea Vallés-Martí, Giulia Mantini, Paul Manoukian, Cynthia Waasdorp, Arantza Fariña Sarasqueta, Richard R. de Goeij-de Haas, Alex A. Henneman, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Elisa Giovannetti, Maarten F. Bijlsma, Connie R. Jiménez
Pubblicato in: Cell Reports, Numero 42, 2024, Pagina/e 112581, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112581

LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth

Autori: Oihane Erice, Shruthi Narayanan, Iker Feliu, Rodrigo Entrialgo-Cadierno, Antonia Malinova, Caterina Vicentini, Elizabeth Guruceaga, Pietro Delfino, Marija Trajkovic-Arsic, Haritz Moreno, Karmele Valencia, Ester Blanco, Irati Macaya, Daniel Öhlund, Purvesh Khatri, Fernando Lecanda, Aldo Scarpa, Jens T. Siveke, Vincenzo Corbo, Mariano Ponz-Sarvise, Silve Vicent
Pubblicato in: Clinical Cancer Research, Numero 29, 2023, Pagina/e 1137-1154, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-0794

A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment

Autori: Marlene Geyer, Daniel Schreyer, Lisa-Marie Gaul, Susanne Pfeffer, Christian Pilarsky, Karla Queiroz
Pubblicato in: Cell Death Discovery, Numero 9, 2023, ISSN 2058-7716
Editore: SpringerNature
DOI: 10.1038/s41420-023-01334-z

Refining the Treatment of Pancreatic Cancer From Big Data to Improved Individual Survival

Autori: Peter Bailey, Xu Zhou, Jingyu An, Teresa Peccerella, Kai Hu, Christoph Springfeld, Markus Büchler, John P Neoptolemos
Pubblicato in: Function, Numero 4, 2023, ISSN 2633-8823
Editore: american physiological society
DOI: 10.1093/function/zqad011

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Autori: Markus Breunig, Jessica Merkle, Martin Wagner, Michael K. Melzer, Thomas F.E. Barth, Thomas Engleitner, Johannes Krumm, Sandra Wiedenmann, Christian M. Cohrs, Lukas Perkhofer, Gaurav Jain, Jana Krüger, Patrick C. Hermann, Maximilian Schmid, Tamara Madácsy, Árpád Varga, Joscha Griger, Ninel Azoitei, Martin Müller, Oliver Wessely, Pamela G. Robey, Sandra Heller, Zahra Dantes, Maximilian Reicher
Pubblicato in: Cell Stem Cell, Numero 28, 2023, Pagina/e 1105-1124.e19, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2021.03.005

Graphene Oxide Nanoparticles and Organoids: A Prospective Advanced Model for Pancreatic Cancer Research

Autori: Shaoshan Mai, Iwona Inkielewicz-Stepniak
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, Pagina/e 1066, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25021066

Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator

Autori: Hang He, Shuman Zhang, Hai Yang, Pengyan Xu, Isabella Kutschick, Susanne Pfeffer, Nathalie Britzen-Laurent, Robert Grützmann, Deliang Fu, Christian Pilarsky
Pubblicato in: Cancers, Numero 15, 2023, Pagina/e 241, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010241

Serum levels of <scp>iCAF</scp>‐derived osteoglycin predict favorable outcome in pancreatic cancer

Autori: Mark P. G. Dings, Paul Manoukian, Cynthia Waasdorp, Judith S. E. Quik, Marin Strijker, Sophie C. Lodestijn, Sanne M. van Neerven, Leandro F. Moreno, Rodrigo Leite de Oliveira, Bert A. Bonsing, Marco J. Bruno, Olivier R. Busch, Michael Doukas, Casper H. van Eijck, Nadia Haj Mohammad, Ignace H. de Hingh, Quintus I. Molenaar, Marc G. Besselink, Louis Vermeulen, Jan Paul Medema, Hanneke W. M. van Laar
Pubblicato in: International Journal of Cancer, Numero 152, 2023, Pagina/e 511-523, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34276

Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening

Autori: Marlene Geyer, Karla Queiroz
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.761807

Assessing the Layer-by-Layer Assembly of Cellulose Nanofibrils and Polyelectrolytes in Pancreatic Tumor Spheroid Formation

Autori: Negar Abbasi Aval, Ekeram Lahchaichi, Oana Tudoran, Farzaneh Fayazbakhsh, Rainer Heuchel, Matthias Löhr, Torbjörn Pettersson, Aman Russom
Pubblicato in: Biomedicines, Numero 11, 2023, Pagina/e 3061, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines11113061

CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer

Autori: Siyuan Zeng, Bin Lan, Xiaofan Ren, Shuman Zhang, Daniel Schreyer, Markus Eckstein, Hai Yang, Nathalie Britzen-Laurent, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Isabella Kutschick, Susanne Pfeffer, Peter Bailey, Andrew Biankin, Robert Grützmann, Christian Pilarsky
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 41, 2023, ISSN 1756-9966
Editore: SpringerNature
DOI: 10.1186/s13046-022-02443-w

Analysis pipelines for cancer genome sequencing in mice

Autori: Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S. Vassiliou, Mathias J. Friedrich, Dieter Saur, Ignacio Varela, Roland Rad
Pubblicato in: Nature Protocols, Numero 15, 2023, Pagina/e 266-315, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-019-0234-7

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance

Autori: Antonia Malinova, Lisa Veghini, Francisco X. Real, Vincenzo Corbo
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.795251

CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

Autori: Bin Lan, Siyuan Zeng, Shuman Zhang, Xiaofan Ren, Yuming Xing, Isabella Kutschick, Susanne Pfeffer, Benjamin Frey, Nathalie Britzen-Laurent, Robert Grützmann, Nils Cordes, Christian Pilarsky
Pubblicato in: Cancers, Numero 14, 2024, Pagina/e 326, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14020326

Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer

Autori: Sushmitha Sankarasubramanian, Ulrike Pfohl, Christian R. A. Regenbrecht, Christoph Reinhard, Lena Wedeken
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.760705

Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells

Autori: María Lasierra Losada, Melissa Pauler, Niels Vandamme, Steven Goossens, Geert Berx, Moritz Leppkes, Harald Schuhwerk, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler
Pubblicato in: Cell Death Discovery, Numero 7, 2022, ISSN 2058-7716
Editore: SpringerNature
DOI: 10.1038/s41420-021-00522-z

The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model

Autori: Marlene Geyer, Lisa-Marie Gaul, Sabrina Luigia D`Agosto, Vincenzo Corbo, Karla Queiroz
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2023.1155085

Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC

Autori: Carlotta Cattolico, Peter Bailey, Simon T. Barry
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 10, 2023, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.816517

Dynamic EMT: a multi‐tool for tumor progression

Autori: Simone Brabletz, Harald Schuhwerk, Thomas Brabletz, Marc P. Stemmler
Pubblicato in: The EMBO Journal, Numero 40, 2023, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2021108647

The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

Autori: Harald Schuhwerk, Julia Kleemann, Pooja Gupta, Ruthger van Roey, Isabell Armstark, Martina Kreileder, Nora Feldker, Vignesh Ramesh, Yussuf Hajjaj, Kathrin Fuchs, Mousumi Mahapatro, Mojca Hribersek, Marco Volante, Arwin Groenewoud, Felix B. Engel, Paolo Ceppi, Markus Eckstein, Arndt Hartmann, Fabian Müller, Torsten Kroll, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz
Pubblicato in: Cell Reports, Numero 41, 2024, Pagina/e 111819, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111819

Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models

Autori: Beate Gündel, Xinyuan Liu, Matthias Löhr, Rainer Heuchel
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.741162

Long-term organoid culture of a small intestinal neuroendocrine tumor

Autori: Sabrina D’Agosto, Elena Fiorini, Francesco Pezzini, Pietro Delfino, Michele Simbolo, Caterina Vicentini, Silvia Andreani, Paola Capelli, Borislav Rusev, Rita T. Lawlor, Claudio Bassi, Luca Landoni, Antonio Pea, Claudio Luchini, Aldo Scarpa, Vincenzo Corbo
Pubblicato in: Frontiers in Endocrinology, Numero 14, 2023, ISSN 1664-2392
Editore: Frontiers
DOI: 10.3389/fendo.2023.999792

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