Pathogen Oriented SNARE Trafficking for Immune Tailoring

Project Information

POST-IT

Grant agreement ID: 862137

DOI

10.3030/862137

Project closed

EC signature date 30 January 2020

Start date 1 May 2020

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Participation in the Open Research Data Pilot

Publications

Peer reviewed articles (27)

The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19

Author(s): Maksim V. Baranov, Frans Bianchi, Geert van den Bogaart
Published in: Cells, Issue 10/1, 2021, Page(s) 30, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010030

Rerouting trafficking circuits through posttranslational SNARE modifications

Author(s): Warner, H.M., Mahajan, S., & van den Bogaart, G.
Published in: Journal of Cell Science, Issue 35, 2022, Page(s) jcs260112, ISSN 1477-9137
Publisher: Company of Biologists
DOI: 10.1242/jcs.260112

CD36 as a double-edged sword in cancer

Author(s): Muwei Jiang, Renske Karsenberg, Frans Bianchi, Geert van den Bogaart
Published in: Immunology Letters, Issue 265, 2024, Page(s) 7-15, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2023.12.002

5-Ethynyluridine: a bio-orthogonal uridine variant for mRNA-based therapies and vaccines.

Author(s): Maassen, S., Coenen, B., Dulk, S., van der Werff, M., Warner, H., Spada, F., Frischmuth, T., Incarnato, D., & van den Bogaart, G.
Published in: ChemBioChem, Issue 24, 2023, Page(s) e202200658, ISSN 1439-7633
Publisher: John Wiley
DOI: 10.1002/cbic.202200658

Unveiling the impact of <scp>GOLM1</scp>/<scp>GP73</scp> on cytokine production in cancer and infectious disease

Author(s): Myrthe T Frans, Ella M Kuipers, Frans Bianchi, Geert van den Bogaart
Published in: Immunology &amp; Cell Biology, Issue 101, 2023, Page(s) 727-734, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12664

A quantitative in vitro collagen uptake assay

Author(s): Sjors Maassen, Harry M. Warner, Pieter Grijpstra, Geert van den Bogaart
Published in: MethodsX, Issue 11, 2023, Page(s) 102288, ISSN 2215-0161
Publisher: Elsevier
DOI: 10.1016/j.mex.2023.102288

Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration Through the Extracellular Matrix

Author(s): Harry Marcus Warner, Giulia Franciosa, Guus van der Borg, Felix Faas, Claire Koenig, Rinse de Boer, Rene Classens, Sjors Maassen, Maksim Baranov, Shweta Mahajan, Deepti Dabral, Britt Coenen, Frans Bianchi, Niek van Hilten, Herre Jelger Risselada, Wouter Roos, Jesper Velgaard Olsen, Laia Querol Cano, Geert van den Bogaart
Published in: Cell Reports, Issue 43, 2023, Page(s) 113866., ISSN 2211-1247
Publisher: Cell Press
DOI: 10.2139/ssrn.4332064

Vacuolar escape of foodborne bacterial pathogens

Author(s): Frans Bianchi, Geert van den Bogaart
Published in: Journal of Cell Science, Issue 134/5, 2020, Page(s) jcs247221, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.247221

Fluorescence lifetime imaging of pH along the secretory pathway

Author(s): Linders P; ter Beest M; van den Bogaart G; van den Bogaart G
Published in: ACS chemical biology, Issue 15548929, 2022, Page(s) 240-251, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00907

Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters

Author(s): Femmy C. Stempels, Muwei Jiang, Harry M. Warner, Magda-Lena Moser, Maaike H. Janssens, Sjors Maassen, Iris H. Nelen, Rinse de Boer, William F. Jiemy, David Knight, Julian Selley, Ronan O’Cualain, Maksim V. Baranov, Thomas C.Q. Burgers, Roberto Sansevrino, Dragomir Milovanovic, Peter Heeringa, Matthew C. Jones, Rifka Vlijm, Martin ter Beest, Geert van den Bogaart
Published in: Journal of Cell Biology, Issue 222, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205130

The Roles of Phospholipase A2 in Phagocytes

Author(s): Dabral, D., van den Bogaart, G
Published in: Front. Cell Dev. Biol., Issue 2296634X, 2021, Page(s) 673502, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.673502

Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages.

Author(s): Maassen, S., Warner, H., Ioannidis, M., Jansma, J., Markus, H., El Aidy, S., Chiara, M., Luis Chiara, J., Maierhofer, L., Weavers, H. & van den Bogaart, G.
Published in: Free Radic. Biol. Med., Issue 18734596, 2022, Page(s) 287-297, ISSN 1873-4596
Publisher: Elsevier
DOI: 10.1016/j.freeradbiomed.2022.06.235

Reverse Signaling by MHC-I Molecules in Immune and Non-Immune Cell Types

Author(s): Elke M. Muntjewerff, Luca D. Meesters, Geert van den Bogaart, Natalia H. Revelo
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.605958

Congenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5

Author(s): Peter T. A. Linders, Eveline C. F. Gerretsen, Angel Ashikov, Mari-Anne Vals, Rinse de Boer, Natalia H. Revelo, Richard Arts, Melissa Baerenfaenger, Fokje Zijlstra, Karin Huijben, Kimiyo Raymond, Kai Muru, Olga Fjodorova, Sander Pajusalu, Katrin Õunap, Martin ter Beest, Dirk Lefeber, Geert van den Bogaart
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26534-y

Antigen presentation of post‐translationally modified peptides in major histocompatibility complexes

Author(s): Alexine S de Wit, Frans Bianchi, Geert van den Bogaart
Published in: Immunology &amp; Cell Biology, Issue 103, 2025, Page(s) 161-177, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12839

What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology

Author(s): Dania Altulea, Sjors Maassen, Maksim V Baranov, G van den Bogaart
Published in: Journal of Molecular Cell Biology, Issue 13/3, 2021, Page(s) 175-184, ISSN 1759-4685
Publisher: Oxford Academic
DOI: 10.1093/jmcb/mjab016

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

Author(s): Muwei Jiang, Frans Bianchi, Geert van den Bogaart
Published in: FEBS Letters, 2025, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.70064

A sensitive and less cytotoxic assay for identification of proliferating T cells based on bioorthogonally-functionalized uridine analogue.

Author(s): Stempels, F.C., de Wit, A.S., Swierstra, M.S., Maassen, S., Bianchi, F., van den Bogaart, G., & Baranov, M.V.
Published in: J. Immunol. Methods., Issue 00221759, 2022, Page(s) 113228, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2022.113228

Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages

Author(s): Maassen, S., Coenen, B., Ioannidis, M., Harber, K., Grijpstra, P., Van den Bossche, J., & van den Bogaart, G.
Published in: Redox Biol, Issue 59, 2023, Page(s) 102591, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2022.102591

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

Author(s): Elke M. Muntjewerff, Kechun Tang, Lisanne Lutter, Gustaf Christoffersson, Mara J. T. Nicolasen, Hong Gao, Gajanan D. Katkar, Soumita Das, Martin ter Beest, Wei Ying, Pradipta Ghosh, Sahar El Aidy, Bas Oldenburg, Geert van den Bogaart, Sushil K. Mahata
Published in: Acta Physiologica, Issue 232/2, 2021, ISSN 1748-1708
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apha.13655

Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class II epitopes. 12: .

Author(s): Bilderbeek, R., Baranov, M., van den Bogaart., G., & Bianchi, F.
Published in: Front. Immunol., Issue 16643224, 2022, Page(s) 763044, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.763044

Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin)

Author(s): Wei Ying, Kechun Tang, Ennio Avolio, Jan M. Schilling, Teresa Pasqua, Matthew A. Liu, Hongqiang Cheng, Hong Gao, Jing Zhang, Sumana Mahata, Myung S. Ko, Gautam Bandyopadhyay, Soumita Das, David M. Roth, Debashis Sahoo, Nicholas J.G. Webster, Farah Sheikh, Gourisankar Ghosh, Hemal H. Patel, Pradipta Ghosh, Geert van den Bogaart, Sushil K. Mahata
Published in: Hypertension, Issue 77/5, 2021, Page(s) 1670-1682, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.16809

Close membrane apposition facilitates ion gradients in the lumen of phagosomes

Author(s): Baranov, M.V., Ioannidis, M., Balahsioui, S., Boersma, A., de Boer R., Kumar, M., Niwa, M., Hirayama, T., Zhou, Q., Hopkins, T.M., Grijpstra, P., Thutupalli, S., Sacanna, S., & van den Bogaart G.
Published in: Biophys. Rep., Issue 26670747, 2022, Page(s) 100069, ISSN 2667-0747
Publisher: Elsevier
DOI: 10.1016/j.bpr.2022.100069

Antigen Cross-Presentation by Macrophages

Author(s): Elke M. Muntjewerff, Luca D. Meesters, Geert van den Bogaart
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.01276

Novel and conventional inhibitors of canonical autophagy differently affect LC3-associated phagocytosis

Author(s): Femmy C. Stempels; Maaike H. Janssens; Martin Beest; Rob J. Mesman; Natalia H. Revelo; Melina Ioannidis; Geert den Bogaart
Published in: urn:issn:, Issue 00145793, 2022, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.5281/zenodo.5714529

Sugary Logistics Gone Wrong: Membrane Trafficking and Congenital Disorders of Glycosylation

Author(s): Peter T. A. Linders, Ella Peters, Martin ter Beest, Dirk J. Lefeber, Geert van den Bogaart
Published in: International Journal of Molecular Sciences, Issue 21/13, 2020, Page(s) 4654, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21134654

Modulation of Immune Responses by Particle Size and Shape

Author(s): Maksim V. Baranov, Manoj Kumar, Stefano Sacanna, Shashi Thutupalli, Geert van den Bogaart
Published in: Frontiers in Immunology, Issue 11, 2021, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.607945