The activities conducted in the third reporting period were mainly focused on the implementation of improvements on the e-infrastructure, including a new dashboard, as well as new functionalities related with the toxicological profiling engine, and the NanoExposure Quantifier (NEQ) model implementation. In parallel, a validation program was implemented to test and demonstrate the applicability of the e-infrastructure to select proper measures to develop safer materials and processes. Finally, concerning dissemination and communication activities, the outcomes and findings of the project were presented during the Anthos´24 “Advanced (Nano)Materials and Technologies: Science, Research & Innovation for Safety and Sustainability” event, organized by the Bionanonet (BNN) last March 2024 in Vienna (Austria), where leading experts in Safe-by-Design (SbD) and Safe-and-Sustainable-by-Design (SSbD) were present
A summary of the main results achieved is provided below:
1) An updated web based community knowledge infrastructure / WP1
2) New refined hypothesis for physical-chemical properties and functionality relationships. An open server website for toxicity prediction of ENMs was delivered, being implemented in such a way that can be directly used by the e-infrastructure developed in WP5 / WP2
3) A new set of strategies to reduce toxicity based on the use of molecules with biological origen for surface modifications / WP3
4) A fit-for-purpose exposure model (Nano Exposure Quantifier model (NEQ)) integrating algorithms to estimate the exposure and RMM values. New data on the efficiency of engineering controls based on Computational fluid dynamics (CFD) / WP4
5) A new version (1.0) of the e-infrastructure, inlcuding a new SbD case dashboard designed to provide quick insight in the entire case, as well as access to updated versions of a subset of SdD resources / WP5
6) Case study reports including detailed information on the applicability of the approaches developed. Excel based tool to support a harmonized cost analysis / WP6
7) A new guideline on SbD integration in the risk governance framework / WP7
Concerning key exploitable results, the reserch organizations developed the exploitable solutions that can be used to provide added value services: Toxicological profiling interface,Literature searching engine,QSAR Models,NanoExposure Quantifier / ECEL library, Exposure/release coefficients, CFD algorithms, Software code, software interface, and the so-called Influence Diagrams. In addition, it should be noted that the e-infrastructure is one of the KERs of the project. For its part, the compaines developed a new line of products, including: Safe by design Carbon Nanofibers,Safe by design Graphene and Graphene composites, Safe by design Fluorescent silica nanobeads, Safe by design – Eye drops and food/cosmetic product development, Safe by design carbon based NMs for their use in thermosetting and thermoplastic nanocomposites, Safe by design of fluorescent silica nanoparticles, Safe by design production of TiO2-SiO2 NPs, Safe by design production of nano TiO2 and ZnO, Safe by design SiO2,TiO2 ENMs based coatings and SiO2 based nanocapsules.
